Therapeutic effect and mechanism of danshensu on coronary heart disease using liquid chromatography combined with mass spectrometry metabolomics.

Metabolomics can discover the biomarkers and metabolic pathways, provides the possibility for insights into the pharmacological action and mechanism of natural products. The therapeutic effect and mechanism of danshensu (DSS) on total metabolic pathways has not been well investigated. The aim of this study was to explore the disturbed endogenous biomarkers and metabolic pathways reflecting the pharmacological activity of DSS, and mechanism of action of DSS using comprehensive metabolome analysis based on high-throughput metabolomics technology combined with ultra-high performance liquid chromatography (UPLC) coupled with quadrupole tandem time-of-flight mass spectrometry (Q-TOF-MS) and pattern recognition method.

Logic Design and Power Optimization of Floating-Point Multipliers.

Under IEEE-754 standard, for the current situation of excessive time and power consumption of multiplication operations in single-precision floating-point operations, the expanded boothwallace algorithm is used, and the partial product caused by booth coding is rounded and predicted with the symbolic expansion idea, and the partial product caused by single-precision floating-point multiplication and the accumulation of partial products are optimized, and the flowing water is used to improve the throughput. Based on this, a series of verification and synthesis simulations are performed using the SMIC-7 nm standard cell process. It is verified that the new single-precision floating-point multiplier can achieve a smaller power share compared to the conventional single-precision floating-point multiplier.