Publications by authors named "Jillian K Riveros"
Article Synopsis
- * Researchers investigated the effects of the PDE-5a inhibitor sildenafil and found that it enhances the benefits of exercise by improving microcirculation and exercise capacity in diet-induced obese mice, but not in sedentary mice.
- * In lean mice with reduced endothelial nitric oxide synthase (eNOS), exercise training still improved endurance, indicating that while eNOS function is important, training alone can lead to significant benefits in microcirculation and exercise performance.
Fatty acid binding protein 4 (FABP4) is a lipid chaperone secreted from adipocytes upon stimulation of lipolysis. Circulating FABP4 levels strongly correlate with obesity and metabolic pathologies in experimental models and humans. While adipocytes have been presumed to be the major source of hormonal FABP4, this question has not been addressed definitively in vivo.
View Article and Find Full Text PDFLevels of circulating fatty acid binding protein 4 (FABP4) protein are strongly associated with obesity and metabolic disease in both mice and humans, and secretion is stimulated by β-adrenergic stimulation both in vivo and in vitro. Previously, lipolysis-induced FABP4 secretion was found to be significantly reduced upon pharmacological inhibition of adipose triglyceride lipase (ATGL) and was absent from adipose tissue explants from mice specifically lacking ATGL in their adipocytes (ATGL). Here, we find that upon activation of β-adrenergic receptors in vivo, ATGL mice unexpectedly exhibited significantly higher levels of circulating FABP4 as compared with ATGL controls, despite no corresponding induction of lipolysis.
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