Publications by authors named "Jiming Liu"

Article Synopsis
  • * The research indicates that this viral mimicry is driven by increased expression of specific genes with intronic inverted-repeat Alu elements, rather than the activation of retroelements seen in other therapies.
  • * Additionally, EZH2 inhibition enhances the expression of LINE-1 retrotransposons, which contributes to genomic instability and activates immune signaling pathways, but simultaneously blocking dsRNA and DNA sensing prevents the viral mimicry effect in these tumors.
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Grafting is a widely used technique for asexual plant reproduction, especially in agriculture and forestry. This procedure is used to shorten the seedling period, improve the structure of scion branches, and help plants adapt to difficult environments. Although grafting has numerous benefits, several obstacles remain to be overcome.

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Patients with osteoporosis face challenges such as decreased bone density, a sparse trabecular structure, weakened osteogenic ability, and impaired angiogenesis, leading to poor osseointegration and implant failure. Surface modification of implants with biologically active molecules possessing various functions is an effective strategy to improve osseointegration. In this study, we constructed a simple multifunctional coating interface that significantly improves osseointegration.

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  • - The study investigates the spread and genetic factors of the dengue virus (DENV-1) in Guangdong, China, from 1990 to 2019, highlighting its challenges to public health due to frequent imports causing outbreaks.
  • - Researchers analyzed 179 genomes from local dengue cases along with over 5,000 complete sequences, revealing complex transmission patterns and the presence of multiple dengue serotypes in the region, particularly Guangdong and Yunnan provinces.
  • - Key findings include the identification of 189 transmission clusters with specific clades responsible for major outbreaks and a periodicity of approximately 3 years, with Guangzhou emerging as a critical hub for DENV-1 transmission across China.
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  • Emerging infectious diseases require prompt detection and analysis to control their spread, but predicting key parameters like onset time and transmission dynamics early on is challenging.* -
  • We propose a Bayesian inference method that utilizes a stochastic SEIR model and the particle Markov chain Monte Carlo (PMCMC) technique to estimate essential epidemiological parameters effectively.* -
  • Our method was validated through case studies on COVID-19 in China, demonstrating its ability to accurately predict important metrics, making it a useful tool for investigating various infectious diseases beyond just COVID-19.*
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Background: Despite the increasing focus on strengthening One Health capacity building on global level, challenges remain in devising and implementing real-world interventions particularly in the Asia-Pacific region. Recognizing these gaps, the One Health Action Commission (OHAC) was established as an academic community for One Health action with an emphasis on research agenda setting to identify actions for highest impact.

Main Text: This viewpoint describes the agenda of, and motivation for, the recently formed OHAC.

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Exploring keystone taxa affecting microbial community stability and host function is crucial for understanding ecosystem functions. However, identifying keystone taxa from humongous microbial communities remains challenging. We collected 344 rhizosphere and bulk soil samples from the endangered plant C.

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Osseointegration is an important indicator of implant success. This process can be improved by coating modified bioactive molecules with multiple functions on the surface of implants. Herein, a simple multifunctional coating that could effectively improve osseointegration was prepared through layer-by-layer self-assembly of cationic amino acids and tannic acid (TA), a negatively charged molecule.

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Aims: Roots are key parts of plant material circulation and energy flow, creating two distinct niches for the plant microbiome, such as the rhizosphere and root endosphere, which interact to maintain plant growth and health. In this study, two niches of plant rhizosphere and root endosphere were selected to study the composition and differences of fungi communities in order to better understand how differences in the structure and function of plant fungi communities affect plant health.

Methods And Results: The community structure, diversity, and ecological function of fungi in the rhizosphere and root endosphere of Cinnamomum migao were studied using high-throughput sequencing techniques, traditional culture methods, and the FUNGuild database.

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Electrocatalysis has emerged as one of the most promising alternatives to conventional anthraquinone for preparing hydrogen peroxide (HO) with high energy consumption and pollution because of its simplicity, convenience, and environmental friendliness. However, the oxygen reduction reaction (ORR) generating HOviathe2e path is acompetitive path for 4eORR to generate HO. Therefore, it is crucial to identify an electrocatalyst with high selectivity and activity of 2eORR.

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For clinical studies with continuous outcomes, when the data are potentially skewed, researchers may choose to report the whole or part of the five-number summary (the sample median, the first and third quartiles, and the minimum and maximum values) rather than the sample mean and standard deviation. In the recent literature, it is often suggested to transform the five-number summary back to the sample mean and standard deviation, which can be subsequently used in a meta-analysis. However, if a study contains skewed data, this transformation and hence the conclusions from the meta-analysis are unreliable.

