Publications by authors named "Jimin Kim"

Background: Hepatocellular carcinoma (HCC) stands as the sixth most prevalent cancer globally, presenting a substantial health challenge, particularly due to late-stage diagnoses that limit treatment effectiveness. Sorafenib, a multi-kinase inhibitor, is the primary chemotherapeutic agent for advanced HCC, but it only extends survival by 2-3 months. However, drug resistance remains a major clinical challenge, necessitating the exploration of new molecular mechanisms, including the role of microRNAs (miRNAs) in sorafenib resistance.

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While the importance of medical professionalism is widely recognized, strategies for incentivizing positive professionalism have not been formally reviewed. We reviewed available literature on interventions to promote professionalism in training and practice to identify common themes and differentiate extrinsic vs intrinsic motivators. Among 24 relevant articles identified for review, 4 programmatic themes emerged: recognition and rewards (extrinsic motivators), and review of performance and reflection (intrinsic motivators).

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Sensations of the internal state of the body play crucial roles in regulating the physiological processes and maintaining homeostasis of an organism. However, our understanding of how internal signals are sensed, processed, and integrated to generate appropriate biological responses remains limited. Here, we show that the C.

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Irradiation of the head and neck inevitably leads to decreased salivary gland function. It is postulated that radiation generates excessive reactive oxygen species (ROS) and reduces salivary gland function by ferroptosis, a new cell death mechanism; however, research in this area is currently lacking. In this study, we investigated the effects of amifostine and melatonin on acute salivary gland dysfunction and ferroptosis.

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  • Two novel genomic regions associated with resistance to the soybean disease Phytophthora root and stem rot were identified through genome-wide association analysis and linkage analysis, highlighting the complexity of disease resistance in soybean.* -
  • A significant new resistance locus was found on chromosome 8, which is notable because it had not been previously documented and contains multiple copies of a gene linked to disease resistance, alongside a known region on chromosome 3.* -
  • The research demonstrated that different combinations of resistance genes affect disease resistance, paving the way for enhanced soybean breeding strategies through marker-assisted selection to combat specific P. sojae isolates.*
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Nonalcoholic steatohepatitis (NASH) is a chronic liver disease associated with metabolic syndrome. Extracellular vesicles (EVs) are essential signaling mediators containing functional biomolecules. EVs are secreted from various cell types, and recent studies have shown that mesenchymal stem cell-derived EVs have therapeutic potential against immune and metabolic diseases.

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Background: Although there is consensus to use immunoglobulins and corticosteroids as first-line treatments for multisystem inflammatory syndrome in children (MIS-C), the effectiveness of biological immunomodulators in patients refractory to standard therapy remains unclear. We aimed to outline real-world data on biological immunomodulators.

Method: A literature search using Ovid-Medline, EMBASE, Cochrane CDSR, and KMBASE was conducted from September 2021 to August 2022; certainty of evidence was assessed via GRADE.

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Background: Previous research has shown that the use of renin-angiotensin system (RAS) blockers is linked to a lower prevalence of posttraumatic stress disorder (PTSD), but longitudinal studies are scarce. We aimed to estimate the association between the use of RAS blockers and the risk of PTSD among individuals taking antihypertensive medications.

Methods: This longitudinal study included participants aged 40-69 from the UK Biobank.

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  • Researchers conducted multiday experiments using the KIST chamber to study how ammonia (NH) and relative humidity (RH) influence the creation of secondary organic aerosols (SOA) from toluene and inorganic gases, revealing that humid conditions lead to significantly higher SOA formation.
  • The experiments showed that at 80% relative humidity, SOA production was 1.1 times greater in multiday initial injection tests compared to single-day tests and 1.6 times greater than in multiday cyclic injection tests, indicating that nighttime conditions contribute to increased SOA without needing additional emissions.
  • Findings suggest that reducing ammonia levels could help lower SOA and other particulate matter pollution, with greater humidity accelerating SOA formation, which is crucial
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This study aimed to measure the fracture strengths and hardness of final restorative milled and 3D-printed materials and evaluate the appropriate crown thickness for their clinical use for permanent prosthesis. One type of milled material (group M) and two types of 3D-printed materials (groups P1 and P2) were used. Their crown thickness was set to 0.

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Objective: To evaluate the comparative efficacy of two of the most commonly used second-line uterotonics-methylergonovine maleate and carboprost tromethamine.

Methods: We conducted a double-blind randomized trial at two large academic perinatal centers in patients undergoing nonemergency cesarean delivery with uterine atony refractory to oxytocin, as diagnosed by the operating obstetrician. The intervention included administration of a single dose of intramuscular methylergonovine or carboprost intraoperatively at diagnosis.

