Improving sulforaphane content in broccoli sprouts by applying Se: transcriptome profiling and coexpression network analysis provide insights into the mechanistic response.

Sulforaphane (SF) is a sulfur (S)-containing isothiocyanate found in cruciferous vegetables and is known for its potent anticancer properties. Broccoli sprouts, in particular, are considered safe and healthy dietary choices due to their high SF content and other beneficial biological activities, such as enhanced metabolite ingestion. The application of selenium (Se) is an excellent approach to enhance the abundance of SF.

Impacts of enhanced recovery after surgery nursing interventions on wound infection and complications following bladder cancer surgery: A meta-analysis.

A meta-analysis was executed to comprehensively examine the impacts of enhanced recovery after surgery (ERAS) care interventions on complications and wound infections following bladder cancer (BCa) surgery. Computer searches were carried out in Embase, Google Scholar, Cochrane Library, PubMed, Wanfang and CNKI, from their inception to November 2023, for RCTs regarding perioperative ERAS nursing interventions in patients with BCa. Two independent researchers performed literature screening, extracted data and carried out quality evaluations.

VDRA downregulate β-catenin/Smad3 and DNA damage and repair associated with improved prognosis in ccRCC patients.

The clear cell renal cell carcinoma (ccRCC) spotlighted the poorest survival, while chromophobe renal cell carcinoma (chRCC) was associated with the best survival. Earlier studies corroborated vitamin D receptor (VDR) was a promising molecular for improving the prognosis of RCC. In contrast to VDRA, the one of VDR isoforms, VDRB1 (VDR isoform B1) has an N-terminal extension of 50 amino acids and is less ligand-dependent.

Refractory alopecia areata with single hairs imitating frontal fibrosing alopecia: a prospective observational study.

Background: Lonely hair sign is considered as a clue to the diagnosis of frontal fibrosing alopecia (FFA).

Objective: To report an undescribed variant of alopecia areata (AA) with which the patient developed single hairs and other features similar to FFA and to determine the underlying mechanism.

Methods: We conducted a prospective observational study in patients who presented with receding hairline and single hairs, evaluating the clinical, trichoscopic, and histological features and their correlation.

-methyladenosine modification contributes to respiratory syncytial virus infection.

Background: Respiratory syncytial virus (RSV) is the second leading cause of death due to lower respiratory tract infections. Effective prevention and treatment measures are lacking, posing a huge socioeconomic burden to the world. -methyladenosine (mA) is the most common internal modification in messenger RNA and noncoding RNA.

Evaluation of the prognostic nutritional index for the prognosis of Chinese patients with high/extremely high-risk prostate cancer after radical prostatectomy.

Background: The incidence of prostate cancer (PCa) is on the rise in China. The risk level of patients with PCa is associated with disease-free survival rate at 10 years after radical prostatectomy. Predicting prognosis in advance according to the degree of risk can provide a reference for patients, especially treatment options and postoperative adjuvant treatment measures for high-risk/extremely high-risk patients.

Integrated Trinity Test With RPA-CRISPR/Cas12a-Fluorescence for Real-Time Detection of Respiratory Syncytial Virus A or B.

Respiratory syncytial virus (RSV) is a common virus that causes respiratory infection, especially severe respiratory infection in infants and young children, the elderly people over 65 years old, and people with weak immunity. Currently, RSV infection has no effective vaccine and antiviral treatment. The number of deaths due to RSV infection increases every year.

Bioinformatics Analysis of mRNAs and miRNAs for Identifying Potential Biomarkers in Lung Adenosquamous Carcinoma.

Background: Lung adenosquamous carcinoma (LASC) is a special type of lung cancer. LASC is a malignant tumor with strong aggressiveness and a poor prognosis. Previous studies have revealed that microRNAs (miRNAs) are widely involved in the development of tumors by targeting mRNA.

Realistic Reference for Evaluation of Vehicle Safety Focusing on Pedestrian Head Protection Observed From Kinematic Reconstruction of Real-World Collisions.

Head-to-vehicle contact boundary condition and criteria and corresponding thresholds of head injuries are crucial in evaluation of vehicle safety performance for pedestrian protection, which need a constantly updated understanding of pedestrian head kinematic response and injury risk in real-world collisions. Thus, the purpose of the current study is to investigate the characteristics of pedestrian head-to-vehicle contact boundary condition and pedestrian AIS3+ (Abbreviated Injury Scale) head injury risk as functions of kinematic-based criteria, including HIC (Head Injury Criterion), HIP (Head Impact Power), GAMBIT (Generalized Acceleration Model for Brain Injury Threshold), RIC (Rotational Injury Criterion), and BrIC (Brain Injury Criteria), in real-world collisions. To achieve this, 57 vehicle-to-pedestrian collision cases were employed, and a multi-body modeling approach was applied to reconstruct pedestrian kinematics in these real-world collisions.

Pedestrian dynamic response and injury risk in high speed vehicle crashes.

Purpose: The purpose of the current study is to understand pedestrian kinematics, biomechanical response and injury risk in high speed vehicle crashes.

Methods: Vehicle-to-pedestrian crashes at the impact speeds of 40 km/h (reference set) and 70 km/h (analysis set) were simulated employing FE models of a sedan front and an SUV front together with a pedestrian FE model developed using hollow structures. The predictions from crash simulations of different vehicle types and impact speeds were compared and analyzed.

Deep Learning-based Trichoscopic Image Analysis and Quantitative Model for Predicting Basic and Specific Classification in Male Androgenetic Alopecia.