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  • - The study investigates the effects of soil properties and management on the bioavailability of heavy metals (Cd and Zn) in a rice-rape rotation cropping system in the Guizhou karst area, where Cd levels are high.
  • - Researchers conducted field experiments and laboratory analyses to assess how differing soil characteristics impact the bioaccumulation of these metals in rice and rape throughout various growth stages and soil depths.
  • - Findings show that soil properties like particle size, pH, and organic matter significantly influence the enrichment of Cd and Zn in crops, with Cd more readily accumulating in rice, while Zn is more common in rape, highlighting the need for strategies to manage metal pollution in agricultural settings.
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Drought greatly influences the growth and ecological stoichiometry of plants in arid and semi-arid regions such as karst areas, where () is an endemic tree species that is used as a bioenergy resource. Arbuscular mycorrhizal fungi (AMF) play a key role in nutrient uptake in the soil-plant continuum, increasing plant tolerance to drought. However, few studies have examined the contribution of AMF in improving the growth of seedlings and the soil nutrient stoichiometry under drought-stress conditions.

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Introduction: Rhizobacterial communities and their metabolites can affect plant growth, development, and stress resistance, as well as the biosynthesis and accumulation of bioactive compounds in medicinal plants. This relationship has been well-characterized in many medicinal herbs, although much less commonly in medicinal trees.

Methods: Here, we analyzed the composition and structure of rhizobacterial communities across nine growing regions in Yunnan, Guizhou and Guangxi, China, as well as differences in soil properties and fruit bioactive compounds.

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Background: The heterogeneity of COVID-19 spread dynamics is determined by complex spatiotemporal transmission patterns at a fine scale, especially in densely populated regions. In this study, we aim to discover such fine-scale transmission patterns via deep learning.

Methods: We introduce the notion of TransCode to characterize fine-scale spatiotemporal transmission patterns of COVID-19 caused by metapopulation mobility and contact behaviors.

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Malaria control can significantly benefit from a holistic and precise way of quantitatively measuring the transmission intensity, which needs to incorporate spatiotemporally varying risk factors. In this study, we conduct a systematic investigation to characterize malaria transmission intensity by taking a spatiotemporal network perspective, where nodes capture the local transmission intensities resulting from dominant vector species, the population density, and land cover, and edges describe the cross-region human mobility patterns. The inferred network enables us to accurately assess the transmission intensity over time and space from available empirical observations.

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Article Synopsis
  • Triterpenoid saponins are special compounds found in soapberry that are used in medicine and personal care products.
  • Scientists studied the role of miRNAs, which are tiny molecules that help control how saponins are made in soapberries, and found over 3000 different miRNAs.
  • They discovered specific miRNAs that influence saponin production and created networks showing how these miRNAs interact with other genes, helping to explain the process better.
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Changes in altitude can cause regional microclimate changes, leading to the spatial heterogeneity of environmental factors and soil bacteria. However, the internal driving process and mechanism remain unclear. Here, we selected Fanjingshan, a typical nature reserve in the subtropical region of south China with a clear altitudinal belt, to reveal the response mechanisms of microbial populations with altitude changes.

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Background: Dengue is the fastest spreading arboviral disease, posing great challenges on global public health. A reproduceable and comparable global genotyping framework for contextualizing spatiotemporal epidemiological data of dengue virus (DENV) is essential for research studies and collaborative surveillance.

Methods: Targeting DENV-1 spreading prominently in recent decades, by reconciling all qualified complete E gene sequences of 5003 DENV-1 strains with epidemiological information from 78 epidemic countries/areas ranging from 1944 to 2018, we established and characterized a unified global high-resolution genotyping framework using phylogenetics, population genetics, phylogeography, and phylodynamics.

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Subspace learning (SL) plays a key role in various learning tasks, especially those with a huge feature space. When processing multiple high-dimensional learning tasks simultaneously, it is of great importance to make use of the subspace extracted from some tasks to help learn others, so that the learning performance of all tasks can be enhanced together. To achieve this goal, it is crucial to answer the following question: How can the commonality among different learning tasks and, of equal importance, the individuality of each single learning task, be characterized and extracted from the given datasets, so as to benefit the subsequent learning, for example, classification? Existing multitask SL methods usually focused on the commonality among the given tasks, while neglecting the individuality of the learning tasks.

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To improve the utilization of raw materials, the fermentation of light-flavor Baijiu (LFB) will usually take two rounds of fermentation to the same batch of raw materials. The microorganisms involved in the fermented grains (FG) from these two fermentation rounds are the key to the quality formation of light-flavor style. Using Illumina MiSeq high-throughput sequencing and electronic-senses, it was found that the microbiota and flavor of FG for light-flavor Baijiu were mainly affected by fermentation rounds rather than depths, while the physicochemical factors were just the opposite.

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Complex network models are helpful to explain the evolution rules of network structures, and also are the foundations of understanding and controlling complex networks. The existing studies (e.g.

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The decomposition of litter plays an important role in the return of forest soil nutrients, as well as the growth and productivity of plants. With this study, we aimed to determine the impact of litter mulching on different tissues of , a rare Chinese endemic species. In particular, seeds and pericarp are easily overlooked components of litter.

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