Publications by authors named "Jin Koung Kim"
Oxysterol sulfation plays an important role in regulation of lipid metabolism and inflammatory responses. In the present study, we report the discovery of a novel regulatory sulfated oxysterol in nuclei of primary rat hepatocytes after overexpression of the gene encoding mitochondrial cholesterol delivery protein (StarD1). Forty-eight hours after infection of the hepatocytes with recombinant StarD1 adenovirus, a water-soluble oxysterol product was isolated and purified by chemical extraction and reverse-phase HPLC.
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- SREBP-1c promotes fat production in the liver, and its activity is boosted by LXRα, contributing to nonalcoholic fatty liver disease (NAFLD) progression.
- A compound called 25HC3S blocks LXRα signaling, leading to reduced SREBP-1c levels and subsequently lowering fat production in the liver.
- In mouse models of NAFLD, 25HC3S treatment not only decreased fat buildup and inflammation but also improved insulin sensitivity, highlighting its potential as a protective agent against liver fat accumulation and related issues.
25-Hydroxycholesterol-3-sulfate attenuates inflammatory response via PPARγ signaling in human THP-1 macrophages.
Am J Physiol Endocrinol Metab
April 2012
The nuclear receptor peroxisome proliferator-activated receptors (PPARs) are important in regulating lipid metabolism and inflammatory responses in macrophages. Activation of PPARγ represses key inflammatory response gene expressions. Recently, we identified a new cholesterol metabolite, 25-hydroxycholesterol-3-sulfate (25HC3S), as a potent regulatory molecule of lipid metabolism.
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