Downregulation of Wnt3 Suppresses Colorectal Cancer Development Through Inhibiting Cell Proliferation and Migration.

The aberrant expression of Wnt3 has linked to several types of human malignancies. However, it is not known for its role in tumorigenesis of colorectal cancer (CRC). Herein, we show that Wnt3 is upregulated in human CRC tissues and is essential for the CRC progression.

Knockdown of ZFPL1 results in increased autophagy and autophagy‑related cell death in NCI‑N87 and BGC‑823 human gastric carcinoma cell lines.

Macroautophagy, which will hereafter be referred to as autophagy, is an evolutionarily conserved process, during which cells recycle and remove damaged organelles and proteins in response to cellular stress. However, the mechanisms underlying the regulation of autophagy remain to be fully elucidated. The present study demonstrated that knockdown of zinc finger protein like 1 (ZFPL1) induces autophagy and increases autophagic cell death in NCI‑N87 and BGC‑823 human gastric carcinoma cell lines.

Correlation Between CASC8, SMAD7 Polymorphisms and the Susceptibility to Colorectal Cancer: An Updated Meta-Analysis Based on GWAS Results.

Genome-wide association studies (GWASs) and a number of case-control studies have suggested that several single nucleotide polymorphisms (SNPs), rs7837328, rs7014346, rs6983267, rs10505477 on CASC8 gene and rs4939827, rs4464148, rs12953717 on SMAD7 gene are significantly correlated with the susceptibility to colorectal cancer (CRC). For the sake of clarifying the association, a meta-analysis was conducted and population heterogeneity was considered in the study.A total of 34 articles including 90 studies (168,471 cases and 163,223 controls) that evaluated the relationship between the CASC8, SMAD7 genes and the risk of CRC under the allelic model were reviewed.

[Experiences of scarless laparoscopic radical resection of rectal cancer].

Objective: To explore the feasibility and safety of scarless laparoscopic radical resection of rectal cancer.

Methods: Clinical data of 26 patients who underwent scarless laparoscopic radical resection of rectal cancer from January 2011 to June 2013 were retrospectively analyzed. Lymph node dissection and transection of proximal and distal colon were performed in the conventional manner of total mesorectal excision (TME).

[The extraction and effects on mouse lymphocyte proliferation of immunoregulation components from Lysimachia hemsleyana].

Objective: To study the effects of extracted fractions from the whole plants of Lysimachia hemsleyana Maxim on the proliferation ability of lymphocytes in mice in vitro.

Methods: We extracted the components by using of ethanol, ether from petroleum, chloroform, ethyl acetate and n-butanol, successively then study them on the proliferation of lymphocytes in mice.

Results: The n-butanol fraction obviously inhibited the proliferation of spleen lymphocytes induced by LPS, bilaterally regulated the T lymphocyte proliferation induced by ConA.

Prevalence of rheumatic symptoms, rheumatoid arthritis, ankylosing spondylitis, and gout in Shanghai, China: a COPCORD study.

Objective: To carry out a cross-sectional survey on prevalence of musculoskeletal symptoms, rheumatoid arthritis (RA), ankylosing spondylitis (AS), and gout.

Methods: In Shanghai, 4 communities comprising 7603 inhabitants over 15 years of age in an urban population were randomly selected from 13 communities. Interviews were conducted from September 1997 to March 1998 by trained physicians using the COPCORD Core Questionnaire.

[The effects of n-butanol fraction of Lysimachia hemsleyana on the activities of lymphocytes in mice].

Objective: To study the effects of n-butanol fraction from the whole plants (Lysimachia hemsleyana) on the phagocytic activities of the peritoneal macrophage, production of interleukin-2.

Methods: We extracted the components with ethanol, acetic ether, n-butanol and chloroform, then studied the n-butanol fraction on the phagocytic activities of the peritoneal macrophage, production of interleukin-2 (IL-2) from splenocytes induced by ConA in mice in vitro.

Results: n-Butanol fraction of an ethanol extract of air-dried herbs bilaterally regulated the IL-2 production from splenocytes induced by ConA, and enhanced the phagocytic activities of activated mouse peritoneal macrophages.

[Clinical study on effect of Agkistrodon antithrombogenase in auxiliary treatment of rheumatoid arthritis].

Objective: To explore the clinical effect of Agkistrodon antithrombogenase (AAT) in the treatment of rheumatoid arthritis (RA) and its possible mechanism.

Methods: Besides the conventional non-steroid anti-inflammatory agents and disease-modifying anti-rheumatic drug, patients were treated supplementally with intravenous injection of AAT. The intracutaneous test showed allergic to AAT patients were treated with Salvia injection and taken as control group.