Publications by authors named "Jimmie Bullock"
Article Synopsis
- Serology testing is vital for assessing the effectiveness of COVID-19 vaccines and detecting past infections by measuring antibodies against SARS-CoV-2.
- This study validated four laboratory-developed serology tests for antibodies (IgG and IgM) against Spike and Nucleocapsid proteins, ensuring they met strict Clinical and Laboratory Standards Institute (CLSI) guidelines for reliability.
- Results showed good linearity and precision across the tests, demonstrating their validity for identifying levels of antibodies, which is crucial for ongoing COVID-19 research and management.
Article Synopsis
- SARS-CoV-2 serology is important for assessing COVID-19 vaccine effectiveness and immune response, but factors like tube type and anticoagulant can affect results.
- The study found no significant differences in antibody levels based on tube type; however, tubes with anticoagulants sodium citrate and ACD showed lower antibody concentrations, which were mostly adjusted after considering dilution factors.
- There were noticeable differences in IgG avidity between plasma and serum, suggesting that plasma treated with anticoagulant cannot be considered interchangeable with serum for certain assays, warranting further exploration.
Article Synopsis
- SARS-CoV-2 vaccination leads to changes in antibody levels and characteristics, which can influence protection against infection.
- After the initial vaccine series, IgG levels decrease over time while antibody avidity (binding strength) increases; however, this trend is reversed after a third booster dose, which boosts both IgG levels and avidity.
- Comparison between the two mRNA vaccines shows that one (BNT162b2) results in higher antibody avidity than the other (mRNA-1273) six months after the third dose.
Article Synopsis
- This study compares the immune responses of two mRNA vaccines (mRNA-1273 and BNT162b2) against SARS-CoV-2 to natural infection by measuring anti-Spike antibody levels and avidity in serum samples from different age groups.
- Results showed that both vaccines produced higher antibody levels and avidity than natural infection, with mRNA-1273 demonstrating superior antibody levels four months post-vaccination.
- Additionally, mRNA-1273 induced greater avidity than BNT162b2 at one month, though this was only significantly maintained in the younger age group by four months.
In this study, 9-anthraldehyde-N(4)-methylthiosemicarbazone (MeATSC) 1 and [Co(phen)(OCO)]Cl·6HO 2 (where phen = 1,10-phenanthroline) were synthesized. [Co(phen)(OCO)]Cl·6HO 2 was used to produce anhydrous [Co(phen)(HO)](NO)3. Subsequently, anhydrous [Co(phen)(HO)](NO)3 was reacted with MeATSC 1 to produce [Co(phen)(MeATSC)](NO)·1.
View Article and Find Full Text PDFMany dental procedures allow for implant placement in partially or totally edentulous patients. Despite the availability of various implant and abutment types on the market, it often becomes quite challenging to achieve the biological and esthetic goals in a patient who has ridge deficiencies. Problems arise from the lack of adequate bone quality and quantity.
View Article and Find Full Text PDFBackground: Nanotechnology has provided significant benefits to photodynamic therapy (PDT), which has revolutionized treatments of several diseases. The success of this versatile technique is governed by the sequential in situ generation of reactive oxygen species, after a suitable photosensitizer has been irradiated by a defined wavelength of light. While PDT provides a minimally-invasive and convenient method for the treatment of several afflictions, the efficiency of this therapeutic strategy still has potential for improvements.
View Article and Find Full Text PDF