Recurrent high grade serous endometrial cancer with brain metastases: Immunotherapy confers improved quality of life and survival.

• Brain metastases in recurrent endometrial cancer are rare and often confer a poor prognosis. • Brian metastases can be treated with a combination of immunotherapy and radiation. • Immunotherapy can prolong survival in these patients.

Use of lung treatment plans to evaluate DIR algorithms.

The purpose of the study is to evaluate the accuracy of two deformable image registration algorithms by examining their influence on the dose summation results obtained using 4DCT (four dimensional computed tomography) dose distributions based on '4D' planned and '4D optimal' IMRT (intensity modulated radiation therapy) plans. For ten lung cancer patients, 4D step and shoot IMRT plans were produced. The breathing cycle was divided into ten parts and for each part a set of CT images was acquired.

Treatment and Outcomes of Primary Urethra Cancer.

Background: Urethral cancer is a rare malignancy, representing <1% of all malignancies. Optimal management, due to its rarity, presents as a treatment dilemma for physicians. There is a lack of consensus regarding treatment as large randomized trials cannot be performed; thus, optimal management decisions rely on study of retrospective cases.

Persistent Disparities in Hispanics with Cervical Cancer in a Major City.

Objectives: Despite an overall improvement in cervical cancer screening, incidence, and mortality rates for minorities in the USA, regional differences in screening and stage at presentation have been observed. This study evaluated cervical cancer disparities in a predominately Hispanic population treated in a major treatment center in San Antonio, Texas.

Methods And Materials: Data on 446 patients with cervical cancer treated between 2000 and 2011 at the Cancer Therapy and Research Center in San Antonio, Texas, were reviewed.

Assessment of Lung Tumour Motion and Volume Size Dependencies Using Various Evaluation Measures.

The purpose of the study was to assess internal target volume changes through the breathing cycle and associated tumour motion for lung patients and to establish possible correlations between different parameters. Respiration-induced volume changes with breathing cycle and the associated tumour motion were analyzed for 11 patients. Selected phases were the maximum and average intensity projections and the 10 phases of equal duration and separation obtained through the respiratory cycle.

Trehalose uptake through P2X7 purinergic channels provides dehydration protection.

The tetra-anionic form of ATP (ATP4-) is known to induce monovalent and divalent ion fluxes in cells that express purinergic P2X7 receptors and with sustained application of ATP it has been shown that dyes as large as 831 Da can permeate the cell membrane. The current study explores the kinetics of loading alpha,alpha-trehalose (342 Da) into ATP stimulated J774.A1 cells, which are known to express the purinergic P2X7 receptor.