Publications by authors named "Jill Theodoss"
Design, power, and interpretation of studies in the standard murine model of ALS.
Amyotroph Lateral Scler
April 2008
Article Synopsis
- Identification of SOD1 as the mutated protein in familial amyotrophic lateral sclerosis (FALS) has led to the creation of mouse models, particularly the SOD1(G93A) mouse, that are widely used for testing ALS therapies.
- Despite over 50 studies reporting lifespan extension with various therapeutic agents in these mice, only riluzole has shown clinical effectiveness in humans.
- The researchers identified key biological variables that affect study results and found that when these were controlled, several previously reported drugs, including riluzole, failed to demonstrate any significant benefits, leading to recommendations for improved study design in future research.