Publications by authors named "Jin Shi"

This study presents a novel electrochemical immunosensor for the detection of pepsinogen I, a potential biomarker for gastric cancer, based on a PdAgPt/MoS2 nanocomposite. The nanocomposite was synthesized and characterized, demonstrating enhanced electron transfer properties and a large electroactive surface area. The optimized immunosensor exhibited a wide linear range of 0.

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Liver hepatocellular carcinoma (LIHC) is a major contributor to cancer-related mortality worldwide, posing substantial diagnostic and therapeutic challenges. Although zinc finger proteins (ZNFs) are known to play a role in LIHC, the specific function of ZNF248 remains poorly understood. In this study, we analyzed genomic and clinical data from The Cancer Genome Atlas (TCGA) to elucidate the role of ZNF248 through differential expression analysis, bioenrichment, immune response correlation, and drug sensitivity evaluation.

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  • Accurate detection of driver gene mutations is key for treating lung cancer, but traditional methods require high-quality tissue samples and can be too slow or unavailable for many patients, especially in low-resource areas.
  • The study developed an AI model called DeepGEM, which uses routine histological slides to predict gene mutations without needing prior annotation or high-quality samples.
  • The model was trained and tested on a large dataset of lung cancer patients across multiple hospitals in China, showing promising results in predicting gene mutations, which was further validated on external and public datasets.
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Gastric cancer is one of the most common malignant tumours, with limited treatment options and poor prognosis in its advanced stages. In recent years, breakthroughs in tumour immunotherapy have led to immune checkpoint inhibitors becoming a new class of clinical oncology drugs. Programmed death receptor-1 (PD-1) and programmed death-ligand 1 (PD-L1) play significant roles in inhibiting T cell responses and tumour immune escape.

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Objective: The purpose of this study was to analyze the effectiveness of the Cancer Screening Program in Urban China (CanSPUC) in Hebei Province, 2016-2023.

Methods: A questionnaire for risk factors of lung, breast, upper gastrointestinal, liver, and colorectal cancers was administered to urban residents aged 40-74 years in five cities to assess their cancer risk. High-risk participants were invited for screening and classified into five groups on the basis of the number of cancer types that were assessed to be high risk.

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Type V-F CRISPR-Cas12f is a group of hypercompact RNA-guided nucleases that present a versatile in vivo delivery platform for gene therapy. Upon target recognition, Acidibacillus sulfuroxidans Cas12f (AsCas12f1) distinctively engenders three DNA break sites, two of which are located outside the protospacer. Combining ensemble and single-molecule approaches, we elucidate the molecular details underlying AsCas12f1-mediated DNA cleavages.

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  • The study focuses on the effectiveness and safety of a triple-targeted therapy (dabrafenib, trametinib, and osimertinib) for advanced non-small cell lung cancer (NSCLC) patients who developed a V600E mutation after initially responding to EGFR-TKI treatment.
  • A multi-center review of 13 NSCLC patients showed promising results, with an objective response rate of 61.5% and a disease control rate of 92.3%, alongside a median progression-free survival of 13.5 months.
  • The research also included patient-derived organoids to assess drug response and next-generation sequencing to identify resistance mechanisms, highlighting significant tumor growth inhibition with the triple-targeted therapy compared to other reg
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Metabolic dysfunction-associated fatty liver disease (MAFLD), formerly known as nonalcoholic fatty liver disease (NAFLD), is a common, highly heterogeneous condition that affects about a quarter of the world's population, with no approved drug therapy. Current evidence from preclinical research and a number of small clinical trials indicates that SGLT2 inhibitors could also be effective for MAFLD. MAFLD is associated with a higher risk of chronic liver disease and multiple extrahepatic events, especially cardiovascular disease (CVD) and chronic kidney disease (CKD).

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Tuberculosis, caused by Mycobacterium tuberculosis (Mtb), is a critical global health issue that is complicated by the ability of the pathogen to delay the host's T-cell immune response. This delay in T-cell recruitment to the site of infection is a pivotal survival strategy for Mtb, allowing it to establish a persistent chronic infection. To investigate the underlying mechanisms, this study focused on Mtb's exploitation of host tryptophan metabolism.

