Publications by authors named "Jin Seok Lee"

Background: Hepatic metastasis is the primary cause of colorectal cancer (CRC)-induced death. Our previous results showed the anti-metastatic effects of Coptidis rhizoma using in vitro model.

Aim: The present study aimed to investigate whether berberine, the main active compound of C.

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Hepatic organoids (HOs), primarily composed of hepatobiliary cells, do not represent the pathogenesis of liver diseases due to the lack of non-parenchymal cells. Multi-lineage liver organoids (mLOs) containing various cell types found in the liver offer a promising in vitro disease model. However, their structural complexity remains challenging to achieve due to the difficulty in optimizing culture conditions that meet the growth need of all component cell types.

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  • A study found that meditation helps reduce feelings of tiredness and fatigue, making it a good option for people who have trouble sleeping.
  • Researchers looked at 29 different trials involving over 4,000 participants and found that after about 9 weeks of meditation, people felt significantly less tired.
  • The best results were seen in those who felt a little unhealthy and for those dealing with mental fatigue, especially when they had guidance during their practice.
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  • Long COVID is characterized by persistent fatigue, and this study explored the effectiveness of Myeloph (MYP) in alleviating this symptom using a group of subjects with significant fatigue scores.
  • Participants (49) took 2,000 mg of MYP daily for 4 weeks, leading to notable reductions in fatigue levels and improvements in quality of life metrics.
  • The results suggest MYP could help manage fatigue from Long COVID, but more extensive studies are needed to confirm these findings.
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  • Not getting enough sleep can really mess with how we learn and remember things, especially in kids.
  • A study with mice showed that if they didn't sleep well early in life, they had trouble with long-term memory later on, even when they were adults.
  • The trouble with memory was linked to changes in a part of the brain called the hippocampus that helps with learning, showing that poor sleep can have lasting effects.
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  • ME/CFS is a serious illness that makes people very tired, affecting about 1 out of every 100 people worldwide, and it's hard for doctors to measure how tired someone really feels.
  • Researchers looked at 60 studies with over 7,000 ME/CFS patients to understand how bad their fatigue was and found that most had a fatigue level of about 78 out of 100.
  • The study showed that fatigue can be different for people based on their age, the type of treatments they receive, and how their fatigue is measured.
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Purpose: The increase in thyroid cancer incidence has inevitably led to an increase in thyroid cancer surgeries. This meta-regression analysis aimed to determine if the rate of post-thyroidectomy complications changes by year.

Materials And Methods: PubMed and Embase databases were used to perform a systematic literature search of studies published from January 1, 2005, using the keywords "thyroidectomy" and "complication.

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  • - Neoadjuvant chemotherapy using cisplatin is the typical treatment for serious bladder cancer, and combining it with immune therapy has shown good results in some patients.
  • - In a trial called LCCC1520, 22 out of 39 patients with muscle-invasive bladder cancer improved after receiving a treatment that combined chemotherapy and an immune drug.
  • - Scientists found that certain markers in blood and tumors could help predict which patients will respond well to this combined treatment, suggesting ways to tailor care for better outcomes.
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The high risk of neurological disorders in postmenopausal women is an emerging medical issue. Based on the hypothesis of altered estrogen receptors (ERα and β) after the decline of estrogen production, we investigated the changes in ERs expressions across brain regions and depressive/amnesic behaviors. C57BL/6J female mice were ovariectomized (OVX) to establish a menopausal condition.

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Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) is a heterogeneous disorder with elusive causes, but most likely because of clinical and other biological factors. As a vital environmental factor, the gut microbiome is increasingly emphasized in various refractory diseases including ME/CFS. The present study is aimed to enhance our understanding of the relationship between the gut microbiome and ME/CFS through data analysis of various clinical studies.

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Background: Long COVID is defined by persistent symptoms following COVID-19 infection. Approximately 71% of individuals with long COVID experience ongoing fatigue, postexertional malaise, and cognitive impairments, which share pathological similarities with myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS). This similarity has prompted studies to explore the characteristics of long COVID to gain a better understanding of ME/CFS.

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The hippocampal memory deficit stands out as a primary symptom in neurodegenerative diseases, including Alzheimer's disease. While numerous therapeutic candidates have been proposed, they primarily serve to delay disease progression. Given the irreversible brain atrophy or injury associated with these conditions, current research efforts are concentrated on preventive medicine strategies.

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Background: While the effect of gatekeeping was extensively studied, few efforts have been made to explain why the measures to strengthen gatekeeping do not work well in some countries. This study examined the patient factors related to the choice of level of health care facilities for outpatient care in Korea.

