Publications by authors named "Jikang Fan"

Background: This study investigates the role of S100A11 as a potential biomarker for glioma-associated macrophages (GAMs) and its correlation with GAMs infiltration in glioblastoma multiforme, aiming to better understand the immune microenvironment of glioma.

Methods: We conducted a comprehensive study using various techniques and approaches. First, we examined the expression of S100A11 on GAMs through Western blot, immunohistochemistry, and immunofluorescence analyses.

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Glioma, especially glioblastoma patients, present highly heterogeneous and immunosuppressive microenvironment, leading to their poor response to treatment and survival. Targeting the tumor microenvironment is considered a promising therapeutic strategy. M2 macrophages are highly infiltrated in glioma tissue, even up to 50% of the total number of bulk tissue cells.

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The titanium alloy components utilized in the aviation field are typically large in size and possess complex structures. By utilizing multiple additive manufacturing processes, the precision and efficiency requirements of production can be met. We investigated the hybrid additive manufacturing of Ti-6Al-4V using a combination of cold metal transfer additive manufacturing (CMTAM) and laser metal deposition (LMD), as well as the feasibility of using the CMT-LMD hybrid additive manufacturing process for fabricating Ti-6Al-4V components.

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Non-SMC (Structural Maintenance of Chromosomes) condensin I complex subunit H (NCAPH) has been shown to facilitate progression and predict adverse prognostic outcome in many cancer types. However, the function of NCAPH in gliomas is still unclear. Series of experiments were taken to uncover the function of NCAPH in glioma.

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Glioma is an intracranial tumor characterized by high mortality and recurrence rates. In the present study, the association of TRPM8 channel-associated factor 2 (TCAF2) in glioma was investigated using bioinformatics, showing significant relationships with age, WHO grade, IDH, and 1p/19q status, as well as being an independent predictor of prognosis. Immunohistochemistry of a glioma sample microarray showed markedly increased TCAF2 expression in glioblastoma relative to lower-grade glioma, with elevated expression predominating in the tumor center.

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Article Synopsis
  • Keeping important brain fibers safe helps patients recover better after glioma surgery.
  • Two methods, DTI and ISM, were studied to see which one helped with surgery outcomes.
  • The study found that DTI led to more complete tumor removals, but both methods had similar side effects for patients after surgery.
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The tumor immunosuppressive microenvironment (IME) significantly affects tumor occurrence, progression, and prognosis, but the underlying molecular mechanisms remain to make known. We investigated the prognostic significance of PDPN and its role in IME in glioma. Weighted gene co-expression network analysis (WGCNA) found PDPN closely related to IDH wildtype status and higher immune score.

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Background: Ferroptosis is a form of programmed cell death (PCD) that has been implicated in cancer progression, although the specific mechanism is not known. Here, we used the latest DepMap release CRISPR data to identify the essential ferroptosis-related genes (FRGs) in glioma and their role in patient outcomes.

Methods: RNA-seq and clinical information on glioma cases were obtained from the Chinese Glioma Genome Atlas (CGGA) and The Cancer Genome Atlas (TCGA).

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Glioblastoma is the most common primary intracranial malignant tumor in adults and has high morbidity and high mortality. TMEM158 has been reported to promote the progression of solid tumors. However, its potential role in glioma is still unclear.

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Bulk metallic glasses (BMGs) are promising for multifunctional and structural application in different industries. However, the limited size of BMGs hinders their further application. The welding of BMGs has shown the possibility of getting rid of the casting size limitation.

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Co-existence of meningioma and breast carcinoma metastasis in the type of collision tumor is uncommon in the brain. A 65-year-old female with a history of breast carcinoma suffered from a mass in posterior fossa of brain. After a craniotomy, the pathological specimen showed a collision tumor with breast cancer metastasis and meningioma.

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