Design, Synthesis, and Preliminary Evaluation of [Ga]Ga-NOTA-Insulin as a PET Probe in an Alzheimer's Disease Mouse Model.

Aberrant insulin signaling has been considered one of the risk factors for the development of Alzheimer's disease (AD) and has drawn considerable attention from the research community to further study its role in AD pathophysiology. Herein, we describe the development of an insulin-based novel positron emission tomography (PET) probe, [Ga]Ga-NOTA-insulin, to noninvasively study the role of insulin in AD. The developed PET probe [Ga]Ga-NOTA-insulin showed a significantly higher uptake (0.