Publications by authors named "Jimmy F Goncalves"
Environmental conditions can modulate innate behaviours. Although male Caenorhabditis elegans copulation can be perturbed in the presence of stress, the mechanisms underlying its decision to sustain copulation are unclear. Here we describe a mating interference assay, which quantifies the persistence of male C.
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- Temporal development in the nematode C. elegans is typically synchronized, but losing the nicotinamidase enzyme PNC-1 disrupts this synchronization, slowing reproductive development.
- Using advanced mass spectrometry, researchers found that pnc-1 mutants struggle to recycle nicotinamide back to NAD(+), leading to decreased NAD(+) levels that hinder normal gonad maturation.
- Despite a deficiency in NAD(+), mitochondrial function remains stable, suggesting that metabolic adjustments that support mitochondria are at odds with the high cell division demands required for reproductive development.