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Pancreatic ductal adenocarcinoma (PDAC) is a highly aggressive solid tumor. Recently, the uptake of extracellular citrate by the sodium-dependent citrate transporter (NaCT), encoded by , has been demonstrated to exert profound effects on cancer cell metabolism. However, research on the function of extracellular citrate in PDAC pathogenesis and the relationship between NaCT expression and the tumor metabolic microenvironment is limited.

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Comprehending early amyloidogenesis is essential for the development of effective therapeutic strategies. In tauopathies like Alzheimer's disease (AD), the abnormal accumulation of tau protein is initiated by pathological tau seeds. Mounting evidence implies that the microtubule binding domain, consisting of three to four repeats, plays a pivotal role in this process, yet the exact region driving the formation of pathogenic species needs to be further scrutinized.

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The emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants presents challenges in global efforts to transition from the pandemic to an endemic stage. The spike protein of the SARS-CoV-2 virus, which is pivotal for cell entry, exhibits significant mutations in its variants, potentially affecting infectivity and therapeutic efficacy. Recent findings indicate upregulation of the epidermal growth factor receptor (EGFR) pathway, a key target in cancer therapy, by the spike protein of SARS-CoV-2.

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Background: Androgenetic alopecia (AGA) is a common form of hair loss. Androgens, such as testosterone and dihydrotestosterone, are the main causes of AGA. Extracellular vesicles (EVs) derived from mesenchymal stem cells (MSCs) can reduce AGA.

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  • High defect density and poor crystallinity are significant challenges for creating efficient and stable Sn-based perovskite solar cells (PSCs).
  • The introduction of a new organic spacer, morpholinium iodide (MPI), enhances the structural stability of 2D/3D perovskite by increasing intermolecular interactions.
  • As a result, the MP-based PSCs achieved a power conversion efficiency of 12.04% and demonstrated improved stability, providing valuable insights for future PSC designs.
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This study presents a framework for determining the prioritization of vaccine introduction in the National Immunization Program (NIP) of the Republic of Korea, with a focus on case examples assessed in 2021 and 2023. We describe the predefined criteria for evaluating the prioritization of vaccines in the NIP and the established process in the Republic of Korea. These criteria included disease characteristics, vaccine characteristics, rationality and efficiency of resource allocation, and the acceptance of immunization.

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  • A study in South Korea aimed to investigate the prevalence of congenital heart disease (CHD) in children, filling a gap in national epidemiological data.
  • Researchers analyzed data from the National Health Insurance Service from 2014-2018, focusing on critical CHDs that require immediate intervention after birth.
  • Results showed that prevalence rates for certain defects varied significantly between East Asian and Western populations, indicating unique patterns in CHD types in Korean children.
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Adsorption of alkali atoms onto material surfaces is widely utilized for controlling electronic properties and is particularly effective for two-dimensional materials. While tuning the chemical potential and band gap and creating quantum-confined states are well established for alkali adsorption on semiconductors, the effects on semimetallic systems remain largely elusive. Here, utilizing angle-resolved photoemission spectroscopy measurements and density functional theory calculations, we disclose the creation of two-dimensional electron gas and the quantum-confined Lifshitz transition at the surface of a Weyl semimetal -MoTe by potassium adsorption.

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  • The study investigates the effects of the traditional Korean herb Turczaninow (PU) on reducing hyperimmune responses in the respiratory tract, particularly focusing on inflammatory cytokines and airway inflammation.
  • PU treatment showed a concentration-dependent decrease in key inflammatory markers and increased antioxidant enzyme activity, indicating a positive effect on lung health.
  • Overall, findings suggest that PU is a potential anti-inflammatory agent for treating airway issues, as it helps mitigate inflammation and excessive mucus production.
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Pigmentation changes in canopy leaves were first reported, and subsequent genetic analyses identified a major QTL associated with levels of pigmentation changes, suggesting Glyma.06G202300 as a candidate gene. An unexpected reddish-purple pigmentation in upper canopy leaves was discovered during the late reproductive stages in soybean (Glycine max L.

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This study conducted real-time monitoring of size-resolved particle concentrations ranging from 9 nm to 10 μm simultaneously at four sites on the park ground and the roof of a five-story apartment buildings in the upwind and downwind areas of the Olympic Expressway next to apartment complex areas of Seoul, Korea. Using a positive matrix factorization model for source apportionment, eight factors were resolved at each monitoring site: four exhaust emissions of vehicles, one non-exhaust emission of vehicle, two regional sources, and one unknown source. After categorizing monitoring data into three cases by wind conditions, impact and contribution of each vehicle-related source on the local road to the roadside pollution was quantified and characterized by subtracting the urban background concentrations.

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