Publications by authors named "Jilong Yao"
Introduction: The microbial composition of human breast milk and infant meconium offers critical insights into the early microbial colonization profile, and it greatly contributes to the infant's immune system and long-term health outcomes. However, analyzing these samples often faces technical challenges and limitations of low-resolution using conventional approaches due to their low microbial biomass.
Methods: Here, we employed the type IIB restriction enzymes site-associated DNA sequencing for microbiome (2bRAD-M) as a reduced metagenomics method to address these issues and profile species-level microbial composition.
Anti-Müllerian Hormone Enhances Migration and Invasion in Human Trophoblast Cells.
Ann Clin Lab Sci
November 2024
Objective: Anti-Müllerian hormone (AMH) belongs to the transforming growth factor-β superfamily. Recent evidence shows that AMH and its type II receptor (AMHRII) are expressed by the placenta at term. The physiological role of AMH in trophoblast invasion and migration remains to be elucidated.
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- The study aimed to evaluate the effectiveness and safety of Goserelin acetate (Zoladex) 10.8 mg in patients with uterine fibroids, with assessments made before and after a 12-week treatment period, leading up to surgery.
- After treatment, significant reductions were observed in uterine and fibroid volumes, along with decreased levels of hormones like estrogen, while hemoglobin levels increased, indicating improved anemia symptoms.
- The results indicated that Goserelin acetate is both effective in managing uterine fibroids and safe, with a high incidence of adverse events but overall good tolerance reported among patients.
Article Synopsis
- Metabolites are crucial for monitoring health and therapeutic targets, yet their genetic influences during pregnancy remain largely unexplored.
- A genome-wide association study was conducted using genetic data from 34,394 pregnant Chinese women, identifying 53 metabolite-gene associations, with 23 being new findings.
- The research uncovered significant gene-environment interactions during pregnancy, with half of the associations showing pleiotropy and potential causal links between maternal metabolites and various human traits and diseases.
Background: Periodontitis results from host-microbe dysbiosis and the resultant dysregulated immunoinflammatory response. Importantly, it closely links to numerous systemic comorbidities, and perplexingly contributes to adverse pregnancy outcomes (APOs). Currently, there are limited studies on the distal consequences of periodontitis via oral-gut axis in pregnant women.
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- The study aimed to determine the critical cut-off values for the number of metastatic lymph nodes (nMLN) and lymph node ratio (LNR) that predict outcomes in patients with stage IIICp cervical cancer.
- A cohort of 3,135 patients from 47 hospitals was analyzed, revealing that nMLN > 3 and LNR > 0.11 significantly correlated with poorer overall and disease-free survival rates.
- The findings suggest that higher nMLN and LNR values are associated with worse prognosis in cervical cancer patients, emphasizing the importance of these measurements in treatment outcomes.
Article Synopsis
- The study investigated the relationship between maternal periodontal diseases and adverse outcomes in newborns, specifically focusing on small-for-gestational age (SGA) infants.
- Conducted with 193 healthy pregnant women in their third trimester, the research assessed periodontal health and measured neonatal anthropometric data.
- Results indicated a significant correlation between increased gum disease severity and the risk of SGA, suggesting that maternal oral health may impact newborn health, warranting further research.
Article Synopsis
- A study investigates the lipid composition in seminal plasma to better understand and diagnose necrozoospermia, a condition characterized by the absence of sperm in semen.
- Researchers collected and analyzed samples from patients with both necrozoospermia and normozoospermia, using advanced techniques like liquid chromatography-mass spectrometry to identify key lipid biomarkers.
- The analysis revealed multiple lipid classes, pinpointing specific lipids (LPE(20:4) and TG(4:0_14:1_16:0)) as significant for diagnosing necrozoospermia, suggesting that lipidomics could enhance traditional sperm diagnostics.
The term "fracture" pertains to the occurrence of bones being either fully or partially disrupted as a result of external forces. Prolonged fracture healing can present a notable danger to the patient's general health and overall quality of life. The significance of osteoblasts in the process of new bone formation is widely recognized, and optimizing their function could be a desirable strategy.
