Publications by authors named "Jili Lu"
Association of survivin positive circulating tumor cell levels with immune escape and prognosis of osteosarcoma.
J Cancer Res Clin Oncol
November 2023
Purpose: Function of survivin protein (encoded by BIRC5) in circulating tumor cells (CTCs) of osteosarcoma (OS) has not been investigated. The goal of this study is to determine whether the expression of survivin protein of CTCs is associated with circulating immune cell infiltration and disease prognosis of OS.
Methods: Blood samples of 20 patients with OS were collected.
Osteosarcoma (OS) is a primary bone tumor with high malignancy and the mechanism of hematogenous metastasis in OS is still not clear. The plasma exosomes derived from osteosarcoma play a key role in the process of tumor metastasis. Here, we established RNA-seq dataset for lncRNAs, circRNAs and mRNAs in plasma exosomes from 10 OS patients and 5 healthy donors.
View Article and Find Full Text PDFBackground: Guanine nucleotide binding (G) protein subunit γ 4 (GNG4) is closely related to the malignant progression and poor prognosis of various tumours. However, its role and mechanism in osteosarcoma remain unclear. This study aimed to elucidate the biological role and prognostic value of GNG4 in osteosarcoma.
View Article and Find Full Text PDFBackground: This study sought to identify potential key genes for osteosarcoma metastasis and analyze their immune infiltration patterns using bioinformatic methods.
Methods: We obtained transcriptomic data related to osteosarcoma and osteosarcoma with metastasis from the Therapeutically Applicable Research to Generate Effective Treatment (TARGET) and The Gene Expression Omnibus (GEO) databases and identified the differentially expressed genes (DEGs). We also identified potential key genes for osteosarcoma metastasis by a protein-protein interaction network analysis, and we conducted a Gene Ontology (GO) functional annotation analysis and Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment analysis to identify the core genes for prognosis, immune cell infiltration, and drug sensitivity, and the risk prediction and prognosis models of metastasis were constructed.
Background: Management of recalcitrant diabetic foot ulcer (DFU) remains difficult. Distraction osteogenesis mediates new bone formation and angiogenesis in the bone itself and the surrounding tissues. Recently it was reported that tibial cortex transverse transport (TTT) was associated with neovascularization and increased perfusion at the foot in patients with recalcitrant DFUs and facilitated healing and limb salvage.
View Article and Find Full Text PDFArticle Synopsis
- Osteoarthritis (OA) is a prevalent condition in older adults, but the molecular mechanisms behind its development and progression are still unclear; this study explored these mechanisms using a competing endogenous RNA (ceRNA) network approach.
- Researchers analyzed various mRNA, miRNA, and lncRNA datasets to identify differentially expressed genes (DEGs) and constructed a ceRNA network to explore their biological functions through enrichment analyses, as well as assessing immune cell presence in OA versus healthy samples.
- Key findings revealed significant players like hsa-mir-425-3p and dual specificity phosphatase 1 in the ceRNA network, highlighting their roles in important biological processes linked to immune responses and OA progression, suggesting potential targets for further
Background: At present, no predictive factor has been validated for the early efficacy of neoadjuvant chemotherapy (NACT) in osteosarcoma. The purpose of this study was to investigate the significance of the neutrophil-to-lymphocyte ratio (NLR) in predicting the response to NACT in extremity osteosarcoma.
Methods: Pathological complete response (pCR) was used to assess the efficacy of NACT.