A Key Role of the EMC Complex for Mitochondrial Respiration and Quiescence in Fission Yeasts.

In eukaryotes, oxygen consumption is mainly driven by the respiratory activity of mitochondria, which generates most of the cellular energy that sustains life. This parameter provides direct information about mitochondrial activity of all aerobic biological systems. Using the Seahorse analyzer instrument, we show here that deletion of the oca3/emc2 gene (oca3Δ) encoding the Emc2 subunit of the ER membrane complex (EMC), a conserved chaperone/insertase that aids membrane protein biogenesis in the ER, severely affects oxygen consumption rates and quiescence survival in Schizosaccharomyces pombe yeast cells.

Structural, Magnetic, Optical and Photocatalytic Properties of Co-Doped ZnO Nanocrystals.

Energy levels associated with several crystalline defects, such as zinc (V) and oxygen (V) vacancies, Zn and O interstitials (Zn and O respectively), Zn and O antisite defects, and charged oxygen vacancies Vo-, among others, are generated by the introduction of cobalt (Co) into the structure. The effective introduction of Co into the Zn occupancy site was evaluated by XRD and electron paramagnetic resonance. The EPR spectra remain consistent across all doping concentrations of Co ions and revealed intriguing features linked to four distinct Co paramagnetic centers; among them, a pair of Co ions exhibited ferromagnetic coupling.

Dental Restorative Viability of Zinc Oxide Nanoparticle-Reinforced Zirconia and Baghdadite Ceramic Composites.

This study explores the enhancement of properties in zirconia-based ceramic dental restorative materials through the incorporation of baghdadite (CaZrSiO) and zinc oxide (ZnO) nanoparticles. Baghdadite was synthesized via a solid-state sintering method and integrated into zirconia to form baghdadite/zirconia ceramic composites. These composites were sintered with varying concentrations of baghdadite (0%, 5%, and 10%) to enhance bioactivity and support bone tissue repair, and incorporated with 0.

Integrated modelling of anaerobic digestion process chain for scenario assessment.

Anaerobic digestion (AD) expansion as a renewable energy source offers environmental benefits, such as reducing mineral fertilizer use and preserving soil organic matter. However, poor AD performance can cause greenhouse gas emissions and nutrient loss, impacting efficiency. To address this, an innovative AD process chain (ADPC) model was developed to dynamically simulate biogas production, organic matter bioaccessibility, digestate phase separation, storage, and soil application, focusing on carbon and nitrogen dynamics.

Race, Genetics, and Social Determinants of Health in Transthyretin Cardiac Amyloidosis: A Literature Review and Call to Action.

Purpose Of Review: Recent evidence suggests that transthyretin cardiac amyloidosis (ATTR-CM) is significantly more common than once believed, yet it remains frequently under- and mis-diagnosed. With effective treatments now available, early and accurate diagnosis has become critical for better patient outcomes. Understanding the interplay between genetics, race, and social determinants of health (SDOH) in influencing both ATTR-CM diagnosis and management is essential for bridging the current gaps.

Trends and outcomes of heart failure hospitalizations during COVID-19 pandemic.

Background: COVID-19 has affected many hospitalizations. In this study, we intended to understand the effects of COVID-19 pandemic on heart failure hospitalizations in the state of California.

Method: This study was a retrospective analysis of California State Inpatient Database during March to December of 2019 and 2020.

Evaluation of Women with Peripartum or Dilated Cardiomyopathy and Their First-Degree Relatives: The DCM Precision Medicine Study.

Background: Peripartum cardiomyopathy (PPCM) presents substantial risk of maternal mortality, but underlying cause remains unsettled.

Methods: We compared the prevalence of dilated cardiomyopathy (DCM)-relevant genetic variants in 452 female patients (probands) of African and European ancestry (AA, EA) with PPCM or DCM who had been pregnant at least once. Pathogenic and likely pathogenic (P/LP) variants were identified in DCM-associated genes.

New biomarkers and scintigraphic evaluation of renal function in dogs with canine leishmaniosis.

This study evaluated the utility of new renal biomarkers in canine leishmaniosis (CanL). A total of 6 healthy dogs (CG) and 22 dogs with CanL (LeishVet stage III or GIII (n = 11) and stage IV or GIV (n = 11)) were included. Plasma creatinine, urea, cystatin C (pCysC), and symmetric dimethylarginine were analyzed.

The role of marine debris as a vector, dispersal agent, and substrate for non-indigenous species on Oceanic Islands (Northeast Atlantic).

Marine debris (MD) can be a transport vector for diverse marine communities, including non-indigenous species (NIS). This study assessed MD potential role as a substrate for colonization and dispersal vector for NIS in the Madeira Archipelago (NE Atlantic) by examining three MD categories: floating (FMD), seafloor (SMD), and beached (BMD). Opportunistic sampling, conducted in collaboration with local maritime stakeholders, documented MD sightings with photographs and GPS coordinates.

Organizational change using a novel, structured plan for justice, equity, diversity, and inclusion (JEDI) in an academic surgical department.

Introduction: Ethnic, gender-based, socioeconomic, and racial inequities persist in academic medical centers across the United States. Integration of principles of justice, equity, diversity, and inclusion (JEDI) with policies, procedures and organizational culture remains a challenge for many departments of Surgery.

Methods: Starting in June of 2021, we implemented a structured justice, equity, diversity, and inclusion plan with the goal of enhancing organizational and cultural change within our department.

Porous Mortars Incorporating Active Biochar from Olive Stone Waste and Recycled Masonry Aggregate: Effects of Accelerated Carbonation Curing.

