Effect of polycaprolactone nanofibers loaded with oxytetracycline hydrochloride and zinc oxide as an adjunct to SRP on GCF lipocalin-2 levels in periodontitis patients: A clinical and laboratory study.

The aim of this study was the clinical and laboratory evaluation of using polycaprolactone (PCL) nanofibers loaded with oxytetracycline hydrochloride (OTC) and zinc oxide (ZnO) as an adjunct to mechanical therapy in managing stage II grade A periodontitis patients concerning GCF lipocalin2- levels. Fifty stage II grade A periodontitis patients (27 women and 23 men, with an age range of 30‒60) were enrolled in the study. The patients were randomly assigned to five equal groups and treated with scaling and root planing (SRP), followed by local application of PCL nanofibers: group I: SRP + PCL loaded with OTC and ZnO, group II: SRP + PCL loaded with OTC, group III: SRP + PCL loaded with ZnO, group IV: SRP + unloaded PCL, and group V: SRP alone.

Is netrin-1 a reliable inflammatory marker for periodontitis?

Background: The current study tested netrin-1 as a reliable inflammatory marker of periodontal disease.

Methods: Gingival crevicular fluid (GCF) samples were taken at baseline from 30 systemically healthy individuals. Fifteen subjects had stage II grade A or B periodontitis, and 15 were periodontally and clinically healthy.

Localization and characterization of human papillomavirus-16 in oral squamous cell carcinoma.

Objectives: The role of Human papillomavirus (HPV) in the oral squamous cell carcinoma (OSCC) has not been completely elucidated. The purpose of the present study was to investigate the prevalence and localization of HPV-16 virus in OSCC and to correlate HPV-16 positivity and p16INK4A expression with the clinical and pathological features of OSCC.

Methods: The archives of Oral Pathology at the University of Florida, College of Dentistry were accessed for demographic, clinical, histopathological data, and slides of 114 OSCC patients.

Biological effect of the nanocrystalline calcium sulfate bone graft in the periodontal regeneration.

Background: The ultimate goal of tissue engineering is to reproduce functional alveolar∖Periodontal complex. This study aimed to asses micro- and nano-formulated crystalline calcium sulfate as possible treatment of intrabony defect utilizing an autologous Platelet rich fibrin scaffold.

Subjects: and Methods: An experimental prospective split mouth design using eight healthy mongrel dog's was conducted.

Can mandibular lingual canals be used as a forensic fingerprint?

Objectives: This study aimed to identify whether the lingual canals of the mandible can be used as a unique fingerprint when dealing with forensic victim identification.

Materials And Methods: The study consisted of two parts; an observational part and an objective image analysis part. In the observational part a total of 100 in vivo high resolution CBCT datasets of human mandibles were included in the process of simulated matching of ante-mortem (AM) and post-mortem (PM) data.

Allopurinol as a potential therapeutic agent for recurrent herpes labialis.

Recurrent herpes labialis (RHL) occurs in up to 40% of the population. Although the disease is usually self-limiting, patients seek treatment because of the significant pain and visibility of the lesion. Xanthine oxidase inhibitors (XOI) have been reported to have a potent antiviral effect against influenza-A virus.