Wild-Type Transthyretin Amyloidosis: A Prevalent and Underdiagnosed Cause of Heart Failure With Preserved Ejection Fraction.

Cardiac amyloidosis is an infiltrative disease characterized by the extracellular deposition of misfolded protein in the myocardium, leading to increased stiffness and an eventual restrictive cardiomyopathy. The slow onset of symptoms and overlap with other cardiomyopathies make prompt diagnosis a challenge. Clinicians should be alerted and include amyloidosis in their differential diagnosis, particularly in patients with heart failure with preserved ejection fraction, unexplained left ventricle hypertrophy, particularly in those shown intolerance to previous antihypertensive medication, and early orthopedic manifestations of the disease such as carpal tunnel syndrome and spinal stenosis.

Human dermal tissue allograft use in treating chronic pilonidal sinus.

A study was conducted to try to improve upon existing conservative techniques in the treatment of chronic pilonidal sinus by using human dermal tissue allograft. A prospective study of 46 consecutive patients undergoing 47 operations for pilonidal disease was conducted by three surgeons. All patients underwent a conservative surgical technique with injection of human dermal tissue allograft and primary wound closure on an ambulatory basis.