Publications by authors named "Jiin Kim"
Comparative crystal structure analysis of the human EP300 and CBP KIX domains.
Biochem Biophys Res Commun
December 2024
Small-cell lung cancer (SCLC) is highly lethal because the tumors grow and metastasize rapidly. Effective treatments for SCLC are lacking currently. A recent study demonstrated that the E1A binding protein P300 (EP300) KIX domain has pro-tumorigenic activity and is selectively involved in the development and growth of SCLC.
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- Extended-spectrum β-lactamase (ESBL) and AmpC β-lactamase-producing bacteria are becoming a major global health issue due to their resistance to third-generation cephalosporins, particularly in food animals.
- A study conducted in South Korea collected 409 serovar Infantis isolates from various healthy and diseased food animals, revealing that 61.9% were resistant to ceftiofur, mainly from chickens, highlighting significant multidrug resistance patterns across the isolates.
- Molecular analysis indicated that all ceftiofur-resistant strains produced specific β-lactamase enzymes, with the majority belonging to sequence type ST32, suggesting widespread dissemination of resistance genes among food animal populations.
Objectives: To identify official sources that routinely collect data on functioning in Switzerland, to provide an overview of the existing data and its comparability, and to assess the extent to which the data is suitable for developing a functioning metric and indicator.
Methods: Data sources were identified through an iterative search. Standardized rules were applied to map the functioning information assessed by the sources using a current WHO functioning and disability survey as a reference framework for the content comparison.
The purpose was to compare the clinical and radiographic outcomes between preoperative mild and severe varus deformity after total knee arthroplasty (TKA) with medial stabilizing technique (MST). We retrospectively analyzed 158 knees of 125 female patients with a 2-year follow-up who underwent mechanically aligned TKA with MST between April 2018 and February 2021. Patients were divided into two groups; the severe varus group was defined as one with preoperative hip-knee ankle (HKA) angle ≥ 15° and the mild varus group with HKA angle < 15°.
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- - The study investigated multidrug-resistant (MDR) Agona infections from food-producing animals in South Korea, specifically focusing on 209 isolates predominantly found in chickens, pigs, cattle, and ducks from 25 slaughterhouses between 2010 and 2020.
- - Findings revealed that chicken Agona isolates had a high resistance rate (69-83%) to several antibiotics and exhibited significantly greater levels of MDR compared to isolates from cattle and pigs.
- - Molecular analysis identified 23 types of Agona isolates, with two major types (P1-III-2-13 and P1-IV-2-13) being most prevalent, and a dominant sequence type (ST13) found primarily in chickens, indicating a potential public health
Purpose: Networking with other biodosimetry laboratories is necessary to assess the radiation exposure of many individuals in large-scale radiological accidents. The Korea biodosimetry network, K-BioDos, prepared harmonized scoring guidelines for dicentric chromosome assay to obtain homogeneous results within the network and investigated the efficiency of the guidelines.
Materials And Methods: Three laboratories in K-BioDos harmonized the scoring guidelines for dicentric chromosome assay.
Purpose: To develop a Korean version of simple, intuitive descriptions (SIDs) for clinical use of the generic functioning domains in the International Classification of Disease 11 revision (ICD-11) Chapter V.
Methods: The initial Korean SID version proposal for the International Classification of Functioning, Disability, and Health (ICF) Rehabilitation set was translated following the Italian version. The remaining 17 codes were developed using original ICF descriptions; WHO Disability Assessment Schedule, Model Disability Survey, Korean Classification of Functioning, Disability, and Health; and previous studies.
Accumulation of anthocyanins in the taproot of radish is an agronomic trait beneficial for human health. Several genetic loci are related to a red skin or flesh color of radish, however, the functional divergence of candidate genes between non-red and red radishes has not been investigated. Here, we report that a novel genetic locus on the R2 chromosome, where .
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- * Results showed that dogs had significantly higher resistance rates to various antimicrobials, with cefalexin (68.9%) being the most resistant, while both species showed low resistance to amikacin and imipenem.
- * A notable 42.3% of isolates exhibited multidrug resistance, higher in dogs (34.9%) than cats (20.9%), raising public health concerns about potential transmission of resistant strains to humans or other animals.
Site-specific soil ecological risk assessment is important for protecting soil ecosystems because it reflects the environmental factors at the site to detect ecological risks and develop risk management measures. This study assessed the ecological risks from chemical pollutants in abandoned mine sites using the TRIAD approach, evaluating its overall applicability, including the tiered system of assessment. A site-specific soil ecological risk assessment was conducted for five abandoned mine sites (Sites 1-4 and R, the reference site); integrated risks (IRs) for each site were calculated.
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- - The study focused on 3D printing dental resin-based composites (DRCs) with ceramic additives using digital light processing (DLP), aiming to enhance their mechanical strength and stability.
- - It tested two ceramic additives, carbon nanotubes (CNT) and yttria-stabilized zirconia (YSZ), to improve the DRCs' properties under environmental stress commonly faced in dental applications.
- - Results showed that DRCs with 0.5 wt.% YSZ had the best hardness (19.8 HRB) and flexural strength (50.6 MPa), while maintaining good oral rinsing stability, suggesting potential for improved dental materials.
Bromodomain and extra-terminal domain (BET) proteins have been considered as potent candidates for anti-cancer drug development. As epigenetic readers, they modulate gene expression by recognizing acetylated lysine residues on histones. Therefore, the pharmacological inhibition of BET proteins has been extensively studied.
