Publications by authors named "Jiin Eom"

Article Synopsis
  • Fibroblasts (hDFs) are important for skin healing but lose effectiveness due to cell aging, which has rarely been studied.
  • Researchers are exploring the use of stem cell-derived nanovesicles (R-NVs) to enhance the functionality of aged fibroblasts while minimizing risks and improving yield.
  • The study found that R-NVs made from red light-irradiated human adipose-derived stem cells rejuvenated old fibroblasts, enhancing their healing abilities and outperforming younger fibroblasts in skin wound healing.
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Cell sheets and spheroids are cell aggregates with excellent tissue-healing effects. However, their therapeutic outcomes are limited by low cell-loading efficacy and low extracellular matrix (ECM). Preconditioning cells with light illumination has been widely accepted to enhance reactive oxygen species (ROS)-mediated ECM expression and angiogenic factor secretion.

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Various synthetic polymers based on poly(amino ester) (PAE) are suggested as candidates for gene and drug delivery owing to their pH-responsiveness, which contributes to efficient delivery performance. PAE-based pH-responsive polymers are more biodegradable and hydrophilic than other types of pH-responsive polymers. The functionality of PAE-based polymers can be reinforced by using different chemical modifications to improve the efficiency of gene and drug delivery.

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