Publications by authors named "Jimena Borgo"

Article Synopsis
  • * This study investigates the cestocidal (tapeworm-killing) potential of four South American plant species known for their medicinal properties, all of which exhibited some degree of effectiveness against cestodes.
  • * Among the findings, the compound estafietin, extracted from one of the plants, showed a strong ability to kill parasites and alter their morphology in a dose-dependent manner, indicating its potential as a new treatment for neglected tropical diseases.
View Article and Find Full Text PDF

Chagas disease, caused by the protozoan , affects 6-7 million people worldwide. The dichloromethane extract obtained from the aerial parts of var showed trypanocidal activity in vitro. The fractionation of the dewaxed organic extract via column chromatography led to the isolation of three diterpenoids: -9α,11α-dihydroxy-15-oxo-kaur-16-en-19-oic acid or adenostemmoic acid B, (16)--11α-hydroxy-15-oxokauran-19-oic acid and -11α-hydroxy-15-oxo-kaur-16-en-19-oic acid.

View Article and Find Full Text PDF

Asteraceae (Compositae), commonly known as the sunflower family, is one of the largest plant families in the world and includes several species with pharmacological properties. In the search for new antiviral candidates, an in vitro screening against dengue virus (DENV) was performed on a series of dichloromethane and methanolic extracts prepared from six Asteraceae species, including , , , , , and , along with pure phytochemicals isolated from Asteraceae: mikanolide (), eupatoriopicrin (), eupahakonenin B (), minimolide (), estafietin (), 2-oxo-8-deoxyligustrin (), santhemoidin C (), euparin (), jaceidin (), nepetin (), jaceosidin (), eryodictiol (), eupatorin (), and 5-demethylsinensetin (). Results showed that the dichloromethane extracts of and and the methanolic extracts prepared from and were highly active and selective against DENV-2, affording EC values of 0.

View Article and Find Full Text PDF

species (Asteraceae) have been a rich source of terpenoid compounds, mainly sesquiterpene lactones, several of which show antiprotozoal activity. In the search for new trypanocidal compounds, var. and were studied.

View Article and Find Full Text PDF

The genus (Asteraceae) comprises around 230 species, distributed from the southern United States to the South American Andean region. , a Paraguayan herb that produces an intensely sweet diterpene glycoside called stevioside, is the most relevant member of this genus. Apart from , many other species belonging to the genus are considered medicinal and have been popularly used to treat different ailments.

View Article and Find Full Text PDF

The anti- activity of extracts from 13 Argentinean Asteraceae species was determined. Dichloromethane and methanol extracts of , , and were evaluated against epimastigotes, , , , , and dichloromethane extracts showed trypanocidal activity with inhibitions higher than 60% at a concentration of 10 µg/mL. The methanol extracts of and were the most active with inhibitions of 70.

View Article and Find Full Text PDF

A PHP Error was encountered

Severity: Notice

Message: fwrite(): Write of 34 bytes failed with errno=28 No space left on device

Filename: drivers/Session_files_driver.php

Line Number: 272

Backtrace:

A PHP Error was encountered

Severity: Warning

Message: session_write_close(): Failed to write session data using user defined save handler. (session.save_path: /var/lib/php/sessions)

Filename: Unknown

Line Number: 0

Backtrace: