Publications by authors named "Jimmie L Valentine"

Background: Hypothesis: School reopening had a significant impact on COVID-19 infection rates across USA states.

Methods: Eight states with fully reopened public schools were studied. States who did not previously have stay-at-home orders for a minimum of 30 days were excluded from the study so that increases in infection rates would be solely due to the economies of reopening.

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Background: Protests ignited by the George Floyd incident were examined for any significant impact on COVID-19 infection rates in select US cities.

Methods: Eight US cities were studied in which protestors in the tens of thousands were reported. Only cities that reside in states whose stay-at-home orders had been rescinded or expired for a minimum of 30 days were included in the sample to account for impact of growth rates solely due to economies reopening.

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Article Synopsis
  • The study investigates the effectiveness of nordihydroguaiaretic acid (NDGA) in reducing airway resistance in guinea pigs sensitized to ovalbumin (OA), showing its potential as a therapeutic agent.
  • NDGA was administered via aerosol and intravenous methods, both resulting in a decrease in airway resistance and intra-tracheal pressure following OA exposure.
  • The mechanism of NDGA's action is thought to involve the inhibition of 5-lipoxygenase, leading to reduced synthesis of leukotrienes, which are compounds that can exacerbate airway inflammation and constriction.
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Estimates of the prevalence of drug usage during pregnancy vary by region and survey tool used. Clinicians providing care to newborns should be equipped to recognize a newborn who has been exposed to illicit drugs during pregnancy by the effects the exposure might cause at the time of delivery and/or by drug testing of the newborn. The purpose of this paper is to provide an overview of the literature and assess the clinical role of drug testing in the newborn.

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This study was designed to examine the potential structure-activity relationship between carboxylic acids, histone acetylation and T cell cycle blockade. Toward this goal a series of structural homologues of the short-chain carboxylic acid n-butyrate were studied for their ability to block the IL-2-stimulated proliferation of cloned CD4+ T cells. The carboxylic acids were also tested for their ability to inhibit histone deacetylation.

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