Insights into the Overlap of Chronic Obstructive Pulmonary Disease and Sleep Apnea: Experience from the Clinic of Pneumology, Târgu Mureș.

Introduction: Chronic obstructive pulmonary disease (COPD) has a severe impact on patients' health and can lead to multiple complications.

Material And Methods: We analyzed the co-occurrence of obstructive sleep apnea (OSA) in COPD patients hospitalized in the Pneumology Clinic of Târgu Mureș, Romania.

Results: A total of 150 COPD patients were investigated by clinical examination, STOP-BANG and Epworth questionnaires, ventilatory polygraphy (PG), EKG, cardiac ultrasound, blood lipids, and sugar.

Severe Uncontrolled Asthma: A Longitudinal Retrospective Study Illustrating the Experience of the Pulmonology Clinic of Târgu-Mureș, Romania.

Severe uncontrolled asthma (SUA) affects approximately 5% of asthma patients, leading to frequent exacerbations, reduced lung function, and lower quality of life. Recent biologic therapies target specific inflammatory pathways, offering new options for SUA. : This study aimed to evaluate clinical characteristics, treatment outcomes, and biomarkers in patients with SUA treated with biologics (Omalizumab, Benralizumab, and Dupilumab) at our clinic.

Comorbidities and Laryngeal Cancer in Patients with Obstructive Sleep Apnea: A Review.

: The global prevalence of obstructive sleep apnea shows that this disease appears in 1 billion people, with the prevalence exceeding 50% in some countries. Treatment is necessary to minimize negative health impacts. Obstructive sleep apnea (OSA) is defined as a cause of daytime sleepiness, as well as a clinical manifestation of sleep-disordered breathing.

[Exacerbation of obstructive pulmonary diseases by SARS-CoV-2 infection in patients treated in the Pulmonology Clinic of Târgu Mures].

Introduction: Literature data show an increased severity of SARS-CoV-2 infection in patients with cardiovascular, renal comorbidities, chronic obstructive pulmonary disease (COPD), asthma, obesity, diabetes, tumors and immunosuppression.

Method: This retrospective study includes 90 patients with SARS-CoV-2 infection associated with COPD or asthma exacerbations from 303 patients hospitalized during a 7-month period (29.7%).

[Characteristics of the association between tuberculosis and HIV infection in Mures county, Romania].

Introduction: Despite the decrease in morbidity due to human immunodeficiency virus (HIV) infection in Romania, it remains a significant risk factor for tuberculosis.

Objective: Analyzing the characteristics of tuberculosis-HIV co-infection in Maros county, Romania, during 2014-2020.

Method: Retrospective data processing of the study group and comparing with internationally reported data (similar group, same geographic region, during 2004-2013).

[Lung function and comorbidities in patients with exacerbated chronic obstructive pulmonary disease hospitalized in Tirgu-Mureș Pulmonology Clinic].

two-thirds and partial remission in one-third of the lesions. At doses above 100 J/cm², severe erythema was observed 24 hours after the treatment. To avoid this, we calculated the time to be spent outdoor by dosimetry.

Applicability of lung ultrasound in the assessment of COVID-19 pneumonia: Diagnostic accuracy and clinical correlations.

Background: The purpose of this study was to assess the diagnostic accuracy of lung ultrasound (LUS) in determining the severity of coronavirus disease 2019 (COVID-19) pneumonia compared with thoracic computed tomography (CT) and establish the correlations between LUS score, inflammatory markers, and percutaneous oxygen saturation (SpO).

Methods: This prospective observational study, conducted at Târgu-Mureș Pulmonology Clinic included 78 patients with confirmed severe acute respiratory syndrome coronavirus-2 infection via nasopharyngeal real-time-polymerase chain reaction (RT-PCR) (30 were excluded). Enrolled patients underwent CT, LUS, and blood tests on admission.

[Extrapulmonary tuberculosis - a diagnostic and therapeutic challenge].

Allograft degeneration can be effectively treated with the use of covered stents. Transaxillary approach is an alternative to a compromised transfemoral access. Ipsilateral transradial access may increase the safety of a percutaneous transaxillary puncture.

A rare association of cutaneous leukocytoclastic angiitis (hypersensitivity vasculitis) and hypersensitivity pneumonia (extrinsic allergic alveolitis) in a pigeon breeder - case report and literature review.

Extrinsic allergic alveolitis is an occupational condition intensively studied and published about, unlike cutaneous leukocytoclastic angiitis. The coexistence of these two diseases is even more rare in the same patient with exposure to occupational pollutants of animal origin. We present the case of a 44-year-old man, a pigeon breeder admitted to hospital with a pruritic purpuric eruption and lower limb paresthesia, dyspnea on exertion, polymyalgia rheumatica, mixed polyarthralgias.

Modified enteromesenteric bridging operation for primary lymphedema.

Background: Primary lymphedema represents a condition which affects the lymph vessels and their cells without any pathologic patient history leading to soft tissue swelling. They are described in the literature three types: congenital primary lymphedema, or Milroy disease, lymphedema praecox, which occurs in puberty, and lymphedema tarda, when, the same symptoms, develop over 35 years old patients. The aim of this paper is to present a modified Kimmoth's original procedure for a praecox lymphedema by introducing an omental flap in the resorptive area.

Pulmonary Langerhans cell histiocytosis in a 26-year-old female: still a diagnostic challenge.

