A homopolymer polymorphism in the TOMM40 gene contributes to cognitive performance in aging.

Introduction: A highly polymorphic T homopolymer was recently found to be associated with late-onset Alzheimer's disease risk and age of onset.

Objective: To explore the effects of the polymorphic polyT tract (rs10524523, referred as '523') on cognitive performance in cognitively healthy elderly individuals.

Methods: One hundred eighty-one participants were recruited from local independent-living retirement communities.

A genome-wide study of common SNPs and CNVs in cognitive performance in the CANTAB.

Psychiatric disorders such as schizophrenia are commonly accompanied by cognitive impairments that are treatment resistant and crucial to functional outcome. There has been great interest in studying cognitive measures as endophenotypes for psychiatric disorders, with the hope that their genetic basis will be clearer. To investigate this, we performed a genome-wide association study involving 11 cognitive phenotypes from the Cambridge Neuropsychological Test Automated Battery.

Failure to replicate effect of Kibra on human memory in two large cohorts of European origin.

It was recently suggested that the Kibra polymorphism rs17070145 has a strong effect on multiple episodic memory tasks in humans. We attempted to replicate this using two cohorts of European genetic origin (n = 319 and n = 365). We found no association with either the original SNP or a set of tagging SNPs in the Kibra gene with multiple verbal memory tasks, including one that was an exact replication (Auditory Verbal Learning Task, AVLT).