Omnidirectional Bending Sensor with Bianisotropic Structure for Wearable Electronics.

Bending sensors are critical to the advancement of wearable electronics and can be applied in the dynamic monitoring of flexible object morphology. However, current bending sensors are constrained by sensing range and precision, especially in full-range detection. The maximum sensing range of existing flexible bending sensors is 0-240°.

M2-like Macrophages-derived CCL17 Promotes Esophageal Squamous Cell Carcinoma Metastasis and Stemness via Activating CCR4-mediated ERK/PD-L1 Pathway.

Background And Objective: High morbidity, high mortality and poor prognosis of esophageal squamous cell carcinoma (ESCC) highlights the urgent need for novel therapeutic strategies against ESCC. The current study addresses the precise role of M2-like macrophages-derived CCL17 in ESCC progression and to thoroughly elucidate the intrinsic molecular mechanisms.

Methods: In this work, for functional experiments, Eca109 cells cultivated in M2-CM were treated with anti-IgG (50 μg/ml) or anti-CCL17 (50 μg/ml) to expound the tumorpromoting effects of M2-like macrophage-derived CCL17 in ESCC.

Integrated Genome-Wide Analysis of DNA Methylation and Gene Expression in the Hippocampi of 5xFAD Alzheimer's Disease Mouse Model.

Background: DNA methylation forms 5-methylcytosine and its regulation in the hippocampus is critical for learning and memory. Indeed, dysregulation of DNA methylation is associated with neurological diseases. Alzheimer's disease (AD) is the predominant of dementia and a neurodegenerative disorder.

Lessons learned from follow up of spleen-preserving distal pancreatectomy with artery saving and vein sacrificing.

Background: The Warshaw method as a technique for spleen-preserving distal pancreatectomy (SPDP) carries the risk of splenic infarction following splenic artery ligation. This study introduces a modified Warshaw method, which preserves the splenic artery while sacrificing the splenic vein, and compares its outcomes with the traditional Warshaw method.

Methods: According to the bleeding status during vessel dissection, either the Warshaw method (group W) or the modified Warshaw method (group MW) was used.

Insights into the performance of PREDICT tool in a large Mainland Chinese breast cancer cohort: a comparative analysis of versions 3.0 and 2.2.

Background: PREDICT is a web-based tool for forecasting breast cancer outcomes. PREDICT version 3.0 was recently released.

Microplastics weaken the digestion and absorption functions in the golden pompano (Trachinotus blochii) by affecting the intestinal structure, bacteria and metabolites.

Microplastics are difficult to degrade and widespread environmental pollutants. Coastal areas are hardest hit of microplastic pollution as they receive significant amounts of microplastics discharged from inland sources. Golden pompano (Trachinotus blochii) is a high commercial valuable marine aquaculture fish species, most of the golden pompano are raised in coastal areas, which means they are at significant risk of exposure to microplastics.

Expression of genes related to gonadal development and construction of gonadal DNA methylation maps of Trachinotus blochii under hypoxia.

Chronic hypoxia can affect the growth and metabolism of fish and potentially impact gonadal development through epigenetic regulation. Trachinotus blochii (Golden pompano) is widely cultured near the coast and is sensitive to low oxygen conditions. We found that hypoxia and reoxygenation processes acted on multiple targets on the HPG axis, leading to endocrine disorders.

Exosomal NAT10 from esophageal squamous cell carcinoma cells modulates macrophage lipid metabolism and polarization through ac4C modification of FASN.

N-acetyltransferase 10 (NAT10) is acknowledged as a tumor promoter in various cancers due to its role as a regulator of acetylation modification. Tumor-associated macrophages (TAMs) play a pivotal role in the tumor microenvironment (TME). However, the intercellular communication between esophageal squamous cell carcinoma (ESCC) cells and TAMs involving NAT10 remains poorly understood.

The Usefulness of High-Magnification Loupe for Reducing Biliary Complications After Liver Transplantation.

Background: Despite advances in surgical techniques, biliary complications are still considered to be a technical "Achilles' heel" of liver transplantation (LT). The purpose of this study was to evaluate the effect of loupe magnification in reducing biliary complications after LT.

Materials And Methods: From April 2017 to February 2022, LT was performed on 307 patients in our center.

Doping proanthocyanidins into gel/zirconium hybrid hydrogel to reshape the microenvironment of diabetic wounds for healing acceleration.

Infection and chronic inflammation caused by oxidative stress are major challenges in chronic wound healing. Preparing a simple, efficient hydrogel with reactive oxygen-scavenging properties for chronic wound repair is a promising strategy. Herein, we report an injectable, self-repairing hydrogel with antioxidant and antibacterial properties that can be used to regenerate diabetic wounds.

Integrated Analysis of DNA Methylation and Gene Expression Profiles in a Rat Model of Osteoarthritis.

Osteoarthritis (OA) is common and affected by several factors, such as age, weight, sex, and genetics. The pathogenesis of OA remains unclear. Therefore, using a rat model of monosodium iodoacetate (MIA)-induced OA, we examined genomic-wide DNA methylation using methyl-seq and characterized the transcriptome using RNA-seq in the articular cartilage tissue from a negative control (NC) and MIA-induced rats.

ASCC3 promotes the immunosuppression and progression of non-small cell lung cancer by impairing the type I interferon response via CAND1-mediated ubiquitination inhibition of STAT3.