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- Meckel-Gruber syndrome (MKS) is a serious genetic disorder that has been linked to defects in primary cilia, with few cases reported related to the TXNDC15 gene across various ethnicities.
- A fetus diagnosed with MKS at 12 weeks underwent extensive genetic testing, revealing a new pathogenic variant in TXNDC15, and preimplantation genetic testing was used to prevent passing this condition to future pregnancies.
- This case not only represents the first TXNDC15 variant identified in the Chinese population but also highlights the potential of genetic testing techniques in managing hereditary diseases like MKS.
Article Synopsis
- Polycystic ovary syndrome (PCOS) and periodontitis may increase women's risks for serious health issues like diabetes and heart disease, and more research is needed to understand how hormonal and metabolic factors connect them.
- A case-control study evaluated 66 women with PCOS against 22 healthy participants, assessing periodontal health and analyzing hormone and inflammatory levels using serum and saliva samples.
- Results found that PCOS patients had deeper gum probing and higher triglyceride and inflammatory levels compared to non-PCOS women, indicating a possible link between the severity of PCOS and periodontal conditions.
Article Synopsis
- - The study investigates the effectiveness of three treatment methods—radical chemotherapy (R-CT), abdominal radical hysterectomy (ARH), and neoadjuvant chemotherapy followed by radical surgery (NACT)—for patients with stage IIIC cervical cancer, focusing on squamous cell carcinoma (SCC) and adenocarcinoma (AC)/adenosquamous cell carcinoma (ASC) histological types.
- - Results show that AC/ASC patients had worse survival outcomes (63.7% overall survival) compared to SCC patients (73.6%), with significant differences in 5-year overall survival and disease-free survival rates depending on the treatment type.
- - The findings suggest that initial treatment significantly affects prognosis, with ARH being
Aim: This study evaluated the connection of periodontal status with the leukocyte profiles of maternal peripheral blood (MPB) and umbilical cord blood (UCB).
Materials And Methods: Ninety-nine pregnant females were recruited, and their data were collected via questionnaire and from medical records, including demographics, systemic conditions, complete blood count (CBC) and C-reaction protein (CRP) level in MPB. Full-mouth periodontal assessment was performed.
Article Synopsis
- Aicardi-Goutières syndrome (AGS) is a rare genetic disorder characterized by early onset neurodegeneration and elevated interferon-α levels, impacting affected families’ reproductive choices.
- The study utilized advanced genetic testing methods, including whole exome sequencing and PGT, to identify mutations in the TREX1 gene and ensure the selection of unaffected embryos for a healthy pregnancy.
- Findings revealed novel TREX1 mutations, confirming the effectiveness of the combined genetic approaches, which aid in understanding AGS and enhance genetic counseling strategies for at-risk couples.
Article Synopsis
- The study compares cancer outcomes for patients with FIGO 2018 stage IIIC cervical cancer treated with three different methods: abdominal radical hysterectomy (ARH), neoadjuvant chemotherapy (NACT), and radical chemoradiotherapy (R-CT).
- Researchers analyzed survival data from 4,086 patients categorized into T1, T2a, T2b, and T3 groups using Kaplan-Meier and Cox regression methods to assess overall survival (OS) and disease-free survival (DFS).
- The results suggest that NACT generally resulted in worse OS and DFS compared to ARH, while R-CT showed comparable outcomes to both ARH and NACT across different tumor
This nested case-control study aimed to investigate the determinants of low birth weight among newborn babies delivered in Shenzhen, Guangdong, China. We recorded socio-demographic data, health status before pregnancy, pregnancy outcomes and complications in a Shenzhen mother and infant cohort. Among 8951 cases, 401 (4.
