The effect of concurrent clopidogrel and omeprazole administration on clopidogrel metabolism and platelet function in healthy cats.

Background: Some studies in humans show that the concurrent use of clopidogrel and omeprazole decreases plasma clopidogrel active metabolite (CAM) concentrations and clopidogrel antiplatelet effects. Whether this drug interaction occurs in cats is unknown.

Hypothesis: We hypothesized that administration of clopidogrel with omeprazole would decrease plasma CAM concentrations and decrease clopidogrel antiplatelet effects in healthy cats.

Multi-institutional retrospective study investigating blood culture protocols and test positivity in 701 dogs.

Objectives: (i) To determine the influence of specimen collection protocol (timing and specimen quantity), primary disease process, and pre-existing antimicrobial or immunosuppressive therapy on blood culture (BC) positivity and (ii) To determine agreement between urine culture and BC results.

Animals: 701 client-owned dogs.

Methods: Multi-institutional retrospective study (2019-2022).

Adverse effects of trazodone in dogs on primary hemostasis and electrocardiogram: A single-blinded placebo-controlled crossover study.

Background: Trazodone is a serotonin antagonist/reuptake inhibitor medication commonly used for anxiety in dogs. Therapy with selective serotonin reuptake inhibitors in humans is associated with bleeding disorders and increased arrhythmogenesis.

Hypothesis/objectives: To evaluate markers of primary hemostasis and corrected QT (cQT) interval in dogs before and after oral administration of standard dosages of trazodone or placebo.

Evaluation of platelet additive solution for prolonging storage of functional canine platelet concentrate.

Objective: To assess storage lesion development, platelet function, and bacterial growth in canine platelet concentrates (PCs) stored in a platelet additive solution (PAS) or a plasma control at 4°C for 21 days.

Design: Prospective, ex vivo, experimental controlled study.

Setting: University veterinary teaching hospital.

Ionized calcium-to-phosphorus ratio predicts neoplasia in azotemic dogs: a retrospective study of 105 cases.

Objective: To evaluate dogs with total hypercalcemia, azotemia, and normal serum phosphorus concentrations to determine whether a calcium-to-phosphorus ratio (Ca:P) or ionized Ca:P (iCa:P) could be utilized to predict underlying neoplasia.

Animals: 105 dogs were included in the study. Thirty-seven percent (n = 39) had known neoplasia, and 63% (66) had no evidence of neoplasia.

The effects of additive solutions on the development of storage lesions in canine platelet concentrates stored at 4°C.

Objective: To assess platelet storage lesion development as evaluated by measurement of metabolic markers, platelet activation markers, and aggregometry, and determine the occurrence of bacterial growth in platelets stored in platelet additive solution (PAS) at 4°C for 7 days.

Design: Prospective, ex vivo experimental controlled study.

Setting: Research laboratory of a university veterinary teaching hospital.

Use of a videofluoroscopic feeding evaluation to guide management of dogs with congenital idiopathic megaoesophagus.

Background: Evidence-based guidelines for determining dietary management in dogs with megaoesophagus are lacking.

Objectives: This study looked to compare oesophageal clearance times (ECT) of liquid and two food consistencies using a contrast videofluoroscopy feeding evaluation, and to assess if recommendations made based on findings could improve regurgitation and quality of life in dogs with congenital megaoesophagus.

Methods: Twenty-one dogs with congenital megaoesophagus and nine healthy dogs received liquid, slurry, and meatball diets containing barium while in an upright position.

A randomized crossover study of compounded liquid sildenafil for treatment of generalized megaesophagus in dogs.

Objective: To determine whether delivery of compounded liquid sildenafil directly to the stomach of dogs with megaesophagus (ME) would affect esophageal clearance, regurgitation frequency, body weight, or quality of life.

Animals: 10 client-owned otherwise healthy dogs with stable ME.

Procedures: A randomized crossover study was performed.

Development and implementation of a hemovigilance program at a university veterinary teaching hospital.

Objective: To describe the development and implementation of a small animal hemovigilance program at a university veterinary teaching hospital.

Design: Retrospective observational descriptive study performed between October 2014 and March 2019.

Setting: University teaching hospital.

The effects of additive solutions on the development of storage lesions in stored canine platelet concentrates.

Objective: To determine if platelet additive solutions (PAS) decrease the occurrence and degree of platelet storage lesions, maintain platelet function, and extend storage time in vitro beyond 5 days at 22°C when compared to platelets stored in plasma only.

Design: Prospective, ex vivo experimental controlled study.

Setting: Research laboratory in a school of veterinary medicine.

Development and assessment of a formal learning module to educate veterinary students in an intensive care unit about transfusion reactions.

Objective: To develop and assess the instructional efficacy of an online learning module on transfusion reactions in small animals and to evaluate participants' satisfaction of the module.

Design: Randomized controlled trial.

Setting: University teaching hospital.

Survey of owners on population characteristics, diagnosis, and environmental, health, and disease associations in dogs with megaesophagus.

Megaesophagus affects dogs worldwide but limited information is available regarding its characteristics in the general population of dogs. The objectives of this study were to provide information on a large population of dogs diagnosed with megaesophagus in regards to population characteristics, medical and family history, diagnosis, concurrent disease, and predisposing factors. A link to a web-based survey was provided on megaesophagus support websites and 838 eligible surveys were evaluated.

Investigation into the causes of aspirin resistance in healthy dogs.

Antiplatelet effects of acetylsalicylic acid (ASA, aspirin) may be poor in some individuals. Additionally, no method exists for predicting poor ASA response (resistance) in individual dogs. This study's main objective was to determine whether poor ASA response results from pharmacodynamic or pharmacokinetic causes.

In vitro and in vivo assessment of platelet function in healthy dogs during administration of a low-dose aspirin regimen.

Objective: To assess the in vitro and in vivo platelet function of healthy dogs during administration of a low-dose aspirin regimen.

Animals: 16 dogs.

Procedures: Dogs received aspirin (1 mg/kg, PO, q 24 h) for 7 days.