Toward optimal inline respiratory motion correction for in vivo cardiac diffusion tensor MRI using symmetric and inverse-consistent deformable image registration.

Purpose: This study aims to develop a free-breathing cardiac DTI method with fast and robust motion correction.

Methods: Two proposed image registration-based motion correction (MOCO) strategies, MOCO and MOCO, were applied to diffusion-weighted images acquired with M2 diffusion gradients under free-breathing. The effectiveness of MOCO was assessed by tracking epicardium pixel positions across image frames.

Assessing reliability and comparability of 4D flow CMR whole heart measurements using retrospective valve tracking: A single-vendor study in the Berlin research network.

Introduction: This study investigated intracardiac flow dynamics and assessed the comparability and reliability of 4D flow CMR measurements across multiple sites within the Berlin Research Network for Cardiovascular Magnetic Resonance (BER-CMR) using 3D cine phase-contrast imaging with three-directional velocity encoding in a healthy traveling cohort.

Methods: In a prospective multi-site cohort study, 20 healthy volunteers underwent CMR at different sites. Quantitative assessment of Forward flow Volume (FFV), Peak (PV) and Mean Velocity (MV) across the heart's valves were conducted using retrospective valve tracking.

Patient-specific prediction of arterial wall elasticity using medical image-informed in-silico simulations.

Limitations in clinical cardiovascular research have driven the development of advanced simulations for patient-specific insights into arterial elasticity. However, uncertainties in model inputs, data resolution, and parameter estimation can compromise accuracy. Our research aimed to provide reliable estimates of the arterial wall elasticity non-invasively, where direct clinical measurement is difficult.

Feasibility of MRI-Guided Cardiac Catheterization, Angioplasty, and Stenting in a Commercial Wide-bore 0.55T Scanner.

Background: Low-field (0.55T) magnetic resonance imaging (MRI) may allow MRI-guided interventions using available catheterization equipment, as radiofrequency-induced heating of interventional devices is reduced at low field.

Objective: The purpose of this study was to test the feasibility of real-time MRI-guided right and left heart catheterization (R&LHC) as well as angioplasty and stenting of the inferior vena cava using a commercially available 0.

Niraparib restricts intraperitoneal metastases of ovarian cancer by eliciting CD36-dependent ferroptosis.

Ovarian cancer (OC) is prone to peritoneum or omentum dissemination, thus giving rise to the formidable challenge of unresectable surgery and a dismal survival rate. Although niraparib holds a pivotal role in the maintenance treatment of OC, its effect on suppressing metastases during primary intervention remains enigmatic. Recently, we initiated a prospective clinical study (NCT04507841) in order to evaluate the therapeutic efficacy of neoadjuvant niraparib monotherapy for advanced OC with homologous recombination deficiency.

Genes related to neural tube defects and glioblastoma.

There are many similarities between early embryonic development and tumorigenesis. The occurrence of neural tube defects (NTDs) and glioblastoma (GBM) are both related to the abnormal development of neuroectodermal cells. To obtain genes related to both NTDs and GBM, as well as small molecule drugs with potential clinical application value.

A Comprehensive Evaluation of Nutritional Quality and Antioxidant Capacity of Different Chinese Eggplant Varieties Based on Multivariate Statistical Analysis.

Free amino acids, polyphenols, and anthocyanins were quantified in 30 Chinese eggplant varieties. Moreover, antioxidant capacity characterizations including 2, 2'-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid) (ABTS), ferric-reducing antioxidant power (FRAP), and 2,2-diphenyl-1-picrylhydrazyl (DPPH) were performed. The total amino acid content of the 30 eggplant varieties ranged from 15,267.

Identification of the SP gene family and transcription factor SlSP5G promotes the high-temperature tolerance of tomatoes.

Some members of the SELF PRUNING (SP) gene family have been shown to play critical roles in developmental processes and stress responses across a wide range of plant species. The study identifies 13 members that can be divided into three subfamilies based on evolutionary analysis. Cis-Acting element analysis of the promoter regions indicated the presence of numerous stress- and hormone-responsive elements in the SlSP family.

