MANAGEMENT OF VITREAL LOSS FROM POSTERIOR CAPSULAR RUPTURE DURING CATARACT OPERATION: Posterior Versus Anterior Vitrectomy.

Purpose: To compare the efficacy between 23-gauge sutureless pars planar vitrectomy (PPV) and anterior vitrectomy in the management of vitreous loss associated with posterior capsular rupture during cataract surgery.

Methods: Medical records of 139 eyes which sustained posterior capsular rupture and vitreal prolapse to anterior chamber during cataract surgery were retrospectively reviewed. Thirty-two eyes which underwent 23-gauge sutureless PPV (group PPV) and 107 eyes which underwent anterior vitrectomy (group AntV) were compared in postoperative visual and anatomical outcomes, operation time, and complications.

A novel color vision test for detection of diabetic macular edema.

Purpose: To determine the sensitivity of the Seoul National University (SNU) computerized color vision test for detecting diabetic macular edema.

Methods: From May to September 2003, a total of 73 eyes of 73 patients with diabetes mellitus were examined using the SNU computerized color vision test and optical coherence tomography (OCT). Color deficiency was quantified as the total error score on the SNU test and as error scores for each of four color quadrants corresponding to yellows (Q1), greens (Q2), blues (Q3), and reds (Q4).

Partial visual rehabilitation using a toric implantable collamer lens in a patient with keratoconus: a case report with 20 months of follow-up.

We report the case of a 37-year-old man with a high myopic keratoconus eye that was treated with a posterior chamber toric implantable collamer lens (ICL) in Korea. The patient had a history of contact lens intolerance and did not want to have a corneal transplantation. His uncorrected visual acuity (UCVA) and best spectacle corrected visual acuity were 0.

A novel computerized visual acuity test for children.

Purpose: To investigate the efficacy of a computerized visual acuity test, the SNU visual acuity test for children.

Methods: Fifty-six children, ranging from 1 to 5 years of age, were included. In a dark room, children gazed at and followed a circular dot with 50% contrast moving at a fixed velocity of 10 pixels/sec on a computer monitor.

Effects of a novel push-through technique using the implantable collamer lens injector system for graft delivery during endothelial keratoplasty.

Purpose: To investigate effects of a new push-through insertion method for donor lenticules using an injector system on endothelial viability ex vivo and in a clinical case series of endothelial keratoplasty.

Methods: An ex vivo delivery model was used with porcine corneoscleral rims. We compared the endothelial viability in a new push-through insertion method using the Visian Implantable Collamer Lens (ICL) injector versus that of standard forceps-assisted insertion for lenticule delivery.

VSX1 gene and keratoconus: genetic analysis in Korean patients.

Purpose: The visual system homeobox 1 (VSX1) gene variants have recently been shown to be associated with keratoconus. To replicate this finding, we performed a genetic analysis of the VSX1 gene in a Korean case-control sample.

Methods: Patients with keratoconus and healthy control subjects were recruited from Seoul National University Hospital.

Cysteamine prevents the development of lens opacity in a rat model of selenite-induced cataract.

Purpose: The activation of transglutaminase 2 (TG2) by oxidative stress through TGFβ has been reported to play a crucial role in cataract formation. The authors investigated whether TG2 is involved in selenite-induced cataract formation in rats and whether cysteamine, a chemical inhibitor of TG2, can prevent cataract formation in this model.

Methods: Intracellular TG2 activity was monitored in a human lens epithelial cell (HLE-B3) line and cultured rat lenses after treatment with selenite.

Juvenile xanthogranuloma presenting as infiltrative conjunctival mass in an adult.

Purpose: To report on the clinical and histopathologic findings of a conjunctival juvenile xanthogranuloma in an adult.

Methods: Case report and literature review.

Results: A 43-year-old man developed 2 yellowish conjunctival lumps not associated with other ocular or systemic findings.

