Osteomyelitis Caused by Citrobacter koseri in a Young Immunocompetent Man.

is a non-sporulating, motile, gram-negative, facultative anaerobic bacteria found in various environmental sources, including the human intestine. It is considered an opportunistic infection as it typically causes infection in newborns, elderly, and immunocompromised patients. Common sites of infection are the urinary tract, gastrointestinal system, and respiratory tract in immunocompromised adults, as well as the bloodstream and meninges in newborns.

Parenteral treprostinil induction for rapid attainment of therapeutic doses of oral treprostinil.

Rationale: Oral treprostinil slows disease progression and improves exercise capacity in pulmonary arterial hypertension; however, titration can be prolonged. Published data suggests prostacyclin-naïve patients achieve total daily oral treprostinil doses of about 6 mg by Week 16, while those on prior parenteral treprostinil reach higher doses at the same timepoint.

Objectives: EXPEDITE (NCT03497689), a single-arm, multicenter study, assessed the efficacy of rapid parenteral treprostinil induction to quickly reach higher doses of oral treprostinil for the treatment of pulmonary arterial hypertension.

Implementing the EXPEDITE parenteral induction protocol: Rapid parenteral treprostinil titration and transition to oral treprostinil.

Treprostinil is a prostacyclin analogue that targets multiple cellular receptors to treat pulmonary arterial hypertension (PAH). In certain scenarios, patients may require aggressive treprostinil titration. Several studies have demonstrated that higher doses of treprostinil lead to greater clinical benefit.

Oxygen uptake response to stroke rate manipulation in freestyle swimming.

Unlabelled: During gait, humans choose a combination of step length and step rate that minimizes V˙O2. However, little work has been reported on the existence of such optimization in swimming.

Purpose: The purpose of this study was to examine the manipulation of stroke rate on V˙O2 in submaximal, constant speed freestyle swimming.

Topics and cases for online education in engineering.

When considering offering online education for engineering ethics instruction, making choices necessary for the effective development and delivery of an engineering ethics curriculum is an important first step. Selecting the topics and types of cases for the most effective ethics education of engineering students is a vital step in preparing an effective program. Examples are presented for topics which are considered good candidates for online presentation, and the adaptability of these topics for web-based instruction is discussed.

Effect of sampling strategy on measures of VO2peak obtained using commercial breath-by-breath systems.

The purpose of this study was to determine the effect of sampling strategy (i.e., number of breaths) on measured peak rate of oxygen uptake ( VO(2peak)) elicited by a range of severe intensity exercise bouts.

The relationship between power and the time to achieve .VO(2max).

Purpose: The severe exercise intensity domain may be defined as that range of work rates over which .VO(2max) can be elicited during constant-load exercise. The purpose of this study was to help characterize the .