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  • The study evaluates the effectiveness of enterovirus A71 (EV-A71) vaccines in reducing hand, foot, and mouth disease (HFMD) cases among children under 5 in China, with analysis based on surveillance data and statistical models.
  • Findings show that between 2017 and 2018, vaccination led to a significant reduction in HFMD incidence, with a relative risk of 0.83, translating to about 298,000 fewer cases.
  • The effectiveness of the vaccine varied by region, was better in areas with higher vaccination coverage (above 20%), and decreased in more densely populated areas, highlighting the need for improved vaccination strategies.
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Background: β-1,3-Galactosyltransferase-4 (B3GALT4), a member of the β-1,3-galactosyltransferase gene family, is essential to the development of many malignancies. However, its biological function in breast cancer is still unknown.

Method: Publically accessible datasets, as well as quantitative real-time PCR, western blot, and immunohistochemistry on our patient cohort were used to investigate the expression levels of B3GALT4 in breast cancer.

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We report here the orchestration of molecular ion networking (MoIN) and a set of computationally assisted structural elucidation approaches in the discovery and assignment of a new class of rearranged 4,5--abietane diterpenoids including serra A (), which possesses an unusual 6/6/5/5 fused-ring skeleton system, together with two previously unreported diterpenoids serras B-C (-) and five known compounds were isolated from (). The structures were elucidated by spectroscopic analysis in conjunction with computationally assisted structure elucidation tools. , serras A-C (-) bind well to PXR, suggesting their potential role in reducing inflammation.

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The utilization of Pickering emulsions in interfacial catalysis offers a promising environmental platform for biphasic reactions. However, complicated surface coating or chemical grafting methods are always required to prepare the surface-active catalysts for the Pickering emulsions, since most of them are commercially unavailable. Here, we report CO-switchable Pickering emulsions for biphasic reactions, in which Pd@AlO nanoparticles are in situ modified by a CO/N responsive surfactant.

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This study aims to explore the relationship between serum soluble interleukin-2 receptor alpha (sIL-2Rα) levels and histologic features in immunoglobin A nephropathy (IgAN), and evaluate its predicting values on disease progression and remission status. IgAN patients were included retrospectively. Lee classification, Oxford classification and histological scoring were evaluated.

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  • Research seeks to improve chemotherapy and PD-1 inhibitors for advanced non-small-cell lung cancer (NSCLC) by analyzing circulating tumor DNA (ctDNA) from 460 patients in the CHOICE-01 study.
  • Key predictive markers such as ctDNA status, tumor mutational burden, and chromosomal instability were identified to tailor treatment strategies for better patient outcomes.
  • An integrated ctDNA-based stratification system, called blood-based genomic immune subtypes (bGIS), offers a new way to personalize therapies and monitor treatment responses in advanced NSCLC patients.
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Objective: Pregnancy-induced hypertension (PIH) is a common disease during pregnancy, which arises from maternal placental vascular endothelial cell dysfunction. Growth differentiation factor 15 (GDF-15) has a protective effect on the cardiovascular system. The purpose of this study is to explore the protective effect of GDF-15 against hypoxia-reoxygenation (H/R)-induced damage to human placental vascular endothelial cells (HPVECs) and the regulatory mechanism of SIRT1 in this effect.

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Microelectrode arrays (MEAs) enable simultaneous measurement of spike trains from numerous neurons, owing to advancements in microfabrication technology. These probes are highly valuable for comprehending the intricate dynamics of neuronal networks. Spike sorting is a pivotal step in comprehensively analyzing the activity of neuronal networks from extracellular recordings.

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A wideband dual-beam dielectric resonator antenna (DRA) with substrate integration capability was proposed for millimeter-wave (mm-wave) applications. The four rows of air vias along the -direction and two extended rectangular patches could shift the undesirable radiation mode upward and move the conical-beam radiation mode downward, respectively. Thus, the TE mode and the TE mode of the patch-loaded perforated rectangular substrate integrated dielectric resonator (SIDR) supporting the dual-beam radiation can be retained in the operating band, and their radiation can be improved by the air vias along the -direction.

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Post-thrombotic syndrome (PTS) is one of the most common long-term complications of lower extremity deep vein thrombosis (DVT). In order to study the long-term adverse prognosis of patients with DVT, explore the influencing factors for the prognosis of DVT, and provide a reliable reference for future research in the field of venous thrombosis, we collected and summarized information about the incidence of PTS, the PTS score and grading, the associated symptoms and drug-related adverse reactions in 501 patients with DVT. In our study, 54.

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Rapid urbanization increases psychological stress among pedestrians, potentially heightening mental health disorders. This study examines the role of street walls' visual and textural characteristics in stress recovery, using Qingdao as a case study. Virtual reality is employed to simulate five distinct street walls: yellow mortar, brown stone, red brick, green plant, and white mortar.

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