Acute monoarthritis.

Acute monoarthritis affects a single joint and has many potential underlying causes, including crystal deposition diseases, infection, trauma, and osteoarthritis. A comprehensive health history and physical examination can help narrow the list of differential diagnoses; judicious diagnostic testing can help pinpoint the diagnosis. Clinicians also must be able to recognize which patients require emergency referral to prevent long-term adverse consequences.

Supplementation with antioxidants and folinic acid for children with Down's syndrome: randomised controlled trial.

Objectives: To assess whether supplementation with antioxidants, folinic acid, or both improves the psychomotor and language development of children with Down's syndrome.

Design: Randomised controlled trial with two by two factorial design.

Setting: Children living in the Midlands, Greater London, and the south west of England.