Langerhans cell histiocytosis (LCH) is a rare disorder caused by monoclonal Langerhans cells proliferation in bone, skin, lung, lymph nodes, liver, spleen, nervous or hematopoietic system. Pulmonary LCH is a diagnostic trap that is displayed on computed tomography (CT) as an interstitial disorder with honeycomb aspect. In this paper, we present an unusual case of a 26-year-old female that was hospitalized with progressive worsening dyspnea and history of recurrent pneumonia.

Laparoscopic gastric plication for the treatment of morbid obesity by using real-time imaging of the stomach pouch.

Background: Bariatric surgery is a continuously evolving field. Laparoscopic greater curvature plication is a new investigational procedure used to treat patients with morbid obesity. The demand for this operation from the obese patients is also rising.

Tuberculosis and its particularities in Romania and worldwide.

Tuberculosis (TB) is a global health issue, with a rising incidence since the beginning of this century. It poses a severe mortality risk and also poses a serious economic risk as it reduces the working capacity of an individual in the most productive part of life. Developing countries face widespread tuberculosis infection - up to 95% of all cases and 98% of deaths, respectively.

Crossover iliofemoral bypass graft through tension-free abdominal wall-repair mesh.

Introduction: In vascular surgery the crossover iliofemoral bypass grafting is a well-known surgical technique. In general surgery the repair of an abdominal defect using a Polypropylene mesh is also a standard procedure. A particular technique is defined by the performance of these 2 separate procedures inside a single operation in which the crossover arterial graft is directed from the retroperitoneal space toward the contra-lateral femoral bifurcation through a Polypropylene mesh which closes the musculoaponeurotic layers of the abdominal wall.

The role of quantitative computed tomography in the diagnosis of chronic obstructive pulmonary disease.

In the last 25 years, there have been important improvements in computed tomography (CT) that may give more details about the lung structure in chronic obstructive pulmonary disease (COPD). The clinical exam and “classic” radiology (chest X-ray, conventional CT) have important roles: they raise the suspicion of hyperinflation, they highlight aspects of pulmonary hypertension, they may detect the triggers of exacerbations, they rule out some COPD complications and other lung diseases that can cause dyspnea (pneumothorax, tumors, bronchiectasis, and fibrosis). The spirometry may confirm the obstructive ventilatory disorder pattern of the disease.

Advanced Sarcoidosis with Apparent Onset by Respiratory Failure.

We present the case of a 14 years-old male (with poor living condition, non-smoker) hospitalized for a sudden onset of a rest dyspnea, mucopurulent cough. We found bronchial sibilant rales, wheezing, cyanosis, peripheral adenopathies, hepatosplenomegaly, purulent tonsillitis. the chest-x-ray revealed bilateral mediastinal lymphadenopathy and bilateral lung infiltrations.

Multimacronodular pulmonary tuberculosis (bacteriologically negative) confirmed histologically.

Background: Pulmonary tuberculosis can be confirmed by positive bacteriology of sputum, bronchial aspirate or by biopsies (microscopy and/ or culture) or by histopathological examination highlighting specific tuberculous granulomas. When microscopy is repeatedly negative during noninvasive methods, lung biopsy by thoracoscopy is needed for confirmation and differential diagnosis.

Case Presentation: A 40-year-old female patient (nonsmoker, diabetic, with previous exposure to chemicals) was admitted to the hospital for weight loss, dry cough, loss of appetite, pallor, and fatigue.

Basic thoracic ultrasound for the respiratory physician.

Thoracic ultrasound (TUS) evolved in the last ten years as the method of choice for evaluating pleural abnormalities and for guiding lung procedures. TUS can "see" almost all structures in the chest, including thoracic wall, pleura, pleural space, the heart, the great vessels and the peripheral layers of the lungs. However, there is still a great need to develop TUS services in respiratory departments in Romania.

Neuroendocrine pancreatic tumor - diagnosis circumstances, staging and treatment: a case report.

Neuroendocrine neoplasms (NENs) of the pancreas are rare and frequently malignant. Our presentation of a pancreatic NEN analyzes the diagnosis circumstances, staging, treatment, one-year evolution and disease particularities. A 39-year-old nonsmoker patient was admitted in the Clinic of Pulmonology, Tirgu Mures, Romania with a pneumonia suspicion (fever, thoracic pain irradiated below the diaphragm, mild dyspnea).

[Gastroesophageal reflux and asthma--pathogenetic mechanisms and treatment].

Gastroesophageal reflux and bronchial asthma are frequently encountered comorbidities that maintain an ambivalent relationship, generating a vicious circle where gastroesophageal reflux increases asthmatic symptoms or precipitates bronchial asthma and asthma can trigger or worsen gastroesophageal reflux disease. Pathogenetic mechanisms of these interrelation are imperfectly understood, despite intense concerns of specialists in both areas. There have been incriminated: eso-bronchial constrictor vagal mediated reflexes, bronchial hyperreactivity, neurogenic inflammation induced by hydrochloric acid penetration in the oesofagus, airways hydrochloric acid microaspiration with asthmatic trigger effects, increased bronchial resistance or increased immune response to antigens.

[Solitary pulmonary nodule: diagnosis criteria and management].

The solitary pulmonary nodule (SPN) is a frequent aspect on the chest X-ray and computed tomography (CT). The diagnosis and management of the SPN is not yet standardized. A high percentage of the SPNs is represented by the malignant lesions (primary lung cancer or metastasis of other extra pulmonary tumors).