Decision Support for Signal Assessment of Large Case Series in Pharmacovigilance.

In pharmacovigilance, signal assessment of a medicinal product and adverse event can involve reviewing prohibitively large numbers of case reports. A prototype of a decision support tool guided by a needs assessment was developed to help manual review of many reports. In a preliminary qualitative evaluation, users said the tool was easy to use, improved efficiency and provided new insights.

Formation of the first three gravitational-wave observations through isolated binary evolution.

During its first four months of taking data, Advanced LIGO has detected gravitational waves from two binary black hole mergers, GW150914 and GW151226, along with the statistically less significant binary black hole merger candidate LVT151012. Here we use the rapid binary population synthesis code COMPAS to show that all three events can be explained by a single evolutionary channel-classical isolated binary evolution via mass transfer including a common envelope phase. We show all three events could have formed in low-metallicity environments (Z=0.