Publications by authors named "Jin Ohkubo"
We recently reported that a neuronal population in the claustrum (CLA) identified under exposure to psychological stressors plays a key role in stress response processing. Upon stress exposure, the main inputs to the CLA come from the basolateral amygdala (BLA); however, the upstream brain regions that potentially regulate both the CLA and BLA during stressful experiences remain unclear. Here by combining activity-dependent viral retrograde labeling with whole brain imaging, we analyzed neurons projecting to the CLA and BLA activated by exposure to social defeat stress.
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- The study investigates the role of the claustrum (CLA) in managing stress and anxiety, revealing it as a key area for brain communication during stress responses.
- Researchers used advanced techniques like brain activation mapping and machine learning to show that CLA activation consistently indicates exposure to stress.
- The findings suggest that manipulating CLA activity can influence anxiety behaviors, with silencing the CLA during stress enhancing resilience against chronic stress effects.