Methods: We examined a population-based sample representative of the population of Korea aged 15 and over in the healthcare experience survey of 2021.

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Objective: Fatigue is a common symptom in both irritable bowel syndrome (IBS) and inflammatory bowel disease (IBD), including Crohn's disease (CD) and ulcerative colitis (UC). This study aimed to distinguish fatigue characteristics in IBS and IBD, two functional and organic disorders.

Methods: We systematically searched the PubMed and Cochrane Library databases from inception to June 30, 2023, and conducted a meta-analysis to generate precise estimates and 95% confidence intervals.

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Objectives: Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a significant medical challenge, with no indisputable pathophysiological mechanism identified to date.

Methods: Based on clinical clues, we hypothesized that 5-hydroxytryptamine (5-HT) hyperactivation is implicated in the pathogenic causes of ME/CFS and the associated symptoms. We experimentally evaluated this hypothesis in a series of mouse models.

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The enzyme-linked immunosorbent spot (ELISpot) assay is a powerful in vitro immunoassay that enables cost-effective quantification of antigen-specific T-cell reactivity. It is used widely in the context of cancer and infectious diseases to validate the immunogenicity of predicted epitopes. While technological advances have kept pace with the demand for increased throughput, efforts to increase scale are bottlenecked by current assay design and deconvolution methods, which have remained largely unchanged.

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Ledeb., an important medicinal herb in traditional East Asian medicine, is primarily used to treat abdominal pain, dysentery, and hemostasis. There are ten other reported species of plants, including Nakai-a naturally growing species in South Korea-and Linn.

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Purpose: Focused parathyroidectomy is the gold standard treatment modality for primary hyperparathyroidism, which allows accurate preoperative localization. Robotic parathyroidectomy has emerged as a feasible procedure for focused parathyroidectomy. This study aimed to report the experiences of gasless robotic transaxillary parathyroidectomy for primary hyperparathyroidism in a single center.

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Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a debilitating condition characterized by an elusive etiology and pathophysiology. This study aims to evaluate the pathological role of neuroinflammation in ME/CFS by conducting an exhaustive analysis of 65 observational studies. Four neuroimaging techniques, including magnetic resonance imaging (MRI), magnetic resonance spectroscopy (MRS), electroencephalography (EEG), and positron emission tomography (PET), were employed to comparatively assess brain regional structure, metabolite profiles, electrical activity, and glial activity in 1529 ME/CFS patients (277 males, 1252 females) and 1715 controls (469 males, 1246 females).

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The purpose of this study was to investigate the effects of different peri-implantitis treatment methods (Er,Cr:YSGG laser, diode laser, and electrocautery) on various titanium implant surfaces: machined; sandblasted, large-grit, and acid-etched; and femtosecond laser-treated surfaces. Grade 4 titanium (Ti) disks, with a diameter of 10 mm and a thickness of 1 mm, were fabricated and treated using the aforementioned techniques. Subsequently, each treated group of disks underwent different peri-implantitis treatment methods: Er,Cr:YSGG laser (Biolase, Inc.

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Article Synopsis
  • Myalgic encephalitis/chronic fatigue syndrome (ME/CFS) is a disabling illness with unclear causes, and recent studies suggest that recovering from COVID-19 may trigger similar symptoms in some individuals.!* -
  • A systematic review and meta-analysis of 64 studies found that certain viral infections, particularly Borna disease virus (BDV), are significantly more prevalent in ME/CFS patients compared to healthy or other diseased controls.!* -
  • The findings highlight the potential role of viral infections in ME/CFS, providing a basis for further research into how these viruses could contribute to the condition's development.!*
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It is important to identify risk factors for post-thyroidectomy bleeding requiring airway intervention or reoperation. Therefore, we aimed to compare the characteristics of patients with postoperative bleeding after thyroid surgery according to the period until reoperation. We conducted a retrospective study analyzing data between April 2009 and July 2022 and included 126 patients who had postoperative bleeding.

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Introduction: Metachronous lateral neck recurrence after thyroidectomy for N1b papillary thyroid cancer is accompanied by high morbidity and increased difficulty of reoperation. From the perspective of recurrence, the objective of this study was to compare patients who underwent metachronous lateral neck dissection (mLND) despite initial thyroidectomy and patients who underwent synchronous lateral neck dissection (sLND) for papillary thyroid cancer and analyze the risk factors for recurrence after mLND.

Method: This retrospective study involved 1,760 patients who underwent lateral neck dissection for papillary thyroid cancer at the Gangnam Severance Hospital, a tertiary medical center in Korea, from June 2005 to December 2016.

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