Publications by authors named "Jin Myoung Seok"

Article Synopsis
  • Researchers studied the quality of life (QOL) of patients with a condition called MOGAD and compared it to another condition called AQP4-IgG positive NMOSD.
  • They found that the overall QOL was similar between both groups, but many patients in both groups struggled with sleep, pain, and feelings of sadness.
  • The study suggests that both conditions need more focus on improving sleep and mental health to help patients feel better overall.
View Article and Find Full Text PDF
Article Synopsis
  • Aseptic meningitis is characterized by inflammation of the meninges and changes in cerebrospinal fluid, without positive bacterial tests, and this study focuses on the viral causes, particularly herpes simplex virus type 2 (HSV-2), in immunocompetent adults.
  • The research analyzed 98 patients at a Korean hospital diagnosed with aseptic meningitis over two years, finding that HSV-2 accounted for 16.3% of cases, alongside other viruses like enterovirus and varicella zoster virus.
  • Key findings suggested that HSV-2 predominantly affects females and is associated with higher white blood cell counts and protein levels in cerebrospinal fluid, while prior meningitis history and serum C-reactive protein levels were
View Article and Find Full Text PDF
Article Synopsis
  • Neuromyelitis optica spectrum disorder (NMOSD) is a central nervous system disease that differs from multiple sclerosis by the presence of anti-aquaporin 4 antibodies (AQP4-ab) and occasionally other non-organ-specific autoantibodies.
  • A study involving 158 NMOSD patients collected data on various autoantibodies and analyzed their impact on clinical characteristics and disability levels.
  • Results indicated that the rheumatoid factor (RF) was significantly associated with higher disability levels; RF, age at onset, and annual relapse rate (ARR) emerged as key predictors for severe disability in NMOSD patients.
View Article and Find Full Text PDF
Article Synopsis
  • A study investigated the impact of the timing of treatment for the first acute attack of myelin oligodendrocyte glycoprotein antibody-associated disease (MOGAD) on long-term relapse risk and conversion to MOG-IgG seronegative status.
  • Conducted in South Korea, the research involved a cohort of 240 adults diagnosed with MOGAD, focusing on their treatment timing categorized as early, intermediate, or late.
  • Results indicated that 45.8% of patients experienced relapses and 25% converted to seronegative MOG-IgG, highlighting the potential significance of timely treatment in managing MOGAD.
View Article and Find Full Text PDF

Numerous neuroimmunological disorders present with sleep-related symptoms. The identification of novel autoantibodies introduces new clinical categories in autoimmune diseases of the central nervous system and generates interest in the dynamic interaction between sleep and the immune system. In this review, the complex relationship among sleep, immune regulation, and neuroimmunological disorders was examined with emphasis on the vital role of sleep in modulating immune function and its influence on these conditions, This relationship emphasizes the importance of assessments and management of sleep quality in the treatment approaches for neuroimmunological disorders.

View Article and Find Full Text PDF
Article Synopsis
  • Rare diseases are mostly genetic and often have neurological symptoms, making their diagnosis and treatment complicated due to their rarity and low prevalence.
  • A national registry has been established in Korea to focus on three specific rare diseases that cause gait disturbances, collecting clinical data and biological materials from patients.
  • The registry aims to identify genetic variants specific to Korean patients and discover biomarkers to improve early diagnosis and treatment development for these conditions.
View Article and Find Full Text PDF

Background: Myelin oligodendrocyte glycoprotein antibody (MOG) immunoglobulin G (IgG)-associated disease (MOGAD) has clinical and pathophysiological features that are similar to but distinct from those of aquaporin-4 antibody (AQP4-IgG)-positive neuromyelitis optica spectrum disorders (AQP4-NMOSD). MOG-IgG and AQP4-IgG, mostly of the IgG1 subtype, can both activate the complement system. Therefore, we investigated whether the levels of serum complement components, regulators, and activation products differ between MOGAD and AQP4-NMOSD, and if complement analytes can be utilized to differentiate between these diseases.

View Article and Find Full Text PDF

This study evaluates the antibody responses to SARS-CoV-2 vaccines in patients with neuroimmunological disorders (pwNID) who are receiving immunomodulating treatments, compared to healthy individuals. It included 25 pwNID with conditions such as optic neuritis, neuromyelitis optica spectrum disorder, multiple sclerosis, myasthenia gravis, and polymyositis, as well as 56 healthy controls. All participants had completed their full SARS-CoV-2 vaccination schedule, and their blood samples were collected within six months of their last dose.

View Article and Find Full Text PDF

Background And Aims: Scrub typhus is an endemic disease in the fall season that occurs in a limited number of places known as the Tsutsugamushi Triangle. Peripheral neuropathy is a common complication of scrub typhus. Herein, we encountered several patients with ascending paralysis after scrub typhus infection, who were diagnosed with Guillain-Barré syndrome (GBS).

View Article and Find Full Text PDF

Background: Serum levels of neurofilament light chain (NfL) and glial fibrillary acidic protein (GFAP) reflect the disease activity and disability in central nervous system (CNS) demyelinating diseases. However, the clinical significance of NfL and GFAP in idiopathic transverse myelitis (iTM), an inflammatory spinal cord disease with unknown underlying causes, remains unclear. This study aimed to investigate NfL and GFAP levels in iTM and their association with the clinical parameters compared with those in TM with disease-specific antibodies such as anti-aquaporin 4 or myelin oligodendrocyte glycoprotein antibodies (sTM).

