Publications by authors named "Jill Levin Langhoff"
Article Synopsis
- Viruses are linked to over 15% of human cancer cases, but most studies have mainly looked at cancer transcriptome data rather than the viruses themselves.
- This research analyzed 197 cancer samples using high-throughput sequencing enriched for various viral groups, resulting in 710 datasets with a massive 57 billion sequencing reads.
- The study found a variety of viruses, particularly papillomaviruses and herpesviruses, in over half the samples but did not establish a specific connection between any viruses and particular cancer types.
Although nearly one fifth of all human cancers have an infectious aetiology, the causes for the majority of cancers remain unexplained. Despite the enormous data output from high-throughput shotgun sequencing, viral DNA in a clinical sample typically constitutes a proportion of host DNA that is too small to be detected. Sequence variation among virus genomes complicates application of sequence-specific, and highly sensitive, PCR methods.
View Article and Find Full Text PDFA 25-year-old female nurse was referred to our diabetes outpatient clinic with poorly controlled type 2 diabetes, obesity and elevated liver function tests (LFTs). Following a liver biopsy she was diagnosed with non-alcoholic steatohepatitis (NASH) and liver fibrosis. Treatment with subcutaneous injections of the glucagon-like peptide-1 receptor (GLP-1R) agonist liraglutide was initiated.
View Article and Find Full Text PDFEpithelioid trophoblastic tumour is a rare gestational trophoblastic disease. The diagnosis is based on microscopic morphology and immunohistochemical staining. It is important to avoid misdiagnosis, as this tumour is primarily treated by surgery rather than chemotherapy.
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