Comparison of the mechanism of antimicrobial action of the gold(I) compound auranofin in Gram-positive and Gram-negative bacteria.

While highly effective at killing Gram-positive bacteria, auranofin lacks significant activity against Gram-negative species for reasons that largely remain unclear. Here, we aimed to elucidate the molecular mechanisms underlying the low susceptibility of the Gram-negative model organism to auranofin when compared to the Gram-positive model organism . The proteome response of exposed to auranofin suggests a combination of inactivation of thiol-containing enzymes and the induction of systemic oxidative stress.

Association of functional sequence variants of the gene with muscle collagen content in pigs.

This study examined the association between functional sequence variants (FSVs) of () genotypes and collagen content in a Landrace and Jeju native pig (JNP) crossbred population. Four muscles (, , , and ) were used for the analysis of meat collagen content, and the same animals were genotyped for the FSVs of the gene by using PCR-RFLP (polymerase chain reaction-restriction fragment length polymorphism). Three FSVs of genotypes were identified and had genotype frequencies of 0.

Impact of ventilation methods on indoor particle concentrations in a daycare center.

The objective of this study was to quantify the influence of ventilation methods on children's exposure to indoor particles in a daycare center located in an urban area. The ventilation methods applied to the center were monitored for 1 year. It appears that indoor PM and PM concentrations of the center were basically determined by outdoor conditions.

Effect of Titanium Implants Coated with Radiation-Crosslinked Collagen on Stability and Osseointegration in Rat Tibia.

This study aimed to evaluate the titanium (Ti) implants coated with collagen type Ⅰ crosslinked using gamma-irrigation or glutaraldehyde (GA). The in vitro surface observations, quantification assay, and cell studies using human mesenchymal stem cells (hMSCs) were conducted. For in vivo experiments, the implants were divided into three groups and inserted into the rat tibias: control group (non-treated Ti implant), GA group (Ti implants coated with GA-crosslinked collagen) and 25 kGy group (Ti implants coated with gamma-radiation-crosslinked collagen at dose of 25 kGy).

Anti- activity and inhibition of gastritis by extract.

is widely consumed plant as a vegetable and herbal medicine in southeastern Asia. has been reported antioxidant, improvement of bone health and antidiabetic effects. In the present study, we investigated the potential inhibitory effect of extract (AHE) on .

Surface-enhanced Raman scattering-based detection of molecules in an aqueous solution via lipid-modified gold nanorods.

Transport of molecules and ions across cellular membranes is a fundamental process in biology. Visualization of such transport is an essential element toward a better understanding of how incoming molecules or ions interact with cellular membranes and diffuse into cytoplasm. However, detection techniques for this purpose have not been explored yet.

Enhanced conversion of sucrose to isomaltulose by a mutant of Erwinia rhapontici.

Mutagenesis of Erwinia rhapontici was performed to enhance the production of isomaltulose from sucrose. A mutant strain, BN 68089, was obtained through a screening process involving automated and miniaturized cultivation in Bioscreen C. This high-throughput, miniaturized screening system was optimized to identify the mutant strain, which had a conversion yield (90%) and productivity (194 g l(-1) h(-1)).