Risk Factors Predicting Outcomes in Advanced Upper Gastrointestinal Cancers Treated With Immune Checkpoint Inhibitors.

Background: Immune checkpoint inhibitors (ICIs) have moved to the frontline in recent years to manage upper gastrointestinal (UGI) tumors, such as esophageal and gastric cancers. This retrospective review sheds light on real-world data on ICI-treated UGI tumors to identify risk factors (clinical and pathological) impacting the outcome other than traditional biomarkers (programmed cell death ligand 1 (PD-L1) or microsatellite instability status).

Methods: Patients with UGI tumors who received at least one dose of ICI for stage IV or recurrent disease between January 1, 2015, and July 31, 2021, at The Ohio State University were included in the study.

Image reconstruction impacts haemodynamic parameters derived from 4D flow magnetic resonance imaging with compressed sensing.

Aims: 4D blood flow measurements by cardiac magnetic resonance imaging (CMR) can be used to simplify blood flow assessment. Compressed sensing (CS) can provide better flow measurements than conventional parallel imaging (PI), but clinical validation is needed. This study aimed to validate stroke volume (SV) measurements by 4D-CS in healthy volunteers and patients while also investigating the influence of the CS image reconstruction parameter on haemodynamic parameters.

Human umbilical cord mesenchymal stem cells enhance liver regeneration and decrease collagen content in fibrosis mice after partial hepatectomy by activating Wnt/β-catenin signaling.

Liver fibrosis is a critical stage in the progression of various chronic liver diseases to cirrhosis and liver cancer. Early inhibition of liver fibrosis is crucial for the treatment of liver disease. Hepatectomy, a common treatment for liver-related diseases, promotes liver regeneration.

Performance of respiratory gated 4D flow MRI with adaptive k-space reordering in healthy controls and aortic dissection: reproducibility and agreement with 2D phase contrast MRI.

A four-dimensional phase-contrast magnetic resonance imaging sequence with respiratory-controlled adaptive k-space reordering (ReCAR-4DPC) offers potential benefits of improved scan efficiency and motion robustness. The purpose of this study was to evaluate the reproducibility of flow measurement using this technique and to compare hemodynamic metrics obtained to two-dimensional phase contrast MRI (2DPC)-derived metrics of the thoracic aorta. ReCAR-4DPC was performed with identical scan parameters in 15 healthy volunteers (6M,9F, mean [range] 37 [23-47] years) and 11 patients with thoracic aortic dissection (6M,5F, 56 [31-81] years) and acquisition time was recorded.

Diagnostic Value of Cerebrospinal Fluid Sequencing for Neurosyphilis with Cognitive Impairment.

Neurosyphilis (NS) is an infectious disease caused by invading the central nervous system. It can manifest at any stage of syphilis, and is often misdiagnosed due to its atypical and progressive symptoms. The increasing incidence of NS underscores the necessity for early and accurate diagnosis.

Silicon-seed priming promotes seed germination under CA-induced autotoxicity by improving sucrose and respiratory metabolism in cucumber (Cucumis sativus L.).

Seed germination is one of the critical and sensitive stages of early plant growth, and its process is prevented by cinnamic acid (CA). Silicon (Si) plays a critical role in mitigating abiotic stresses and seed germination in plants, but little is known about its role in seed germination and physiology in CA-stressed cucumber. Here, we conducted experiments in the State Key Laboratory of Aridland Crop Science, Gansu Agricultural University from March to June 2021 to investigate the effects of Si-seed priming on growth, antioxidant capacity, sucrose mobilization and respiratory metabolism during germination under CA stress.

Ultra-Thin Highly Sensitive Electronic Skin for Temperature Monitoring.

