Rhabdomyolysis as the first manifestation of human immunodeficiency virus infection.

Renal tubular acidosis (RTA) is a known complication of anti-retroviral medications. The presence of RTA in treatment naive-HIV patients is rare. A 49-year-old Caucasian woman presented with recurrent non-anion gap metabolic acidosis, AKI, rhabdomyolysis and hypokalemia on several occasions.

Acute rapamycin nephrotoxicity in native kidneys of patients with chronic glomerulopathies.

Background: Based on its success as a transplant immunosuppressor, there is intense interest in using rapamycin in the treatment of progressive glomerulopathies involving native kidneys. However, we call attention to the potential toxicity associated with the use of rapamycin in this setting.

Methods: We conducted a study to examine the efficacy and safety of rapamycin in patients with progressive chronic renal failure.