Publications by authors named "Jin Sol Baek"
Hepatic stellate cells (HSCs) play a role in hepatic fibrosis and sphingosine kinase (SphK) is involved in biological processes. As studies on the regulatory mechanisms and functions of SphK in HSCs during liver fibrosis are currently limited, this study aimed to elucidate the regulatory mechanism and connected pathways of SphK upon HSC activation. The expression of SphK1 was higher in HSCs than in hepatocytes, and upregulated in activated primary HSCs.
View Article and Find Full Text PDFUltraviolet B (UVB) rays disrupt the skin by causing photodamage via processes such as reactive oxygen species (ROS) production, endoplasmic reticulum (ER) stress, DNA damage, and/or collagen degradation. is an evergreen tree native to the southern Korean peninsula. Although it is known to have antioxidant and anti-inflammatory effects, its protective effect against photodamage in keratinocytes has not been investigated.
View Article and Find Full Text PDFFerroptosis contribute to hepatic stellate cell activation and liver fibrogenesis.
Free Radic Biol Med
November 2022
Article Synopsis
- * Treatment with ferroptosis inducers like RSL3 or erastin led to cell death in HSCs, while ferroptosis inhibitors were able to suppress this effect, indicating a crucial role for ferroptosis in HSC activation.
- * In mouse models, iron accumulation induced ferroptosis and increased markers of fibrosis in the liver, aligning with findings in cirrhotic patient tissue, thereby suggesting ferroptosis is integral to both HSC activation and the progression of liver fibrosis.