Electronic skin capable of reliable monitoring of human skin temperature is crucial for the advancement of non-invasive clinical biomonitoring, disease diagnosis, and health surveillance. Ultra-thin temperature sensors, with excellent mechanical flexibility and robustness, can conformably adhere to uneven skin surfaces, making them ideal candidates. However, achieving high sensitivity often demands sacrificing flexibility, rendering the development of temperature sensors combining both qualities a challenging task.

The E3 ligase OsPUB33 controls rice grain size and weight by regulating the OsNAC120-BG1 module.

Grain size and weight are important determinants of crop yield. Although the ubiquitin pathway has been implicated in the grain development in rice (Oryza sativa), the underlying genetic and molecular mechanisms remain largely unknown. Here, we report that the plant U-box E3 ubiquitin ligase OsPUB33 interferes with the OsNAC120-BG1 module to control rice grain development.

Riluzole Enhancing Anti-PD-1 Efficacy by Activating cGAS/STING Signaling in Colorectal Cancer.

Colorectal cancer is the second leading cause of cancer mortality in the United States. Although immune checkpoint blockade therapies including anti-PD-1/PD-L1 have been successful in treating a subset of patients with colorectal cancer, the response rates remain low. We have found that riluzole, a well-tolerated FDA-approved oral medicine for treating amyotrophic lateral sclerosis, increased intratumoral CD8+ T cells and suppressed tumor growth of colon cancer cells in syngeneic immune-competent mice.

4D-Flow MRI and Vector Ultrasound in the In-Vitro Evaluation of Surgical Aortic Heart Valves - a Pilot Study.

Introduction: The aim of this study was the initial investigation of 4D-Flow MRI and Vector Ultrasound as novel imaging techniques in the in-vitro analysis of hemodynamics in anatomical models. Specifically, by looking at the hemodynamic performance of state-of-the-art surgical heart valves in a 3D-printed aortic arch.

Methods: The mock circulatory loop simulated physiological, pulsatile flow.

[Distribution and health risk assessment of pesticide pollution in raw water and drinking water within key river basins in China in 2022].

Objective: To investigate the distribution and exposure levels of pesticides in raw water and drinking water in China, as well as to assess the potential health risks associated with long-term consumption.

Methods: A total of 83 typical water plants were selected in key river basins in China to collected samples of the raw water, finished water, and tap water. The online-solid phase extraction coupled with liquid chromatography-tandem mass spectrometry method was used to determine 13 pesticides, including acetochlor, atrazine, dimethoate, malathion, carbofuran, dichlorvos, chlorpyrifos, parathion, trifluralin, isoprothiolane, simetryn, methyl parathion, and metalaxyl, as well as 6 environmental metabolites, including carbendazim, malaoxon, 3-hydroxycarbofuran, deethyl atrazine, deisopropyl atrazine and hydroxy atrazine.

Assessing Cerebral Microvascular Volumetric Pulsatility with High-Resolution 4D CBV MRI at 7T.

Arterial pulsation is crucial for promoting fluid circulation and for influencing neuronal activity. Previous studies assessed the pulsatility index based on blood flow velocity pulsatility in relatively large cerebral arteries of human. Here, we introduce a novel method to quantify the volumetric pulsatility of cerebral microvasculature across cortical layers and in white matter (WM), using high-resolution 4D vascular space occupancy (VASO) MRI with simultaneous recording of pulse signals at 7T.

Mature MUC5AC Expression in Resected Pancreatic Ductal Adenocarcinoma Predicts Treatment Response and Outcomes.

Neoadjuvant therapy (NAT) for early-stage pancreatic ductal adenocarcinoma (PDA) has recently gained prominence. We investigated the clinical significance of mucin 5 AC (MUC5AC), which exists in two major glycoforms, a less-glycosylated immature isoform (IM) and a heavily glycosylated mature isoform (MM), as a biomarker in resected PDA. Immunohistochemistry was performed on 100 resected PDAs to evaluate the expression of the IM and MM of MUC5AC using their respective monoclonal antibodies, CLH2 (NBP2-44455) and 45M1 (ab3649).