Publications by authors named "Jill E Polzin"
Clin Pharmacol Ther
June 2004
Article Synopsis
- CYP3A5 genetic polymorphisms were studied to assess their impact on drug levels of ABT-773, a ketolide antibiotic, which is metabolized by both CYP3A5 and P-glycoprotein.
- Healthy volunteers with different CYP3A5 genotypes received various doses of ABT-773, and their drug levels were measured to explore the correlation with their genetic makeup.
- Results indicated that CYP3A5-negative individuals had significantly higher drug levels (AUC and Cmax) than CYP3A5-positive individuals, suggesting that genetic variants in CYP3A5 can influence the pharmacokinetics of ABT-773.