This study investigated the use of activated biochar derived from olive stone waste and recycled masonry aggregates in porous mortar mixtures and assessed their behaviour under accelerated carbonation curing conditions. Three mortar mixtures were produced, incorporating 0%, 5%, and 10% activated biochar by volume. The physical, chemical, and mechanical properties of the mortars were analysed, including the compressive strength, flexural strength, water absorption, porosity, and CO capture capacity.

A Tablet-Based Curriculum-Based Measurement Protocol for Kindergarten Writing.

Kindergarten writing involves acquiring fundamental skills, such as letter formation, phonemic awareness, and the gradual use of written language to express ideas. In this context, tablet-based curriculum assessments present new opportunities for teaching and evaluating these early writing abilities. To the best of our knowledge, there is currently no tool with these features available for Spanish-speaking children.

Modulating the spin-flip rates and emission energies through ligand design in chromium(iii) molecular rubies.

Three homoleptic spin-flip (SF) emitters, namely [Cr(Mebipzp)] (1), [Cr(IMebipzp)] (2) and [Cr(bip*)] (3), have been successfully synthesized and characterized. The weak distortion compared to a perfect octahedron imparts favourable structural properties to the three complexes, which display spin-flip (SF) luminescence at approximately 740 nm with quantum yields in the range of 9-11% for 1 and 2 in deaerated acetonitrile solutions at 25 °C. Time-resolved luminescence and transient UV-vis absorption experiments unveiled lifetimes for the lowest-lying MC (metal-centered) of 1.

Connecting the uninsured to care: Engaging new primary care patients at a new York City safety net system.

Objective: Cost and ineligibility are major barriers to accessing United States health care, particularly for undocumented immigrants. NYC Care is a healthcare benefit program covering care at NYC Health+Hospitals, the nation's largest safety net system located in New York City. In this evaluation, we describe care received by new primary care patients recently enrolled in NYC Care.

Prenatal VEGF Nano-Delivery Reverses Congenital Diaphragmatic Hernia-associated Pulmonary Abnormalities.

Rationale: Congenital diaphragmatic hernia (CDH) results in lung hypoplasia. In severe cases, tracheal occlusion (TO) can be offered to promote lung growth. However the benefit is limited, and novel treatments are required to supplement TO.

Ethnoracial disparities in gray matter atrophy are mediated by structural disconnectivity in multiple sclerosis.

Objective: To investigate ethnoracial disparities in gray matter (GM) atrophy, the contribution of white matter lesions and consequent structural disconnectivity among patients with multiple sclerosis (MS).

Methods: This retrospective study included 297 patients with MS (pwMS), 98 Hispanic/Latinx (H-MS), 82 non-Hispanic Black (B-MS), and 117 non-Hispanic White (W-MS). GM atrophy was assessed using univariate, voxel-based morphometry, and multivariate techniques, source-based morphometry.

Use of Midodrine for Intraoperative Hemostasis in Cutaneous and Percutaneous Surgery.

Owing to the increasingly high volume of cutaneous and percutaneous procedures performed annually, the demand for local anesthesia has steadily risen. The gold-standard formulations for local anesthesia contain epinephrine at a concentration of 1:100,000 added to lidocaine to aid in hemostasis. Epinephrine, an α-agonist, also exhibits off-target β-adrenergic effects that carry risk of adverse events with these injections.

Chemotherapy-Induced Alopecia in Ovarian Cancer: Incidence, Mechanisms, and Impact Across Treatment Regimens.

Background/objectives: Ovarian cancer is the fifth most common cancer among women, with an estimated 19,680 new cases projected in 2024. Adjuvant chemotherapy remains the standard treatment for epithelial ovarian cancers but is frequently associated with adverse events, such as chemotherapy-induced alopecia (CIA). CIA is a particularly distressing side effect that significantly affects the body image, self-esteem, and quality of life of patients.

Active search for tuberculosis in three youth detention centers in Peru.

Motivation for the study. With tuberculosis being the leading cause of death due to infectious diseases in the world, and having a detection gap of 20-40%, there is a need to implement active search strategies for the disease in different vulnerable populations such as juvenile correctional facilities. Main findings.

Identifying Daytime Hypercapnia Using Transcutaneous Carbon Dioxide Monitoring in Patients With Amyotrophic Lateral Sclerosis.

Introduction/aims: Respiratory failure from hypoventilation is the most common cause of death in amyotrophic lateral sclerosis (ALS). However, ALS care rarely assesses hypercapnia, a physiologic measure of hypoventilation. We investigated the prevalence and clinical significance of daytime hypercapnia measured by transcutaneous carbon dioxide (tcCO) monitoring in patients with ALS.

Analysis of the dynamics of transition from non-colonization to colonization and bacteremia in hemodialysis patients using Markov models.

Background: Hemodialysis patients are frequently colonized by , leading to severe infections with high mortality rates. However, little is known about transition from non-colonization to colonization or bacteremia over time. The aim was to analyze the behavior of colonization, identifying the probability of transition from non-colonized to colonized state or bacteremia, and the influence of specific covariates.

Early Sedation with Dexmedetomidine in Patients with Acute Myocardial Infarction Requiring Mechanical Ventilation.

Background And Aims: Patients with acute myocardial infarction (AMI) who require invasive mechanical ventilation (IMV) represent a critically ill population with limited data on optimal sedative and analgesic use. Clinical trials assessing dexmedetomidine use exclude or poorly represent patients with AMI. This study aimed to compare the use of early sedation with dexmedetomidine to usual-care sedation in patients with AMI requiring IMV.