Molecular mechanism of RBM14-mediated promotion of proliferation, migration, and invasion in osteosarcoma.

Background: Osteosarcoma (OS) is an exceptionally aggressive bone neoplasm that predominantly impacts the paediatric and adolescent population, exhibiting unfavourable prognosis. The importance of RNA binding motif protein 14 () in the aetiology of OS is not well understood, despite its established involvement in several other types of cancer.

Methods: In this study, we conducted an analysis of the expression profiles of in cancer tissues and cell lines.

Molecular Structure Engineering of Isomeric Additives for Long Lifetime Zn Anodes.

Modulating the solvation structure of hydrated zinc ions using organic additives stands as a pragmatic approach to suppress dendrite formation and corrosion on zinc metal anodes (ZMAs), thereby enhancing the rechargeability of aqueous Zn-ion batteries. However, fundamental screening principles for organic additives with diverse molecular structures remain elusive, especially for isomers with the same molecular formula. This study delves into the impact of three isomeric hexagonal alcohols (mannitol, sorbitol, and galactitol) as additives in adjusting Zn solvation structural behaviors within ZnSO baseline electrolytes.

Fracture Resistant CrSi-Doped Silicon Nanoparticle Anodes for Fast-Charge Lithium-Ion Batteries.

Lithium-ion batteries (LIBs) has been developed over the last three decades. Increased amount of silicon (Si) is added into graphite anode to increase the energy density of LIBs. However, the amount of Si is limited, due to its structural instability and poor electronic conductivity so a novel approach is needed to overcome these issues.

d-Band Center Optimization of TiCT MXene Nanosheets for Ultrahigh NO Gas Sensitivity at Room Temperature.

MXene exhibits numerous advantageous properties such as high electronic conductivity, high surface area, and ease of surface modification via tailoring of functional groups. However, the mechanism by which MXene functionalization enhances gas sensing performance has not yet been well understood, let alone the development of a rational sensor design optimization strategy. This work presents a functionalization methodology for MXene based on d-band center modulation, which can be implemented by introducing Fe onto the surface of TiCT nanosheets, for significantly improved gas sensing response and selectivity.

Atomic Plasma Grafting: Precise Control of Functional Groups on TiCT MXene for Room Temperature Gas Sensors.

Gas sensing properties of two-dimensional (2D) materials are derived from charge transfer between the analyte and surface functional groups. However, for sensing films consisting of 2D TiCT MXene nanosheets, the precise control of surface functional groups for achieving optimal gas sensing performance and the associate mechanism are still far from well understood. Herein, we present a functional group engineering strategy based on plasma exposure for optimizing the gas sensing performance of TiCT MXene.

Bone marrow mesenchymal stem cell-derived exosomal LINC00847 inhibits the proliferation, migration, and invasion of Ewing sarcoma.

Background: Ewing sarcoma (ES) is one of the most lethal primary bone tumors with a poor survival rate. Current evidence suggests that extracellular vesicles (EVs) derived from bone marrow mesenchymal stem cells (BMSCs) loaded with abundant biological functional lncRNAs confer therapeutic benefits against the development of various tumors.

Aim: This study aimed to investigate the role of exosomal lncRNAs from BMSCs in the pathogenesis of ES.

Synergetic Chemistry and Interface Engineering of Hydrogel Electrolyte to Strengthen Durability of Solid-State Zn-Air Batteries.

For the challenging pursuit of high energy efficiency and mechanical tolerance in flexible solid-state Zn-air batteries (FSZABs), a hydrogel electrolyte (HE) consisting of dual-network crosslinked polyacrylic acid-Fe -chitosan (PAA-Fe -CS) polymer host infiltrated with a mixed aqueous electrolyte of NH Cl and ZnCl is developed. The absorbed near-neutral electrolyte renders the HE high ionic conductivity but low corrosiveness to both electrocatalysts and Zn metal anode (ZMA), ensuring more stable Zn-OH-O chemistry compared to that in strong alkaline electrolyte and thus endowing the assembled FSZABs with a landmark cycle life up to 120 h (5 mA cm ). More intriguingly, the CS molecular beams introduced into the PAA hydrogel backbone will precipitate and fold subjecting to the Hofmeister effect when saturated with the near-neutral electrolyte, which can effectively enhance the interfacial adhesion strength of the HE on both air cathode and ZMA, achieving reliable and robust bonding between them.