View Article and Find Full Text PDF

Background: The clinical implications of myelin oligodendrocyte glycoprotein autoantibodies (MOG-Abs) are increasing. Establishing MOG-Ab assays is essential for effectively treating patients with MOG-Abs. We established an in-house cell-based assay (CBA) to detect MOG-Abs to identify correlations with patients' clinical characteristics.

View Article and Find Full Text PDF

Multiple sclerosis (MS) and neuromyelitis optica spectrum disorder (NMOSD) are autoimmune inflammatory disorders of the central nervous system (CNS) with similar characteristics. The differential diagnosis between MS and NMOSD is critical for initiating early effective therapy. In this study, we developed a deep learning model to differentiate between multiple sclerosis (MS) and neuromyelitis optica spectrum disorder (NMOSD) using brain magnetic resonance imaging (MRI) data.

View Article and Find Full Text PDF
Article Synopsis
  • The study focused on detecting myelin oligodendrocyte glycoprotein autoantibodies (MOG-Ab), crucial for diagnosing MOG-Ab-associated disease (MOGAD), and explored the clinical implications of different recognized epitopes.
  • Researchers created a cell-based immunoassay to identify MOG-Ab epitopes and conducted a retrospective review of 55 patients in a registry, evaluating their serum samples.
  • Key findings revealed that the P42 epitope in MOG is a significant target for MOG-Ab, primarily associated with monophasic disease and childhood onset in affected patients, highlighting the need for further research on MOG-Ab's predictive value and epitopes.
View Article and Find Full Text PDF

Experimental autoimmune encephalomyelitis (EAE) is an animal model of Inflammatory central nervous system (CNS) disease. Dark agouti (DA) rats immunized with full-length myelin oligodendrocyte glycoprotein (MOG) typically develop a relapsing-remitting EAE form characterized by predominant demyelinating involvement of the spinal cord and optic nerve. Visually evoked potentials (VEP) are a useful objective tool to assess the optic nerve function and monitor electrophysiological changes in optic neuritis (ON).

View Article and Find Full Text PDF

Background: Neuromyelitis optica spectrum disorder (NMOSD) causes relapsing inflammatory attacks in the central nervous system, leading to disability. As rituximab, a B-lymphocyte-depleting monoclonal antibody, is an effective in preventing NMOSD relapses, we hypothesised that earlier initiation of rituximab can also reduce long-term disability of patients with NMOSD.

Methods: This multicentre retrospective study involving 19 South Korean referral centres included patients with NMOSD with aquaporin-4 antibodies receiving rituximab treatment.

View Article and Find Full Text PDF

Increasing evidence suggests an association between SARS-CoV-2 vaccines and Guillain-Barré syndrome (GBS). Nevertheless, little is understood about the contributing risk factors and clinical characteristics of GBS post SARS-CoV-2 vaccination. In this prospective surveillance study of 38,828,691 SARS-CoV-2 vaccine doses administered from February 2021 to March 2022 in the Gyeonggi Province, South Korea, 55 cases of GBS were reported post vaccination.

View Article and Find Full Text PDF

Background: In the present study, it was investigated whether autonomic dysfunction could predict prognosis in light-chain (AL) amyloidosis patients.

Patients And Methods: Seventy-two patients with biopsy-proven AL amyloidosis were included and underwent an autonomic function test (AFT) between January 2016 and June 2019. Autonomic failure was evaluated using the Composite Autonomic Severity Score (CASS).

View Article and Find Full Text PDF

Background And Purpose: Neuromyelitis optica spectrum disorder (NMOSD) is a rare demyelinating disease of the central nervous system (CNS). We investigated the medical behaviors of experts in Korea when they are diagnosing and treating NMOSD.

Methods: An anonymous questionnaire on the diagnosis and treatment of NMOSD was distributed to experts in CNS demyelinating diseases.

View Article and Find Full Text PDF

Although fatigue is a major symptom in patients with neuromyelitis optica spectrum disorder (NMOSD), the underlying mechanism remains unclear. We explored the relationship between subcortical structures and fatigue severity to identify neural substrates of fatigue in NMOSD. Clinical characteristics with brain magnetic resonance imaging were evaluated in forty patients with NMOSD.

View Article and Find Full Text PDF

Purpose: The composite autonomic symptom scale-31 (COMPASS-31) is a self-rated questionnaire that evaluates diverse autonomic symptoms. In the present study, we developed the Korean version of the COMPASS-31 (K-COMPASS-31) with appropriate translation, and verified its reliability and internal and external validity in patients with Parkinson's disease (PD).

Methods: The original COMPASS-31 was translated independently into Korean by two bilingual neurologists.

View Article and Find Full Text PDF

Previous efforts to discover new surrogate markers for the central nervous system (CNS) inflammatory demyelinating disorders have shown inconsistent results; moreover, supporting evidence is scarce. The present study investigated the IgG autoantibody responses to various viral and autoantibodies-related peptides proposed to be related to CNS inflammatory demyelinating disorders using the peptide microarray method. We customized a peptide microarray containing more than 2440 immobilized peptides representing human and viral autoantigens.

View Article and Find Full Text PDF