Recanalization of Chronic Occlusion of the Middle Cerebral Artery With Tissue Plasminogen Activator Treatment: A Case Report.

Objectives: Patients with chronic proximal middle cerebral artery (MCA) occlusion do not present with severe symptoms, but early recanalization of acute occlusion is associated with high morbidity and mortality. Tissue plasminogen activator (tPA) is a recombinant thrombolytic agent approved for treating ischemic stroke, although only a few cases of tPA administration in chronic MCA occlusion have yielded positive results.

Methods: A 71-year-old patient had a history of right MCA territorial infarction with the occlusion occurring 12 years ago (November 2005).

Thrombocytopenia induced by dabigatran: two case reports.

Background: Vitamin K inhibitors (e.g. warfarin) and indirect thrombin inhibitors (e.

Structural Analyses of Zinc Finger Domains for Specific Interactions with DNA.

Zinc finger proteins are among the most extensively applied metalloproteins in the field of biotechnology owing to their unique structural and functional aspects as transcriptional and translational regulators. The classical zinc fingers are the largest family of zinc proteins and they provide critical roles in physiological systems from prokaryotes to eukaryotes. Two cysteine and two histidine residues (Cys₂His₂) coordinate to the zinc ion for the structural functions to generate a ββα fold, and this secondary structure supports specific interactions with their binding partners, including DNA, RNA, lipids, proteins, and small molecules.

Status of treatment for dementia patients who visited hospital as the first visit.

We are approaching a period of population ageing in which the number of dementia patients will increase rapidly and become a significant social problem. There are many study guides for treatment of dementia, but there are limited numbers of studies and limited amounts of data available for evaluating the treatment used on dementia patients as related to their hospital for the first time. A study was performed using information gathered from 50 domestic hospitals to ensure that the treatment status data was representative of the actual field of clinical dementia.

Sensory pathways in the human embryonic spinal accessory nerve with special reference to the associated lower cranial nerve ganglia.

Background And Purpose: Muscles supplied by the spinal accessory nerve are particularly prone to the development of trigger points characteristic of myofascial pain. This study aimed to confirm sensory pathways in the spinal accessory nerve and to describe sensory ganglion cell distributions along the lower cranial nerve roots.

Methods: Using sagittal sections of ten human embryos at 6-7 weeks and horizontal sections of three 15- to 16-week-old embryos, we analyzed ganglion cell distributions along the lower cranial nerve roots, including the spinal accessory (XI) nerve.

Site-specific distribution of CD68-positive microglial cells in the brains of human midterm fetuses: a topographical relationship with growing axons.

Using 5 fetuses of gestational age (GA) of 15-16 weeks and 4 of GA of 22-25 weeks, we examined site- and stage-dependent differences in CD68-positive microglial cell distribution in human fetal brains. CD68 positive cells were evident in the floor of the fourth ventricle and the pons and olive at 15-16 weeks, accumulating in and around the hippocampus at 22-25 weeks. At both stages, the accumulation of these cells was evident around the optic tract and the anterior limb of the internal capsule.

Tooth loss may predict poor cognitive function in community-dwelling adults without dementia or stroke: the PRESENT project.

Periodontal disease is a potential predictor of stroke and cognitive impairment. However, this association is unclear in adults aged 50 yr and above without a history of stroke or dementia. We evaluated the association between the number of teeth lost, indicating periodontal disease, and cognitive impairment in community-dwelling adults without any history of dementia or stroke.

Serum YKL-40 levels correlate with infarct volume, stroke severity, and functional outcome in acute ischemic stroke patients.

Background And Purpose: YKL-40 is associated with various neurological disorders. However, circulatory YKL-40 levels early after onset of acute ischemic stroke (AIS) have not been systematically assessed. We aimed to identify the temporal changes and clinical usefulness of measuring serum YKL-40 immediately following AIS.

The anatomy of fetal peripheral lymphatic vessels in the head-and-neck region: an immunohistochemical study.

Using D2-40 immunohistochemistry, we assessed the distribution of peripheral lymphatic vessels (LVs) in the head-and-neck region of four midterm fetuses without nuchal edema, two of 10 weeks and two of 15 weeks' gestation. We observed abundant LVs in the subcutaneous layer, especially in and along the facial muscles. In the occipital region, only a few LVs were identified perforating the back muscles.