Cosmetic improvement of nevus of Ota by scleral allograft overlay.

Objective: To report surgical outcome of a new therapeutic technique for nevus of Ota by scleral allograft overlay.

Design: Noncomparative clinical interventional study.

Participants: Eight eyes of 7 patients with scleral nevus of Ota.

Vortex keratopathy in a patient receiving vandetanib for non-small cell lung cancer.

We report a case of vortex keratopathy in a patient treated with vandetanib for non-small cell lung cancer (NSCLC). A 44-year-old female who underwent two cycles of chemotherapy for NSCLC complained of visual blurring in both eyes after the initiation of vandetanib, an anti-epidermal growth factor receptor (EGFR) and anti-vascular endothelial growth factor receptor 2 protein tyrosine kinase inhibitor. On ophthalmic examination, visual acuities were 20 / 20 OU and, with the exception of diffuse vortex keratopathy in both eyes, other findings were unremarkable.

Five-year results of corneal tattooing for cosmetic repair in disfigured eyes.

Purpose: To investigate the 5-year results of corneal tattooing for cosmetic repair in disfigured eyes and identify the risk factors associated with complications.

Methods: Corneal tattooing was performed in patients with stable corneal opacity and blind eyes. A total of 147 eyes of 147 patients who were followed up for at least 5 years after tattooing were enrolled in the study.

Efficacy of a computerized optokinetic nystagmus test in prediction of visual acuity of better than 20/200.

Purpose: To evaluate the efficacy of a computerized optokinetic nystagmus (OKN) test in detecting visual acuity (VA) of >20/200.

Methods: This was a combined retrospective and prospective, noninterventional study. In phase I of the study, data from 168 eyes of 154 subjects who underwent the computerized objective VA test using OKN responses at Seoul National University Bundang Hospital were reviewed and reanalyzed, and a table for predicting the range of subjective VA for each step of objective VA was made.

Long-term outcome and prognostic factor analysis for keratolimbal allografts.

Purpose: To evaluate the long-term results of keratolimbal allograft (KLAL) and elucidate the prognostic factors of KLAL survival.

Methods: Twenty-four eyes of 22 patients underwent KLAL one or more times, and were followed up more than 1 year postoperatively. Their medical records were reviewed.

Interleukin-17 in various ocular surface inflammatory diseases.

Recently, the association of Th-17 cells or IL-17 with ocular inflammatory diseases such as uveitis, scleritis and dry eye syndrome was discovered. We assessed whether interleukin (IL)-17 was present in the tears of various ocular surface inflammatory diseases and the tear IL-17 concentrations were clinically correlated with various ocular surface inflammatory diseases. We measured concentrations of IL-17 in tears of normal subjects (n = 28) and patients (n = 141) with meibomian gland dysfunction (MGD), dry eye syndrome (DES), Sjögren syndrome (SS), Stevens-Johnson syndrome (SJS), graft-versus-host disease (GVHD), filamentary keratitis, and autoimmune keratitis associated with rheumatoid arthritis or systemic lupus erythematosus.

Intraocular lens power calculation using IOLMaster and various formulas in short eyes.

Purpose: To evaluate the predictability of intraocular lens (IOL) power calculations using the IOLMaster and four different IOL power calculation formulas (Haigis, Hoffer Q, SRK II, and SRK/T) for cataract surgery in eyes with a short axial length (AL).

Methods: The present study was a retrospective comparative analysis which included 25 eyes with an AL shorter than 22.0 mm that underwent uneventful phacoemulsification with IOL implantation from July 2007 to December 2008 at Seoul National University Boramae Hospital.

Measurement of distance objective visual acuity with the computerized optokinetic nystagmus test in patients with ocular diseases.

Backgrounds: To evaluate the efficacy of a computerized optokinetic nystagmus (OKN) test for determination of objective visual acuity (VA) at distance in patients with various ocular diseases.

