Microleakage and Fracture Resistance of "Infinity Edge" and Cusp Reduction Preparation Designs for Moderate-sized Class II Composites.

Aim: This study aimed to evaluate the marginal microleakage and maximum occlusal fracture loads and fracture modes of two novel class II preparation designs, "infinity edge" and the "2.5 mm cusp reduction" preparations as compared to a traditional class II preparation without cuspal involvement.

Materials And Methods: Thirty extracted human mandibular molars were prepared for moderate-sized class II restorations with extensions into all occlusal grooves.

Does ischial screw fixation improve mechanical stability in revision total hip arthroplasty?

Ischial screw fixation, albeit technically challenging, is postulated to provide additional mechanical stability in revision total hip arthroplasty (THA). Hemipelvis specimens were prepared to simulate revision THA, and an acetabular component with supplemental screw fixation was implanted. Three configurations were tested: 2 dome screws alone, 2 dome screws plus an additional screw within the dome, and 2 dome screws plus an ischial screw.

Gamma-hydroxybutyrate does not maintain self-administration but induces conditioned place preference when injected in the ventral tegmental area.

Gamma-hydroxybutyric acid (GHB) is an endogenous brain substance that has diverse neuropharmacological actions, including rewarding properties in different animal species and in humans. As other drugs of abuse, GHB affects the firing of ventral tegmental neurons (VTA) in anaesthetized animals and hyperpolarizes dopaminergic neurons in VTA slices. However, no direct behavioural data on the effects of GHB applied in the VTA or in the target regions of its dopaminergic neurons, e.