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- - The study aimed to explore how sociodemographic factors and health conditions affect the involvement of individuals with spinal cord injuries (SCI) in various activities and their overall participation in society, using data from the International Spinal Cord Injury (InSCI) Survey.
- - A total of 890 community-dwelling adults with SCI were analyzed, examining factors such as age, education, health conditions (like bowel dysfunction and pain), and involvement in activities and social interactions.
- - Results showed that health conditions significantly impact activity (51% of variance), and in turn, activities significantly influence participation (63.4% of variance), with environmental restrictions also playing a role in these relationships.
Article Synopsis
- The study investigates preventive health behaviors regarding the coronavirus pandemic among Korean young adults, focusing on the effects of risk perception variables like optimistic bias, hypochondriasis, and mass psychology.
- Results indicate that mass psychology positively influences preventive health behavior, with individuals exhibiting higher compliance in practices like mask-wearing and vaccination compared to those with lower mass psychology levels.
- The study highlights the importance of Korean collectivism and global fear of COVID-19 in shaping health behaviors, suggesting that mass psychology should guide future public health communication strategies.
Ecological risk assessment based on scientific data is crucial for understanding causal relationships between chemical pollution and environmental risks. Simultaneously, a balance is required between socioeconomic factors and scientific evidence. The TRIAD approach, which incorporates three lines of evidence (LoE)-chemical (Chem-LoE), ecotoxicological (Ecotox-LoE), and ecological (Eco-LoE)-was applied in five sites of an abandoned mine for site-specific soil ecological risk assessment (SERA).
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- * High concentrations of DDT were found in orchards, with some samples exceeding Canadian soil quality guidelines, indicating ongoing pesticide use and potential risks to soil health.
- * The research highlights the historical use of certain pesticides, using isomer ratios to differentiate between past and present pesticide application, which can inform future soil management policies in agricultural areas.
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- Traffic-related facilities generally emit less metal pollution than other sources, but their widespread presence can still contribute significantly to soil contamination.
- A study measured metal contamination in soils, revealing that concentrations of zinc (Zn), lead (Pb), and copper (Cu) were often higher than natural levels, with Zn being the most prevalent contaminant.
- The analysis identified two main sources of contamination: vehicle maintenance and emissions, categorizing pollution into different groups based on their origin, such as areas around garages and parking lots.
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- Research on targeting glucose metabolism in cancer has faced challenges due to ineffective anti-glycolytic agents and limited understanding of different cancer types' glucose use.
- A new compound, KL-11743, effectively inhibits class I glucose transporters, leading to decreased NADH levels and increased aspartate, indicating a shift to mitochondrial oxidative phosphorylation.
- The study found that mutations in key metabolic pathways make certain tumors, particularly SDHA-deficient cancers, more susceptible to GLUT inhibitors like KL-11743, showing potential for targeted cancer therapies.
Article Synopsis
- * Soil PFAS concentrations varied from 0.175 to 11.7 ng/g dry weight, with industrial complexes and landfills showing significantly higher median levels compared to other areas.
- * The predominant PFAS in the soils included PFOS, PFOA, and specific long-chain perfluorinated carboxylic acids, with notable concentrations in industrial areas, especially from textile and metal industries.
Cognitive impairment is common in bipolar disorder and is emerging as a therapeutic target to enhance quality of life and function. A systematic search was conducted on PubMed, PsycInfo, Cochrane, clinicaltrials.gov, and Embase databases for blinded or open-label randomized controlled trials evaluating the pro-cognitive effects of pharmacological, neurostimulation, or psychological interventions for bipolar disorder.
View Article and Find Full Text PDFBackground: The aim of this study was to determine the validity of using social media for depression screening.
Method: Article searches on PubMed and PsycINFO from database inception to August 20, 2019 were completed with a search string and filters.
Results: 15 articles made the inclusion criteria.
Article Synopsis
- - The study focuses on improving the classification accuracy of neuroimaging techniques in differentiating between Alzheimer's disease (AD), mild cognitive impairment (MCI) subtypes, and healthy controls (HC), using various neuroimaging modalities combined with genetic data.
- - Researchers utilized whole-brain parcelation analysis and voxel-wise analysis to extract features from neuroimaging data of 129 subjects, including AD, stable MCI, converting MCI, and healthy controls, all sourced from the Alzheimer's Disease Neuroimaging Initiative (ADNI).
- - The study aims to enhance analysis consistency and accuracy by exploring both graphical and region-based analyses across multiple binary classification groups, ultimately seeking better understanding and discrimination of neurodegenerative stages.
Article Synopsis
- Aerobic glycolysis, discovered by Warburg as a key feature of cancer, is also involved in the activation and growth of immune cells.* -
- Glucose transporters (GLUTs) enable the transport of glucose across cell membranes and are potential targets for regulating aerobic glycolysis.* -
- The study focuses on developing and improving a new set of effective oral inhibitors that target GLUT1 and GLUT3, which could lead to new treatments for cancer and autoimmune diseases.*
Article Synopsis
- The authors identified a language error in their previously published article.
- They made a correction to the text to address this issue.
- Additionally, they replaced Figure 1 to enhance clarity or accuracy.
Article Synopsis
- This study examined how thermotherapy affects gas pain, resilience after surgery, and body temperature discomfort in patients who had laparoscopic myomectomies.
- The experimental group received thermotherapy four hours post-surgery, while the control group did not, with data analyzed using various statistical methods.
- Results indicated that thermotherapy significantly reduced shoulder-related gas pain and body temperature discomfort, suggesting it could enhance post-operative recovery for patients undergoing laparoscopic surgeries.