Methods: This is a prospective, non-interventional study that included 85 eyes of 71 patients with one or more ocular pathologies. Study patients were classified into group C (39 eyes of 30 patients with central visual damage), group P (24 eyes of 20 patients with peripheral visual defect) and group M (22 eyes of 21 patients with media opacity).

A case of retained graphite anterior chamber foreign body masquerading as stromal keratitis.

We report a case of a retained graphite anterior chamber foreign body that was masquerading as stromal keratitis. A 28-year-old male visited with complaints of visual disturbance and hyperemia in his right eye for four weeks. On initial examination, he presented with a stromal edema involving the inferior half of the cornea, epithelial microcysts, and moderate chamber inflammation.

Investigating the relationship between serum interleukin-17 levels and systemic immune-mediated disease in patients with dry eye syndrome.

Purpose: To investigate the association between dry eye syndrome (DE) and serum levels of interleukin (IL)-17 in patients with systemic immune-mediated diseases.

Methods: IL-17 and IL-23 levels were measured in the sera of patients whose tear production was <5 mm on the Schirmer test. Subjects included patients with chronic graft-versus-host disease (GVHD), rheumatoid arthritis (RA), Sjogren's syndrome (SS), systemic lupus erythematosus (SLE), and no systemic disease.

Secondary intraocular lens implantation in longstanding unilateral aphakia.

Purpose: To investigate the effect of secondary intraocular lens (IOL) implantation on binocular vision in patients with unilateral aphakia uncorrected consecutively for 3 years or more.

Methods: This study included nine patients who underwent secondary IOL implantation, but had remained in a unilateral aphakic state, without being corrected, for at least 3 consecutive years at the time of the secondary IOL implant. They also had a postoperative best-corrected visual acuity of better than 20/40 in both eyes.

The comparison between torsional and conventional mode phacoemulsification in moderate and hard cataracts.

Purpose: To compare the intraoperative performances and postoperative outcomes of cataract surgery performed with longitudinal phacoemulsification and torsional phacoemulsification in moderate and hard cataracts.

Methods: Of 85 patients who had senile cataracts, 102 eyes were operated on using the Infiniti Vision System. Preoperative examinations (slit lamp examination, mean central corneal thickness, and central endothelial cell counts) were performed for each patient.

Clinical features, predisposing factors, and treatment outcomes of scleritis in the Korean population.

Purpose: To evaluate the clinical features, associated factors, and treatment outcomes of scleritis in the Korean population.

Methods: Medical records were retrospectively reviewed for 94 eyes of 76 patients with scleritis. Clinical features of scleritis, including systemic disease, presence of microorganisms, serologic markers, history of previous ocular surgery, and use of immunosuppressants were investigated and compared amongst the subtypes of scleritis.

The antigenicity of ex vivo cultivated human corneal limbal epithelial and stromal cells: temporal changes in vitro.

Purpose: To investigate the effect of ex vivo culture on the expression of human leukocyte antigen (HLA) in human corneal limbal epithelial cells (LECs), and to evaluate the expression of HLA and costimulatory molecules on human corneal limbal stromal cells (LSCs).

Methods: The expression of HLA-ABC and HLA-DR were evaluated using flow cytometry on cultured human LECs and LSCs after serial passage and compared with that on freshly isolated cells. Additionally, the expression of costimulatory molecules CD80, CD86, CD40, and immunoregulatory molecule HLA-G were investigated on LSCs with or without an addition of interferon (IFN) γ (250 U/mL, 4 days).

Effects of multicurve RGP contact lens use on topographic changes in keratoconus.

Purpose: To evaluate the effects of wearing rigid gas permeable (RGP) contact lenses on the topographic changes in keratoconus.

Methods: Seventy-seven keratoconic eyes that wore multicurve RGP contact lenses and 30 keratoconic eyes that wore no contact lenses were retrospectively analyzed. The mean follow-ups were 22.