Precision medicine for patients with salivary gland neoplasms: Determining the feasibility of implementing a next-generation sequencing-based RNA assay in a hospital laboratory.

Objective: Diagnosing neoplasms of the salivary gland is challenging, as morphologic features of these tumors are complex, and well-defined diagnostic categories have overlapping features. Many salivary gland neoplasms are associated with recurrent genetic alterations. The utilization of RNA-based targeted next-generation sequencing (NGS) panels for the detection of cancer-driving translocations and mutations is emerging in the clinical laboratory.

Endoscopic Proximal Hamstring Tendon Repair With Knotless Suture-Bridge Technique.

Symptomatic proximal hamstring tendon tears are typically repaired surgically, with open incision and knot-tying technique. An endoscopic, knotless, suture-bridge repair technique is presented. Potential advantages include knotless simplicity, compression over a broad zone to improve tendon-bone healing, and decreased pain secondary to elimination of knots and the open incision and approach.

Tensionable Distal Biceps Tendon Repair With Intramedullary Knotless All-Suture Anchors and FiberLoop w/FiberTag Suture.

Distal biceps tendon rupture is commonly repaired via bicortical drilling, extramedullary cortical button placement, and inlay tendon fixation. A retensionable technique with unicortical drilling, intramedullary knotless all-suture anchors placement, and onlay tendon fixation is presented, incorporating up-to-date advances in tendon-bone healing basic science, biceps tendon/radial tuberosity biomechanics, and knotless all-suture implant technology to facilitate radial tuberosity bone preservation, anatomic footprint restoration, improved suture-tendon connection security, and avoidance of drilling and implant-related injury to the posterior interosseous nerve.

Knotless, Retensionable Posterior Meniscal Root Repair With Anterior Cruciate Ligament Repair TightRope and FiberRing Sutures.

Posterior meniscal root repair techniques continue to evolve, influenced by rapidly increasing clinical interest, surgical technology advances, and biomechanical insights. A posterior meniscal root repair technique is presented, utilizing a knotless, retensionable suspensory construct developed for anterior cruciate ligament repair but is also well suited for meniscal root repair. Benefits include built-in shuttling sutures, knotless technology, and poststressing retensioning capability to ensure maximal final repair security.

Classification of cervical biopsy free-text diagnoses through linear-classifier based natural language processing.

Routine cervical cancer screening has significantly decreased the incidence and mortality of cervical cancer. As selection of proper screening modalities depends on well-validated clinical decision algorithms, retrospective review correlating cytology and HPV test results with cervical biopsy diagnosis is essential for validating and revising these algorithms to changing technologies, demographics, and optimal clinical practices. However, manual categorization of the free-text biopsy diagnosis into discrete categories is extremely laborious due to the overwhelming number of specimens, which may lead to significant error and bias.

Arthroscopic Fixation of Knee Osteochondritis Dissecans With Interlinked Knotless All-Suture Anchors.

Unstable, displaced, and persistently symptomatic osteochondritis dissecans of the knee typically requires surgical treatment. An arthroscopic, knotless fixation method using interlinked all-suture anchors is presented, with potential advantages over other current techniques in fixation over a broad zone, treatment versatility for a wide range of fragment types, retensioning ability after stressing, decreased risk of implant-breakage complications, and avoidance of additional surgery for implant removal.

Molecular Signatures of -Mutated Lung Adenocarcinoma: Analysis of Concomitant , , , and PD-L1 Status.

Background: mutations are the most common oncogenic driver mutations of non-small cell lung cancer (NSCLC) in the Western world. Mutations of the gene are most prevalent in the patient population of current and former cigarette smokers. With the recent pivotal approval of a targeted inhibitor therapy for patients with p.

Arthroscopic Patellar Osteochondral Transplantation.

The undersurface location of the patellar articular cartilage presents unique challenges to osteochondral defect treatment. Current osteochondral grafting techniques and instrumentation require arthrotomy and patellar eversion to access the defect with the necessary perpendicular trajectory. We describe an all-arthroscopic patellar osteochondral grafting technique, with transpatellar retrograde reaming for recipient socket creation and graft fixation, to treat focal patellar cartilage defects.

Outcomes and prognostic contributors in patients with mutated non-small cell pulmonary adenocarcinomas: a single institution experience.

Background: is the most frequently encountered driver mutation in advanced non-small cell lung cancer (NSCLC). With targeted therapy for the most common mutation p.G12C on the horizon, the aim of this study is to retrospectively report outcomes in patients with mutated NSCLC.

Arthroscopic Treatment of Chronic Tibial Spine Malunion.

Reports of surgical resection and internal fixation for symptomatic tibial spine malunion are rare, and the reported techniques typically involve an open surgical approach. We present an all-arthroscopic technique of tibial spine malunion treatment, with selective arthroscopic bone resection below the tibial spine, preserving the anterior cruciate ligament attachment, followed by internal fixation of the tibial spine with a hybrid transtibial and suture-bridge construct using knotless anchors and tape sutures.

Pathology Trainee Redeployment and Education During the COVID-19 Pandemic: An Institutional Experience.

Pathology training programs throughout the United States have endured unprecedented challenges dealing with the ongoing coronavirus disease 2019 pandemic. At Houston Methodist Hospital, the Department of Pathology and Genomic Medicine planned and executed a trainee-oriented, stepwise emergency response. The focus was on optimizing workflows among areas of both clinical and anatomic pathology, maintaining an excellent educational experience, and minimizing trainee exposure to coronavirus disease 2019.

Age-specific 3-year cumulative risk of cervical cancer and high-grade dysplasia on biopsy in 9434 women who underwent HPV cytology cotesting.

Background: High-risk human papillomavirus (HPV)-Papanicolaou (Pap) cotesting is recommended for cervical cancer screening in women aged ≥30 years. The current study analyzed the effectiveness of cotesting on risk management in different age groups.

Methods: A retrospective review of a 5-year cytology database identified 9434 women with HPV-Pap cotesting and follow-up cervical biopsy.

Pectoralis major transfer for anterior-superior subluxation in massive rotator cuff insufficiency.

The purpose of this study was to evaluate the outcome after subcoracoid pectoralis major transfer for anterior-superior shoulder instability in massive rotator cuff insufficiency. Fourteen patients underwent subcoracoid pectoralis major transfer for this debilitating surgical complication. At a mean 17.