The influence of calibration on bias in quality control and patient results for TSH on Vitros XT 7600 analyzer.

Introduction: Thyroid-stimulating hormone (TSH) is a glycoprotein secreted by the anterior pituitary gland and is regulated by negative feedback from the serum free thyroid hormones. In this study we aimed to quantitate the relative bias caused by calibration drifting as seen in our TSH Levey-Jennings quality control (QC) charts and assess the magnitude of bias on patients' samples.

Materials And Methods: In the period from October 2021 to August 2022 we looked at the QC results of ten 28-days' calibration time intervals and calculated relative bias compared to the mean.

Analytical characterization of the Siemens Dimension EXL high-sensitivity cardiac troponin I assay.

Background: Siemens Healthcare Diagnostics has four commercially available assays on different analytical platforms using different methodologies to generate signal. We assessed the analytical performance of the Dimension EXL hs-cTnI assay (LOCI method) across different matrices and compared it to two different acridinium ester-based hs-cTnI assays (ADVIA Centaur and Abbott ARCHITECT).

Methods: The analytical sensitivity and precision below the 99th-percentile was determined for the Dimension EXL hs-cTnI assay.