Characteristics of chitosan fiber and their effects towards improvement of antibacterial activity.

We selected eight kinds of chitosan fibers to characterize and analyze their composition, surface morphology, and mechanical properties. Crucially, we investigated their antibacterial activity against Escherichia coli, Staphylococcus aureus and Candida albicans and the dependence on the molecular weight (Mw) and the degree of deacetylation (DD). On that basis, the relationship between antibacterial activity and Mw and DD can be established.

Chitosan Natural Polymer Material for Improving Antibacterial Properties of Textiles.

In recent years, the textile industry has been seeking to develop innovative products. It is a good choice to organically combine materials with superior functional characteristics and commercial textiles to form products with excellent performance. In particular, textiles made of biological functional materials are often beneficial to human health, which is an interesting research direction.

Ion Sieve: Tailoring Zn Desolvation Kinetics and Flux toward Dendrite-Free Metallic Zinc Anodes.

Tip-induced dendrites on metallic zinc anodes (MZAs) fundamentally deteriorate the rechargeability of aqueous Zn metal batteries (ZMBs). Herein, an intriguing ion sieve (IS) consisting of 3D intertwined bacterial cellulose, deposited on the surface of MZAs (Zn@IS) through an in situ self-assembly route, is first presented to be effective in inhibiting dendrite-growth on MZAs. Experimental analyses together with theoretical calculations suggested that the IS coating can facilitate the desolvation of [Zn(HO)] clusters via a strong interplay with Zn ions, weaken hydrogen evolution reaction of MZAs, and homogenize the ion flux with the abundant nanopores serving as ion tunnels, synergistically enabling dendrite-free Zn deposition on the Zn@IS anodes.

Interlayer Structure Engineering of MXene-Based Capacitor-Type Electrode for Hybrid Micro-Supercapacitor toward Battery-Level Energy Density.

Micro-supercapacitors are notorious for their low energy densities compared to micro-batteries. While MXenes have been identified as promising capacitor-type electrode materials for alternative zinc-ion hybrid micro-supercapacitors (ZHMSCs) with higher energy density, their tightly spaced layered structure renders multivalent zinc-ions with large radii intercalation inefficient. Herein, through insertion of 1D core-shell conductive BC@PPy nanofibers between MXene nanosheets, an interlayer structure engineering technique for MXene/BC@PPy capacitor-type electrodes towards ZHMSCs is presented.

A data-driven approach to predicting the attachment density of biofouling organisms.

The attachment efficiency of biofouling organisms on solid surfaces depends on a variety of factors, including fouler species, nutrition abundance, flow rate, surface morphology and the stiffness of the solid to which attachment is to be made. So far, extensive research has been carried out to investigate the effects of these factors on the attachment of various fouling species. However, the results obtained are species-dependent and scattered.

Combat biofouling with microscopic ridge-like surface morphology: a bioinspired study.

Biofouling refers to the unfavourable attachment and accumulation of marine sessile organisms (e.g. barnacles, mussels and tubeworms) on the solid surfaces immerged in ocean.

c-axis preferential orientation of hydroxyapatite accounts for the high wear resistance of the teeth of black carp (Mylopharyngodon piceus).

Biological armors such as mollusk shells have long been recognized and studied for their values in inspiring novel designs of engineering materials with higher toughness and strength. However, no material is invincible and biological armors also have their rivals. In this paper, our attention is focused on the teeth of black carp (Mylopharyngodon piceus) which is a predator of shelled mollusks like snails and mussels.