Since the results of basic and specific classification in male androgenetic alopecia are subjective, and trichoscopic data, such as hair density and diameter distribution, are potential quantitative indicators, the aim of this study was to develop a deep learning framework for automatic trichoscopic image analysis and a quantitative model for predicting basic and specific classification in male androgenetic alopecia. A total of 2,910 trichoscopic images were collected and a deep learning framework was created on convolutional neural networks. Based on the trichoscopic data provided by the framework, correlations with basic and specific classification were analysed and a quantitative model was developed for predicting basic and specific classification using multiple ordinal logistic regression.

Identification of Immune-Related Prognostic Biomarkers Associated with HPV-Positive Head and Neck Squamous Cell Carcinoma.

Background: As a type of malignant tumor, head and neck squamous cell carcinoma (HNSCC) seriously threatens human health. This study is aimed at constructing a new, reliable prognostic model.

Method: The gene expression profile data of HNSCC patients were downloaded from the Gene Expression Omnibus and The Cancer Genome Atlas databases.

Predicting pedestrian lower limb fractures in real world vehicle crashes using a detailed human body leg model.

Purpose: The purpose of this study was to evaluate the capability of a detailed FE human body lower limb mode, called HALL (Human Active Lower Limb) model, in predicting real world pedestrian injuries and to investigate injury mechanism of pedestrian lower limb in vehicle collisions.

Methods: Two real world vehicle-to-pedestrian crashes with detailed information were selected. Then, a pedestrian model combining the HALL model and the upper body of the 50th% Chinese dummy model and vehicle front models were developed to reconstruct the selected real world crashes, and the predictions of the simulations were analyzed together with observations from the accident data.

A semiquantitative grading scale for frontal and vertex of androgenetic alopecia.

Background: Depending on the severity and region of baldness, numerous researchers proposed different classifications of alopecia. However, these previous classifications have some limitations. The study aimed to establish a semiquantitative grading scale for frontal and vertex androgenetic alopecia (AGA) in both males and females.

Novel Li[(CFSO)(n-CFSO)N]-Based Polymer Electrolytes for Solid-State Lithium Batteries with Superior Electrochemical Performance.

Solid polymer electrolytes (SPEs) would be promising candidates for application in high-energy rechargeable lithium (Li) batteries to replace the conventional organic liquid electrolytes, in terms of the enhanced safety and excellent design flexibility. Herein, we first report novel perfluorinated sulfonimide salt-based SPEs, composed of lithium (trifluoromethanesulfonyl)(n-nonafluorobutanesulfonyl)imide (Li[(CFSO)(n-CFSO)N], LiTNFSI) and poly(ethylene oxide) (PEO), which exhibit relatively efficient ionic conductivity (e.g.

Single Lithium-Ion Conducting Polymer Electrolytes Based on a Super-Delocalized Polyanion.

A novel single lithium-ion (Li-ion) conducting polymer electrolyte is presented that is composed of the lithium salt of a polyanion, poly[(4-styrenesulfonyl)(trifluoromethyl(S-trifluoromethylsulfonylimino)sulfonyl)imide] (PSsTFSI(-)), and high-molecular-weight poly(ethylene oxide) (PEO). The neat LiPSsTFSI ionomer displays a low glass-transition temperature (44.3 °C; that is, strongly plasticizing effect).

The role of transcription factors of neurosensory cells in non-syndromic sensorineural hearing loss with or without inner ear malformation.

Conclusions: Previous studies have stated the roles and correlation of the four TFs (Sox2, Atoh1, Neurog1, and Neurod1) in the development of neurosensory cells. but whether they are inherited pathogenic factors to cause non-syndromic sensorineural hearing loss is unknown so far. This is the first time for screening the Sox2, Atoh1, Neurog1, and Neurod1 genes in children with NSHL.

A study of bicyclist kinematics and injuries based on reconstruction of passenger car-bicycle accident in China.

Like pedestrians, bicyclists are vulnerable road users, representing a population with a high risk of fatal and severe injuries in traffic accidents as they are unprotected during vehicle collisions. The objective of this study is to investigate the kinematics response of bicyclists and the correlation of the injury severity with vehicle impact speed. Twenty-four car-bicyclist cases with detailed information were selected for accident reconstruction using mathematical models, which was implemented in the MADYMO program.

A study of fatality risk and head dynamic response of cyclist and pedestrian based on passenger car accident data analysis and simulations.

Objective: The current study aims to compare the fatality risk of pedestrians and cyclists in urban traffic through an analysis of real-world accident data in China.

Methods: First, 438 cases, including 371 pedestrian cases and 67 cyclist cases, were selected as a sample from the accidents collected through an in-depth investigation of vehicle accidents in China. A statistical measurement of the fatality risk with respect to impact velocity was carried out using a logistic regression analysis.

Neopterin negatively regulates expression of ABCA1 and ABCG1 by the LXRα signaling pathway in THP-1 macrophage-derived foam cells.

To investigate the effects of neopterin on ABCA1 expression and cholesterol efflux in human THP-1 macrophage-derived foam cells, and to explore the role of the liver X receptor alpha (LXRα) involved. In the present study, THP-1 cells were pre-incubated with ox-LDL to become foam cells. The protein and mRNA expression were examined by Western blot assays and real-time quantitative PCR, respectively.

WITHDRAWN: Kidney injury molecule-1: a novel kidney-specific injury molecule playing potential double-edged functions in kidney injury.

Ahead of Print article withdrawn by Publisher. Kidney injury molecule-1 (KIM-1), a recently discovered transmembrane protein, is expressed in dedifferentiated renal proximal tubular epithelial cells in damaged regions. Many studies have confirmed that KIM-1 is a specific marker of renal proximal tubular damage.