Effect of periodic vibration-isolation piles on soil vibration in deep-buried tunnels of suburban railways.

This study aims to investigate the impact of isolation piles on soil vibrations in the environment surrounding suburban railways. Initially, a comprehensive numerical model of the train was established to simulate the wheel-rail interaction forces, which were then applied to a three-dimensional coupled track-soil model. The accuracy of the model was validated through comparison with measured data.

Effects of train speed and passenger capacity on the environmental vibration of viaduct and surrounding soil of suburban railways.

Compared with the general urban rail transit, some of the current rapid urban rail transit can reach a maximum speed of 140 km/h when the train is running, which exceeds the speed level of the general urban rail transit. To consider the influence of different speeds and loads on the vibration of viaducts and the surrounding soil environment, this paper establishes a three-dimensional finite element model of rail-viaduct soil. The results show that: the frequency domain acceleration of each measurement point increases with the increase of train speed; except for the measurement point which is 20 m away from the centerline of the track, the frequency domain speed of each measurement point increases with the increase of train speed; the frequency domain speed under the low-frequency component of the viaduct measurement point increases with the increase of train loading, and the growth rate is obviously larger than that of the middle and high frequency bands, and the frequency domain speed of the measurement points in the site also increases with the increase of train loading, and the growth rate of the low-frequency band is obviously larger than that of the middle and high frequency bands.

Effects of train speed and passenger capacity on ground vibration of underground suburban railways.

This study aims to explore the optimal driving speed for ground vibration in suburban railway underground sections. We focused on the ground surface of suburban railway underground sections and developed a 3D finite element dynamic coupling model for the tunnel-soil system. Subsequently, considering factors such as train speed and passenger load, we analyzed the propagation characteristics of ground vibration responses in urban railway underground sections.

Improving mass spectrometry analysis of protein structures with arginine-selective chemical cross-linkers.

Chemical cross-linking of proteins coupled with mass spectrometry analysis (CXMS) is widely used to study protein-protein interactions (PPI), protein structures, and even protein dynamics. However, structural information provided by CXMS is still limited, partly because most CXMS experiments use lysine-lysine (K-K) cross-linkers. Although superb in selectivity and reactivity, they are ineffective for lysine deficient regions.

A high-speed search engine pLink 2 with systematic evaluation for proteome-scale identification of cross-linked peptides.

We describe pLink 2, a search engine with higher speed and reliability for proteome-scale identification of cross-linked peptides. With a two-stage open search strategy facilitated by fragment indexing, pLink 2 is ~40 times faster than pLink 1 and 3~10 times faster than Kojak. Furthermore, using simulated datasets, synthetic datasets, N metabolically labeled datasets, and entrapment databases, four analysis methods were designed to evaluate the credibility of ten state-of-the-art search engines.