Background: Activating signal cointegrator 3 (ASCC3) has been identified as an oncogenic factor that impairs host immune defense. However, the underlying mechanisms of carcinogenesis and its impact on the antitumor immune response remain unclear. In this study, we aimed to investigate the molecular mechanisms of ASCC3 in the progression of non-small cell lung cancer (NSCLC).

Chondroprotective effects of larvae as an edible insect on osteoarthritis in mice.

Osteoarthritis (OA) is a common chronic joint inflammatory disease characterized by progressive destruction of the articular cartilage, bone remodeling, and excessive chronic pain. Most therapeutic approaches do not rescue the progression of OA effectively or provide relief of symptoms. larva (PBSL), which is attracting attention, is an edible insect with very high nutritional value and herbal medicine for the treatment of blood stasis, hepatic disease, and various inflammatory diseases.

Three-Directional Spacer-Knitted Piezoresistant Strain and Pressure Sensor for Electronic Integration and On-Body Applications.

The advancement of smart textiles has resulted in significant development in wearable textile sensors and offers novel interfaces to sense physical movements in daily life. Knitting, as a traditional textile fabrication method, is being used in promising ways to realize fully seamless fabrication and unobtrusive sensing in wearable textile applications. However, current flat-knitted sensors can sense strain only in the horizontal plane.

Self-supervised enhanced thyroid nodule detection in ultrasound examination video sequences with multi-perspective evaluation.

Ultrasound is the most commonly used examination for the detection and identification of thyroid nodules. Since manual detection is time-consuming and subjective, attempts to introduce machine learning into this process are ongoing. However, the performance of these methods is limited by the low signal-to-noise ratio and tissue contrast of ultrasound images.

Comparative Morphology of Island and Inland Agastache rugosa and Their Gastroprotective Effects in EtOH/HCl-Induced Gastric Mucosal Gastritis.

Kuntze (Lamiaceae; Labiatae), a medicinal and functional herb used to treat gastrointestinal diseases, grows well both on islands and inland areas in South Korea. Thus, we aimed to reveal the morphological and micromorphological differences between grown on island and inland areas and their pharmacological effects on gastritis in an animal model by combining morphological and mass spectrophotometric analyses. Morphological analysis showed that island had slightly smaller plants and leaves than inland plants; however, the density of all types of trichomes on the leaves, petioles, and stems of island was significantly higher than that of inland plants.

Trace Tungsten Microalloying PtCuCo Medium Entropy Alloys: Substructure Reconstruction-Triggered High-Performance for PEMFC.

Refractory metals (W, Nb, or Mo) microalloying Pt-based alloys with unprecedented performance may serve as advanced electrocatalysts for proton exchange membrane fuel cells (PEMFCs). These alloys are endowed with unique stabilizing substructures or lattice defects through the microalloying effect. Herein, trace W microalloying PtCuCo medium entropy alloys (W-PtCuCo) are reported via a stepwise synthesis strategy, starting with home-made Cu nanowires as sacrificial templates by anhydrous solid-phase milling route, and then followed by galvanic replacement-assisted solvothermal in ethylene glycol (EG).

Deep Ensemble Learning for Retinal Image Classification.

Purpose: Vision impairment affects 2.2 billion people worldwide, half of which is preventable with early detection and treatment. Currently, automatic screening of ocular pathologies using convolutional neural networks (CNNs) on retinal fundus photographs is limited to a few pathologies.

Butterfly Effect of Electron Donor from Monoatomic Cobalt in Few-Atom Platinum Clusters: Boosting Electrocatalysis.

Few-atom metal clusters feature an extremely large surface area and abundant active sites, which are particularly important for electrocatalysis. Herein, we report a monoatomic cobalt tailoring strategy to boost the performance of platinum clusters (ca. <1 nm) via hetero-charge-trapping chemistry by ultraviolet light reducing Pt-based anions anchored on target Co cations.

Self-Strained Platinum Clusters with Finite Size: High-Performance Catalysts with CO Tolerance for PEMFCs.

Strained platinum-based materials with high performance have been regarded as the most promising electrocatalysts for proton exchange membrane fuel cells (PEMFCs) recently. Herein, self-strained platinum clusters with finite size (about 1 nm) are prepared by a combining liquid- and solid-phase UV irradiation cycle strategy. It started with a fresh HPtCl solution irradiated by UV light and then mixed with a graphitized carbon, followed by the dried mixture being subjected to UV light to generate monodispersed Pt clusters on the carbon surface.

Elevated circASCC3 limits antitumor immunity by sponging miR-432-5p to upregulate C5a in non-small cell lung cancer.

Although anti-programmed cell death 1 (PD1) treatment has become a first-line therapy for advanced non-small cell lung cancer (NSCLC), most NSCLC patients are refractory to anti-PD1. Here, we aimed to investigate the mechanism of dysregulated circular RNAs (circRNAs) related to anti-PD1 resistance in NSCLC. The expression of circASCC3 (hsa_circ_0077,495) in NSCLC tissues and cell lines was evaluated by fluorescence in situ hybridization and quantitative reverse transcription-polymerase chain reaction.

MXene-Based Textile Sensors for Wearable Applications.

Textile-based sensors in the form of a wearable computing device that can be attached to or worn on the human body not only can transmit information but also can be used as a smart sensing device to access the mobile internet. These sensors represent a potential platform for the next generation of human-computer interfaces. The continuous emergence of new conductive materials is one of the driving forces for the development of textile sensors.