The study of neuroprotective effect of ferulic acid based on cell metabolomics.

Ferulic acid (FA), a naturally derived phenolic compound, has antioxidant and antidepressant-like effects. It is still a challenge to study its mechanism due to the complexity of the pathophysiology of depression. In this study, ultra-high performance liquid chromatography coupled with quadrupole time-of-flight mass spectrometry (UPLC-QTOF-MS) was used to perform metabolomics studies based on biochemical changes in differentiated rat pheochromocytoma (PC12) cells treated with corticosterone-induced neurological damage after FA treatment.

[Water use strategy of Tamarix chinensis during a drought year in the coastal wetlands of the Yellow River Delta, China].

Tamarix chinensis, the dominant species of plant communities in the coastal wetlands of the Yellow River Delta, was selected to study the water use strategy of coastal plants at different habitats during a drought year. The ΔO values for xylem water of T. chinensis were analyzed.

Parental health and social support in the first trimester of pregnancy and the risk of oral clefts: a questionnaire-based, case-control study.

Background: Nonsyndromic oral clefts are complex in cause and have multiple genetic and environmental risk factors. This retrospective, questionnaire-based, case-control study investigated the relationship between oral clefts and parental mental and physical health and social support.

Methods: Three hundred forty-seven parents of children with nonsyndromic oral clefts and 420 controls were included.

[Quality level assessment of lowly efficient Tamarix chinensis secondary shrubs in Laizhou Bay of Yellow River Delta].

Taking the Tamarix chinensis secondary shrubs in Laizhou Bay of Yellow River Delta as test objects, and by using synthetic factor method, this paper studied the main factors causing the lowly efficiency of T. chinensis secondary shrubs as well as the main parameters for the classification of lowly efficient T. chinensis secondary shrubs.

Isolation and Characterzation of p160.2, a Signal Transducing Protein Downstream of Jak3.

Nonreceptor tyrosine kinase Jak3, which binds to intracellular domain of interleukin-2 receptor gamma subunit (IL-2Rgamma), plays an important role in IL-2 function. To find downstream signal transducer of Jak3, the N-terminal region JH3-JH7 of Jak3 was used as a baitg to screen a cDNA library by using the yeast two-hybrid system. One real true clone was obtained out of 10(5) cotransformants.

Interaction between Jak3 and Nucleosome Assembly Protein 1.

Tyrosine kinase Jak3 plays a critical role in the interleukin 2 IL-2 signaling because it not only participates the Jak-Stat pathway, but also interacts with unidentified signal transducers and regulates expression of some oncogenes such as c-fos and c-myc. Abundant evidence demonstrated that phosphorylated tyrosine was necessary for the interaction between two proteins. Therefore, in order to clarify the role of Jak3 in IL-2 signal transduction, the tyrosine-phosphorylation-involved yeast two-hybrid system was constructed and the N-terminal region JH3-JH7 of Jak3 was used as a bait to screen a peripheral blood cDNA library.