Mast cell activation induced by tamoxifen citrate via MRGPRX2 plays a potential adverse role in breast cancer treatment.

Breast cancer is the most common malignant tumor endangering women's life and health. Tamoxifen citrate (TAM) is the first-line drug of adjuvant endocrine therapy for estrogen receptor-positive (ER) breast cancer patients. Some sporadic cases have described rare adverse reactions of TAM with potentially life-threatening dermatological manifestations, which were associated with skin allergy.

Toward Better and Healthier Air Quality: Global PM and O Pollution Status and Risk Assessment Based on the New WHO Air Quality Guidelines for 2021.

To reduce the high burden of disease caused by air pollution, the World Health Organization (WHO) released new Air Quality Guidelines (AQG) on September 22, 2021. In this study, the daily fine particulate matter (PM) and surface ozone (O) data of 618 cities around the world is collected from 2019 to 2022. Based on the new AQG, the number of attainment days for daily average concentrations of PM (≤ 15 µg m) and O (≤ 100 µg m) is approximately 10% and 90%, respectively.

Spatiotemporal patterns of surface ozone exposure inequality in China.

Rising surface ozone (O) levels in China are increasingly emphasizing the potential threats to public health, ecological balance, and economic sustainability. Using a 1 km × 1 km dataset of O concentrations, this research employs subpopulation demographic data combined with a population-weighted quality model. Its aim is to evaluate quantitatively the differences in O exposure among various subpopulations within China, both at a provincial and urban cluster level.

Spatial-temporal evolution patterns and drivers of PM chemical fraction concentrations in China over the past 20 years.

The quantitative assessment of the spatial and temporal variability and drivers of fine particulate matter (PM) fraction concentrations are important for pollution control and public health preservation in China. In this study, we investigated the spatial temporal variation of PM chemical component based on the PM chemical component datasets from 2000 to 2019 and revealed the driving forces of the differences in the spatial distribution using geodetector model (GD), multi-scale geographically weighted regression model (MGWR), and a two-step clustering approach. The results show that: the PM chemical fraction concentrations show a trend of first increasing (2000-2007) and then decreasing (2007-2019).

Black carbon pollution in China from 2001 to 2019: Patterns, trends, and drivers.

Based on a near real-time 10 km × 10 km resolution black carbon (BC) concentration dataset, this study investigated the spatial patterns, trend variations, and drivers of BC concentrations in China from 2001 to 2019 with spatial analysis, trend analysis, hotspot clustering, and multiscale geographically weighted regression (MGWR). The results indicate that Beijing-Tianjin-Hebei, the Chengdu-Chongqing agglomeration, Pearl River Delta, and East China Plain were the hotspot centers of BC concentration in China. From 2001 to 2019, the average rate of decline in BC concentrations across China was 0.

Domino effect of a natural cascade alpine lake system on the Third Pole.

Third Pole natural cascade alpine lakes (NCALs) are exceptionally sensitive to climate change, yet the underlying cryosphere-hydrological processes and associated societal impacts are largely unknown. Here, with a state-of-the-art cryosphere-hydrology-lake-dam model, we quantified the notable high-mountain Hoh-Xil NCALs basin (including Lakes Zonag, Kusai, Hedin Noel, and Yanhu, from upstream to downstream) formed by the Lake Zonag outburst in September 2011. We demonstrate that long-term increased precipitation and accelerated ice and snow melting as well as short-term heavy precipitation and earthquake events were responsible for the Lake Zonag outburst; while the permafrost degradation only had a marginal impact on the lake inflows but was crucial to lakeshore stability.

Modeling the effects of elevation and precipitation on Rice (Oryza sativa L.) production considering multiple planting methods and cultivars in Central China.

In this study, we investigated the effects of elevation and precipitation on rice (Oryza sativa L.) production using the Crop Environment Resource Synthesis (CERES)-Rice model in Hubei province, China. We divided our study area into four zones based on elevation and precipitation.

Evaluating and improving simulations of diurnal variation in land surface temperature with the Community Land Model for the Tibetan Plateau.

This study evaluated and improved the ability of the Community Land Model version 5.0 (CLM5.0) in simulating the diurnal land surface temperature (LST) cycle for the whole Tibetan Plateau (TP) by comparing it with Moderate Resolution Imaging Spectroradiometer satellite observations.

Effects of temperature frequency trends on projected japonica rice ( L.) yield and dry matter distribution with elevated carbon dioxide.

In this study, we investigated the effects of temperature frequency trends on the projected yield and dry matter distribution of japonica rice ( L.) with elevated carbon dioxide (CO) under future climate change scenarios in northwestern China. The Crop Environment Resource Synthesis (CERES)-Rice model was forced with the outputs from three general circulation models (GCMs) to project the rice growth and yield.