Publications by authors named "Jijia Zheng"
Epithelial-mesenchymal transition (EMT) of retinal pigment epithelial (RPE) cells plays key roles in the pathogenesis of multiple vitreoretinal diseases, leading to profound and permanent vision loss. Circular RNAs (circRNAs) are widespread and functional endogenous RNAs that could regulate gene expression in eukaryotes. The functions of circRNAs in mediating EMT has been reported in several diseases.
View Article and Find Full Text PDFRapid detection of guttae area using aniline blue staining in Fuchs endothelial corneal dystrophy mouse model.
Clin Exp Pharmacol Physiol
October 2024
Article Synopsis
- Fuchs endothelial corneal dystrophy (FECD) leads to corneal endothelial degeneration and impaired vision due to the accumulation of guttae on Descemet's membrane.
- Researchers established a FECD mouse model using UVA exposure and utilized various staining techniques, including aniline blue (AB) and Masson's trichrome, to analyze corneal structures.
- AB staining proved to be a quick and effective method for identifying guttae areas in the corneas of FECD mice, showing significant correlation with collagen I presence in the affected regions.