View Article and Find Full Text PDFObjective: Glucose-6-phosphate dehydrogenase (G6PD) deficiency is an X-linked genetic disorder that results in impaired enzyme activity. The G6PD/6PGD ratio assay was routinely used for G6PD deficiency screening in China, but there is an apparent defect of missed diagnosis in heterozygous females. The study aims to explore the means to improve its accuracy.
View Article and Find Full Text PDFBackground: Fetal growth restriction (FGR) is attributed to various maternal, fetal, and placental factors. Trophoblasts participate in the establishment and maintenance of pregnancy from implantation and placentation to providing nutrition to fetus. Studies have reported that impaired trophoblast invasion and proliferation are among factors driving development of FGR.
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- - This study explored how periodontitis (gum disease) relates to metabolic health and liver function in 219 pregnant women who considered themselves healthy.
- - Results showed that pregnant women with periodontitis had higher BMI, elevated liver enzyme levels (AST), increased blood pressure, and lower good cholesterol compared to those without the disease.
- - The findings suggest that there are significant connections between gum disease and metabolic issues during pregnancy, indicating a need for regular dental check-ups to improve health outcomes for mothers and their babies.
Article Synopsis
- This study assessed the effectiveness of two classification systems (AAP/EFP and CDC/AAP) for identifying periodontal diseases in pregnant women, given the limited research on the topic.
- 204 healthy pregnant females were examined, revealing high agreement between the two classification systems, highlighting that a significant percentage had moderate to severe periodontitis.
- The study proposed a modified scoring tool that incorporates pregnancy phases, which showed improved diagnostic performance and could be useful for general dentists in screening for maternal periodontal issues.
Article Synopsis
- A study was conducted to assess how the number of surgeries performed by a surgeon affects outcomes for women with stage IB1 cervical cancer undergoing laparoscopic radical hysterectomy (LRH).
- The analysis included 1,137 patients and categorized surgeons into low, mid, and high-volume based on the number of surgeries they performed.
- Although high-volume surgeons had shorter operative times and less blood loss, overall survival and disease-free survival rates were similar across all surgeon volume groups, indicating that surgical volume may not significantly influence prognosis.
Purpose: To compare oncological outcomes of laparoscopic radical hysterectomy (LRH) and abdominal radical hysterectomy (ARH) for low-risk cervical cancer.
Method: We retrospectively compared the 3-year overall survival (OS) and 3-year disease-free survival (DFS) of 1269 low-risk cervical cancer patients with FIGO 2009 stage IA2, IB1 and IIA1 with a tumour size < 2 cm, no lymphovascular space invasion (LVSI), superficial stromal invasion and no lymph node involvement on imaging, and who received LRH (n = 672) and ARH (n = 597) between 2009 and 2018 at 47 hospitals.
Results: In the total study population, LRH and ARH showed similar 3-year OS (98.
Association between premature ovarian insufficiency and gut microbiota.
BMC Pregnancy Childbirth
June 2021
Article Synopsis
- Premature ovarian insufficiency (POI) affects ovarian function in women under 40 and can be influenced by various factors, including gut microbiome studies.
- A study analyzed fecal samples from 18 healthy women and 35 women with POI using advanced sequencing techniques, revealing significant hormonal differences between the two groups.
- The findings indicated that women with POI had altered gut microbiome profiles, which correlated with hormonal levels, suggesting potential new insights for understanding and treating POI.
Article Synopsis
- The study aims to define an age-specific reference for low anti-müllerian hormone (AMH) levels and its impact on IVF outcomes in women.
- Researchers conducted a retrospective analysis of 909 women undergoing IVF, establishing a linear regression equation for the age-specific mean AMH levels.
- Findings indicate that women with AMH levels above the 10th percentile had significantly better IVF outcomes, especially in those under 35 years, with higher rates of clinical and ongoing pregnancies.
Objective: The aim of this study was to determine the prevalence of congenital heart defects and examine their association with preeclampsia (PE).
Methods: A clinical-based, retrospective study was conducted in Shenzhen between 2004 and 2017. Data were collected from Shenzhen Maternal and Child Health Hospital Medical Record Database.