Publications by authors named "Jimit J Doshi"
Brain Magnetic Resonance Imaging Findings in Children and Young Adults With CKD.
Am J Kidney Dis
September 2018
Background: The neuroanatomic basis for cognitive impairment in chronic kidney disease (CKD) is incompletely characterized. We performed advanced quantitative structural magnetic resonance imaging (MRI) to determine whether CKD affects brain structure and whether poorer neurocognitive performance in CKD is associated with structural brain differences.
Study Design: Cross-sectional.
Background: Chronic kidney disease is strongly linked to neurocognitive deficits in adults and children, but the pathophysiologic processes leading to these deficits remain poorly understood. The NiCK study (Neurocognitive Assessment and Magnetic Resonance Imaging Analysis of Children and Young Adults with Chronic Kidney Disease) seeks to address critical gaps in our understanding of the biological basis for neurologic abnormalities in chronic kidney disease. In this report, we describe the objectives, design, and methods of the NiCK study.
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- CKD (chronic kidney disease) is associated with cognitive deficits and emotional disorders, as supported by various studies focusing on neuroimaging in both children and adults.
- A systematic review was conducted on studies published from 1975 to 2012, finding significant trends such as brain atrophy, vascular issues, and similarities in brain blood flow patterns between CKD patients and those with affective disorders.
- The research emphasizes the role of neuroimaging in understanding how CKD affects brain structure and function over a person's lifetime, suggesting potential benefits for early detection and intervention strategies.